Roghaiyeh Ilghami  , Hafez Mohammadhasanzadeh , Jaleh Barar , Mohammad A. Rafi*
Mohammad Rafi received his PhD in Animal Biology from the University of Montpellier, France, in 1970. Though he has worked on several lysosomal storage diseases, his main research interest is gene therapy of neurodegenerative disorders using animal models of globoid cell leukodystrophy (Krabbe disease). With successful AAVrh10-mediated treatment of murine and canine models, his research is moving towards the treatment trials of human patients.
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Original Research
COVID-19
Khalil Ansarin , Ramin Tolouian, Mohammadreza Ardalan* , Ali Taghizadieh, Mojtaba Varshochi, Soheil Teimouri, Tahere Vaezi, Hamed Valizadeh, Parviz Saleh, Saeid Safiri , Kenneth R. Chapman
Based on a randomized clinical trial, bromhexine is proposed as a potential therapeutic option in COVID-19. A total of 78 patients with similar demographic and disease characteristics were treated with results showing a significant reduction in ICU admissions.
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Maryam Asariha , Azam Chahrdoli, Farshad Qalekhani, Mahnaz Ghowsi, Mehdi Fouladi, Maryam Gholamhosseinpour, Ali Fattahi*
In this study biocompatible gold nanoparticles (GNPs) were synthesized using chondroitin sulfate (CHS) as reducing and capping materials. CHS-GNPs were characterized (UV, XRD-FTIR and TEM) and their biological (antibacterial, antioxidant and cytotoxicity effects and blood compatibility) and electrochemical properties were evaluated.
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Babatomiwa Kikiowo* , Adewale Joseph Ogunleye, Olumide Kayode Inyang, Niyi Samuel Adelakun, Olaposi Idowu Omotuyi, Damilohun Samuel Metibemu, Temitope Israel David, Oluwatoyin Olajide Oludoyi, Taiwo Tolulope Ijatuyi
Flavones scaffold interacts with the molybdenum atomic domain and some other amino acid residues of XO that are essential for enzymatic action and hence blocked catalytic activities.
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Mitra Moeinzadeh , Babak Kheirkhah* , Kumarss Amini , Ali Pouryasin
High prevalence of HPV- 53 and HPV-16 detected among participants with normal cytology can be considered as a tip-off development of cervical cancer among Iranian women.
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Sevda Rahimzadeh , Reza Rahbarghazi, Somayeh Aslani, Hadi Rajabi, Zeinab Latifi, Majid Farshdousti Hagh, Alireza Nourazarian, Hojjatollah Nozad Charoudeh, Mohammad Nouri* , Alireza Abhari*
Adipose-derived mesenchymal stem cells were incubated with osteogenic differentiation medium. RNA and DNA were extracted on days 0, 7, 14 and 21 days of differentiation period. The expression and promoter methylation of DLX3, ATF4, and FRA1 genes were analyzed by real-time polymerase chain reaction and methylation-specific quantitative PCR, respectively
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Majid Gholipour* , Arezoo Tabrizi
Increased MAP4K1 expression did not influence Lats1 activation. The exercise training protocol suppressed Mst1 and Lats1 (Hippo pathway) and caused an increase in Yap1 expression level, which led to physiological cardiac hypertrophy in healthy rats.
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Jaber Dehghani , Khosro Adibkia* , Ali Movafeghi, Mohammad M. Pourseif, Yadollah Omidi*
Microalgae can consider as a more powerful platform for the production of different types of therapeutic proteins such as hIL-2.
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Vivek Puri, Manju Nagpal* , Ameya Sharma, Gurjeet Singh Thakur, Manjinder Singh, Geeta Aggarwal
In vivo studies indicated that the induction of systolic and diastolic blood pressure in the optimized formulation (NC1) was significantly decreased in comparison to the disease control group at all time intervals along with pure drug .
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