Roghaiyeh Ilghami ORCID, Hafez Mohammadhasanzadeh ORCID, Jaleh Barar ORCID, Mohammad A. Rafi* ORCID
Bioimpacts. 2020;10(4): 207-208. doi: 10.34172/bi.2020.26
PMCID: PMC7502912     PMID: 32983935     Scopus ID: 85092069314    
Mohammad Rafi received his PhD in Animal Biology from the University of Montpellier, France, in 1970. Though he has worked on several lysosomal storage diseases, his main research interest is gene therapy of neurodegenerative disorders using animal models of globoid cell leukodystrophy (Krabbe disease). With successful AAVrh10-mediated treatment of murine and canine models, his research is moving towards the treatment trials of human patients.
Original Research COVID-19
Khalil Ansarin ORCID, Ramin Tolouian, Mohammadreza Ardalan* ORCID, Ali Taghizadieh, Mojtaba Varshochi, Soheil Teimouri, Tahere Vaezi, Hamed Valizadeh, Parviz Saleh, Saeid Safiri ORCID, Kenneth R. Chapman ORCID
Bioimpacts. 2020;10(4): 209-215. doi: 10.34172/bi.2020.27
PMCID: PMC7502909     PMID: 32983936     Scopus ID: 85092050012    
Based on a randomized clinical trial, bromhexine is proposed as a potential therapeutic option in COVID-19. A total of 78 patients with similar demographic and disease characteristics were treated with results showing a significant reduction in ICU admissions.
Original Research
Maryam Asariha ORCID, Azam Chahrdoli, Farshad Qalekhani, Mahnaz Ghowsi, Mehdi Fouladi, Maryam Gholamhosseinpour, Ali Fattahi* ORCID
Bioimpacts. 2020;10(4): 217-226. doi: 10.34172/bi.2020.28
PMCID: PMC7502908     PMID: 32983937     Scopus ID: 85092035841    
In this study biocompatible gold nanoparticles (GNPs) were synthesized using chondroitin sulfate (CHS) as reducing and capping materials. CHS-GNPs were characterized (UV, XRD-FTIR and TEM) and their biological (antibacterial, antioxidant and cytotoxicity effects and blood compatibility) and electrochemical properties were evaluated.
Original Research
Babatomiwa Kikiowo* ORCID, Adewale Joseph Ogunleye, Olumide Kayode Inyang, Niyi Samuel Adelakun, Olaposi Idowu Omotuyi, Damilohun Samuel Metibemu, Temitope Israel David, Oluwatoyin Olajide Oludoyi, Taiwo Tolulope Ijatuyi
Bioimpacts. 2020;10(4): 227-234. doi: 10.34172/bi.2020.29
PMCID: PMC7502905     PMID: 32983938     Scopus ID: 85092042568    
Flavones scaffold interacts with the molybdenum atomic domain and some other amino acid residues of XO that are essential for enzymatic action and hence blocked catalytic activities.
Original Research
Mitra Moeinzadeh ORCID, Babak Kheirkhah* ORCID, Kumarss Amini ORCID, Ali Pouryasin ORCID
Bioimpacts. 2020;10(4): 235-242. doi: 10.34172/bi.2020.30
PMCID: PMC7502904     PMID: 32983939     Scopus ID: 85092032467    
High prevalence of HPV- 53 and HPV-16 detected among participants with normal cytology can be considered as a tip-off development of cervical cancer among Iranian women.
Original Research
Sevda Rahimzadeh ORCID, Reza Rahbarghazi, Somayeh Aslani, Hadi Rajabi, Zeinab Latifi, Majid Farshdousti Hagh, Alireza Nourazarian, Hojjatollah Nozad Charoudeh, Mohammad Nouri* ORCID, Alireza Abhari* ORCID
Bioimpacts. 2020;10(4): 243-250. doi: 10.34172/bi.2020.31
PMCID: PMC7502906     PMID: 32983940     Scopus ID: 85092056978    
Adipose-derived mesenchymal stem cells were incubated with osteogenic differentiation medium. RNA and DNA were extracted on days 0, 7, 14 and 21 days of differentiation period. The expression and promoter methylation of DLX3, ATF4, and FRA1 genes were analyzed by real-time polymerase chain reaction and methylation-specific quantitative PCR, respectively
Original Research
Majid Gholipour* ORCID, Arezoo Tabrizi ORCID
Bioimpacts. 2020;10(4): 251-257. doi: 10.34172/bi.2020.32
PMCID: PMC7502907     PMID: 32983941     Scopus ID: 85092016587    
Increased MAP4K1 expression did not influence Lats1 activation. The exercise training protocol suppressed Mst1 and Lats1 (Hippo pathway) and caused an increase in Yap1 expression level, which led to physiological cardiac hypertrophy in healthy rats.
Original Research
Jaber Dehghani ORCID, Khosro Adibkia* ORCID, Ali Movafeghi, Mohammad M. Pourseif, Yadollah Omidi* ORCID
Bioimpacts. 2020;10(4): 259-268. doi: 10.34172/bi.2020.33
PMCID: PMC7502910     PMID: 32983942     Scopus ID: 85092049453    
Microalgae can consider as a more powerful platform for the production of different types of therapeutic proteins such as hIL-2.
Original Research
Vivek Puri, Manju Nagpal* ORCID, Ameya Sharma, Gurjeet Singh Thakur, Manjinder Singh, Geeta Aggarwal
Bioimpacts. 2020;10(4): 269-278. doi: 10.34172/bi.2020.34
PMCID: PMC7502911     PMID: 32983943     Scopus ID: 85092036913    
In vivo studies indicated that the induction of systolic and diastolic blood pressure in the optimized formulation (NC1) was significantly decreased in comparison to the disease control group at all time intervals along with pure drug .