Logo-bi
Bioimpacts. 2020;10(4): 209-215.
doi: 10.34172/bi.2020.27

PMCID: PMC7502909
  Abstract View: 227
  PDF Download: 81
  Full Text View: 9

Original Research

Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial

Khalil Ansarin 1,2 ORCID logo, Ramin Tolouian 3, Mohammadreza Ardalan 4* ORCID logo, Ali Taghizadieh 2,5, Mojtaba Varshochi 6, Soheil Teimouri 5, Tahere Vaezi 5, Hamed Valizadeh 2,5, Parviz Saleh 4, Saeid Safiri 7,8 ORCID logo, Kenneth R. Chapman 9 ORCID logo

1 Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Division of Nephrology, University of Arizona, Tucson, AZ, USA
4 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7 Department of Community Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
8 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
9 Asthma and Airway Center, University Health Network, University of Toronto, Toronto, ON, Canada
*Corresponding author: Mohammadreza Ardalan, Email: ardalan34@yahoo.com; ardalan34@yahoo.com

Abstract

Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19.
Methods: An open-label randomized clinical trial study was performed in Tabriz, North-West of Iran. They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. The primary outcome was a decrease in the rate of ICU admissions, intubation/mechanical ventilation, and mortality.
Results: A total of 78 patients with similar demographic and disease characteristics were enrolled. There was a significant reduction in ICU admissions (2 out of 39 vs. 11 out of 39, P = 0.006), intubation (1 out of 39 vs. 9 out of 39, P = 0.007) and death (0 vs. 5, P = 0.027) in the bromhexine treated group compared to the standard group. No patients were withdrawn from the study because of adverse effects.
Conclusion: The early administration of oral bromhexine reduces the ICU transfer, intubation, and the mortality rate in patients with COVID-19. This affordable medication can easily be administered everywhere with a huge positive impact(s) on public health and the world economy. Altogether, the verification of our results on a larger scale and different medical centers is strongly recommended.
Trial Registration: IRCT202003117046797N4; https://irct.ir/trial/46969.

Keywords: Bromhexine hydrochloride, COVID-19 disease, SARS-CoV2, TMPRSS2, COVID-19 pneumonia, COVID-19 treatment
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 227

Your browser does not support the canvas element.


PDF Download: 81

Your browser does not support the canvas element.


Full Text View: 9

Your browser does not support the canvas element.

Submitted: 07 Jul 2020
Revision: 16 Jul 2020
Accepted: 18 Jul 2020
ePublished: 19 Jul 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)