Zahra Oushyani Roudsari
1,2 
, Zahra Esmaeili
3, Nafiseh Nasirzadeh
3, Saeed Heidari Keshel
4,5, Farshid Sefat
6,7, Hassan Bakhtyari
8, Samad Nadri
9,10,3* 1 Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2 Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3 Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4 Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, UK
7 Research Centre in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, UK
8 Department of Pediatrics, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
9 Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
10 Zanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract
Introduction: Due to the recent advances in biomedicine and the increasing understanding of the molecular mechanism of diseases, healthcare approaches have tended towards preventive and personalized medicine. Consequently, in recent decades, the utilization of interdisciplinary technologies such as microfluidic systems had a significant increase to provide more accurate high throughput diagnostic/therapeutic methods.
Methods: In this article, we will review a summary of innovations in microfluidic technologies toward improving personalized biomolecular diagnostics, drug screening, and therapeutic strategies.
Results: Microfluidic systems by providing a controllable space for fluid flow, three-dimensional growth of cells, and miniaturization of molecular experiments are useful tools in the field of personalization of health and treatment. These conditions have enabled the potential to carry out studies like; disease modeling, drug screening, and improving the accuracy of diagnostic methods.
Conclusion: Microfluidic devices have become promising point-of-care (POC) and personalized medicine instruments due to their ability to perform diagnostic tests with small sample volumes, cost reduction, high resolution, and automation.