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BioImpacts. 2021;11(3): 181-185.
doi: 10.34172/bi.2021.26
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Original Research

New description of vagal nerve commanted intrapancreatic taste buds and blood glucose level: An experimental analysis

Mehmet Dumlu Aydin 1* ORCID logo, Aybike Aydin 2, Ozgur Caglar 3 ORCID logo, Muhammed Enes Aydin 4 ORCID logo, Erdem Karadeniz 5 ORCID logo, Kemal Alp Nalci 6, Rabia Demirtas 7

1 Department of Neurosurgery, Medical Faculty of Ataturk University, Erzurum, Turkey
2 Medical Faculty of Cerrapasa, Istanbul University, Istanbul, Turkey
3 Department of Pediatric Surgery, Medical Faculty of Ataturk University, Erzurum, Turkey
4 Department of Anesthesiology and Reanimation, Medical Faculty of Ataturk University, Erzurum, Turkey
5 Department of General Surgery, Medical Faculty of Ataturk University, Erzurum, Turkey
6 Department of Pharmacology, Medical Faculty of Ataturk University, Erzurum, Turkey
7 Department of Pathology, Medical Faculty of Ataturk University, Erzurum, Turkey
Corresponding author: Mehmet Dumlu Aydin, Email: nmda11@hotmail.com nmda11@hotmail.com

Abstract

Introduction: There have been thousands of neurochemical mechanism about blood glucose level regulation, but intrapancreatic taste buds and their roles in blood glucose level has not been described. We aimed to investigate if there are taste buds cored neural networks in the pancreas, and there is any relationship between blood glucose levels.
Methods: This examination was done on 32 chosen rats with their glucose levels. Animals are divided into owned blood glucose levels. If mean glucose levels were equal to 105 ± 10 mg/dL accepted as euglycemic (G-I; n = 14), 142 ± 18 mg/dL values accepted as hyperglycemic (G-II; n = 9) and 89 ± 9 mg/dL accepted as hypoglycemic (G-III; n = 9). After the experiment, animals were sacrificed under general anesthesia. Their pancreatic tissues were examined histological methods and numbers of newly described taste bud networks analyzed by Stereological methods. Results compared with Mann-Whitney U test P < 0.005 considered as significant. Results: The mean normal blood glucose level (mg/dL) and taste bud network densities of per cm3 were: 105 ± 10 mg/dL; 156±21 in G-I; 142 ± 18 mg/dL and 95 ± 14 in G-II and 89 ± 9 mg/dL and 232 ± 34 in G-III. P values as follows: P < 0.001 of G-II/G-I; P < 0.005 of G-III/G-I and P < 0.0001 of G-III/G-II. We detected periarterial located taste buds like cell clusters and peripherally located ganglia connected with Langerhans cells via thin nerve fibers. There was an inverse relationship between the number of taste buds networks and blood glucose level.
Conclusion: Newly described intrapancreatic taste buds may have an important role in the regulation of blood glucose level.
Keywords: Taste buds, Pancreas, Blood glucose level
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Submitted: 07 Apr 2020
Revision: 19 Jun 2020
Accepted: 04 Jul 2020
ePublished: 28 Jul 2020
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