1. The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats

Mozhgan Ghobadi Pour , Naser Mirazi* , Hojatollah Alaei, Maryam Radahmadi, Ziba Rajaei, Alireza Monsef Esfahani

Bioimpacts. 2020;10(3): 177-186. doi: 10.34172/bi.2020.22

PMCID: PMC7416014 PMID: 32793440 Scopus ID: 85089309823

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The rat cirrhotic model is made by using thioacetamide hepatotoxin for 18 weeks. The cirrhotic rats treated to some degrees by using lactulose and silymarin known standard drugs for 8 weeks.

Original Research

2. CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

Mohammad Azadbakht , Ali Sayadmanesh, Naghme Nazer, Amirhossein Ahmadi, Sara Hemmati, Hoda Mohammadzade, Marzieh Ebrahimi, Hossein Baharvand, Babak Khalaj, Mahmoud Reza Aghamaali* , Mohsen Basiri*

BioImpacts. 2022;12(4): 337-347. doi: 10.34172/bi.2021.23522

PMCID: PMC9376159 PMID: 35975204 Scopus ID: 85137404752

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PRDM1/BLIMP1 expression is increased during differentiation from naïve to effector T cell.CRISPRi-mediated suppression of this transcription factor in ex vivo-expanded primary human T cellsresulted in increased central memory phenotype in human T cells.

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