Logo-bi
Bioimpacts. 2015;5(3): 123-127. doi: 10.15171/bi.2015.20
PMID: 26457249        PMCID: PMC4597159

Perspective

Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders

Khalil Ansarin 1, Maryam Khoubnasabjafari 1, Abolghasem Jouyban 2 *

Cited by CrossRef: 71


1- Pal V, Roy S. Bioactive Peptide Nano-assemblies with pH-Triggered Shape Transformation for Antibacterial Therapy. ACS Appl Nano Mater. 2022;5(8):12019 [Crossref]
2- Anusaraporn S, Autarmat S, Treesubsuntorn C, Thiravetyan P. Application of Bacillus sp. N7 to enhance ozone tolerance of various Oryza sativa in vegetative phase: Possible mechanism and rice productivity. Biocatalysis and Agricultural Biotechnology. 2020;25:101591 [Crossref]
3- Reed E, Case A. Defining the nuanced nature of redox biology in post-traumatic stress disorder. Front Physiol. 2023;14 [Crossref]
4- Mamenko T, Kots S. Lipid peroxidation of cell membranes in the formation and regulation of plant protective reactions. Ukr Bot J. 2020;77(4):331 [Crossref]
5- Azizi S, Shahrisa A, Khoubnasabjafari M, Ansarin K, Khoubnasabjafari M, Soleymani J, Jouyban A. A possible reason for the low reproducibility of malondialdehyde determinations in biological samples. Bioanalysis. 2016;8(21):2179 [Crossref]
6- Guo M, Gu L, Hui H, Li X, Jin L. Extracts of Dracocephalum tanguticum Maxim Ameliorate Acute Alcoholic Liver Disease via Regulating Transcription Factors in Mice. Front Pharmacol. 2022;13 [Crossref]
7- Sprouse J, Sampath C, Gangula P. 17β-Estradiol Suppresses Gastric Inflammatory and Apoptotic Stress Responses and Restores nNOS-Mediated Gastric Emptying in Streptozotocin (STZ)-Induced Diabetic Female Mice. Antioxidants. 2023;12(3):758 [Crossref]
8- Bejaoui S, Chetoui I, Ghribi F, Soudani N, Cafsi M. Different frying processes stimulate lipid peroxidation and promote changes in the composition of cholesterol, free fatty acids and triglycerides in the commercial clam’s tissues Venerupis decussata . 2022;18(2):87 [Crossref]
9- Akmal M, Abdel Aziz I, Nur Azlina M. Piper sarmentosum Roxb. methanolic extract prevents stress-induced gastric ulcer by modulating oxidative stress and inflammation. Front Pharmacol. 2023;13 [Crossref]
10- Ilyas S, Hutahaean S, Irianti D. Transforming growth factor expression (TGF-β) correlate with serum level of malondialdehyde (MDA) after EVOO administration in preclinical rat models of preeclampsia. IOP Conf Ser: Earth Environ Sci. 2018;130:012048 [Crossref]
11- Kutbi D, Almalki R. Valsartan Mitigates the Progression of Methotrexate-Induced Acute Kidney Injury in Rats via the Attenuation of Renal Inflammation and Oxidative Stress. JIR. 2024;Volume 17:2233 [Crossref]
12- Hernandez-Castillo C, Termini J, Shuck S. DNA Adducts as Biomarkers To Predict, Prevent, and Diagnose Disease—Application of Analytical Chemistry to Clinical Investigations. Chem Res Toxicol. 2020;33(2):286 [Crossref]
13- Sharma T, Sharma K, Mishra B, Variyar P. Detection of gamma radiation processed onion during storage using propidium iodide based fluorescence microscopy. Food Chemistry. 2023;398:133928 [Crossref]
14- Chkhitauri L, Sanikidze T, Giorgadze E, Asatiani K, Kipiani N, Momtselidze N, Mantskava M. Comprehensive study of the rheological status and intensity of oxidative stress during the progression of type 2 diabetes mellitus to prevent its complications. CH. 2023;83(1):69 [Crossref]
15- El-Desoky B, El-Sayed S, El-Said E. Protective effect of green tea extract against cadmium-induced testicular damage in rats in respect of oxidant/antioxidant equilibrium and androgen production. Mans Vet Med J. 2020;21(1):31 [Crossref]
16- Zhang P, Liu X, Huang G, Bai C, Zhang Z, Li H. Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK. Biochemical and Biophysical Research Communications. 2017;490(4):1215 [Crossref]
17- Gugliandolo A, Bramanti P, Mazzon E. Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?. IJMS. 2020;21(14):4875 [Crossref]
18- Singh A, Verma A, Bhardwaj B, Saraf P, Kumar H, Jain N, Waiker D, Gajendra T, Krishnamurthy S, Shrivastava S. Structure-Guided Design, Synthesis, and Biological Evaluation of Peripheral Anionic Site Selective and Brain Permeable Novel Oxadiazole-Piperazine Conjugates against Alzheimer’s Disease with Antioxidant Potential. ACS Omega. 2024; [Crossref]
19- Le Du-Carrée J, Boukhari R, Cachot J, Cabon J, Louboutin L, Morin T, Danion M. Generational effects of a chronic exposure to a low environmentally relevant concentration of glyphosate on rainbow trout, Oncorhynchus mykiss. Science of The Total Environment. 2021;801:149462 [Crossref]
20- Alvarez-Mon M, Ortega M, García-Montero C, Fraile-Martinez O, Lahera G, Monserrat J, Gomez-Lahoz A, Molero P, Gutierrez-Rojas L, Rodriguez-Jimenez R, Quintero J, Alvarez-Mon M. Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker. J Int Med Res. 2022;50(5):030006052210949 [Crossref]
21- Mansur R, Cunha G, Asevedo E, Zugman A, Rios A, Salum G, Pan P, Gadelha A, Levandowski M, Belangero S, Manfro G, Stertz L, Kauer-Sant’anna M, Miguel E, Bressan R, Mari J, Grassi-Oliveira R, Brietzke E. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample. Eur Child Adolesc Psychiatry. 2017;26(5):521 [Crossref]
22- Li Q, Qu M, Wang N, Wang L, Fan G, Yang C. Betaine protects rats against ischemia/reperfusion injury-induced brain damage. Journal of Neurophysiology. 2022;127(2):444 [Crossref]
23- Khoubnasabjafari M, Soleymani J, Jouyban A. Avoid using spectrophotometric determination of malondialdehyde as a biomarker of oxidative stress. Biomarkers in Medicine. 2018;12(6):551 [Crossref]
24- Ricklefs-Johnson K, Johnston C, Sweazea K. Ground flaxseed increased nitric oxide levels in adults with type 2 diabetes: A randomized comparative effectiveness study of supplemental flaxseed and psyllium fiber. Obesity Medicine. 2017;5:16 [Crossref]
25- Sousa B, Pitt A, Spickett C. Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds. Free Radical Biology and Medicine. 2017;111:294 [Crossref]
26- Nunes M, Schimith L, da Costa-Silva D, Lopes A, Leandro L, Martins I, de Mello R, Hartmann D, de Carvalho N, da Rosa P, Trevisan R, Di Giulio R, Posser T, Franco J. Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish. Oxidative Medicine and Cellular Longevity. 2019;2019:1 [Crossref]
27- Aroosa S, Sattar A, Javeed A, Usman M, Hafeez M, Ahmad M, Jiang N. Protective Effects of Dexmedetomidine Infusion on Genotoxic Potential of Isoflurane in Patients Undergoing Emergency Surgery. International Journal of Clinical Practice. 2023;2023:1 [Crossref]
28- Lorençoni M, Silva R, Azevedo Júnior R, Fronza M. EFFECT OF PASTEURIZATION ON THE ANTIOXIDANT AND OXIDANT PROPERTIES OF HUMAN MILK. Rev paul pediatr. 2021;39 [Crossref]
29- Augustine J, Troendle E, Barabas P, McAleese C, Friedel T, Stitt A, Curtis T. The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy. Front Endocrinol. 2021;11 [Crossref]
30- Sun P, Chen Q, Luo S, Yu X, Zhang X, Xu N, Sun X. The role and mechanism of abscisic acid in mitigating the adverse impacts of high temperature in Gracilariopsis lemaneiformis. J Appl Phycol. 2022;34(2):1073 [Crossref]
31- Leathem A, Simone M, Dennis J, Witting P. The Cyclic Nitroxide TEMPOL Ameliorates Oxidative Stress but Not Inflammation in a Cell Model of Parkinson’s Disease. Antioxidants. 2022;11(2):257 [Crossref]
32- Khoubnasabjafari M, Ansarin K, Jouyban A. Salivary malondialdehyde as an oxidative stress biomarker in oral and systemic diseases. J Dent Res Dent Clin Dent Prospects. 2016;10(2):71 [Crossref]
33- Li Z, Ali Shah S, Zhou Q, Yin X, Teng X. The contributions of miR-25-3p, oxidative stress, and heat shock protein in a complex mechanism of autophagy caused by pollutant cadmium in common carp (Cyprinus carpio L.) hepatopancreas. Environmental Pollution. 2021;287:117554 [Crossref]
34- de Sales K, Pinto B, Ribeiro N, Melo T, Galvão-Moreira L, de Brito Filho S, Nigri F. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine. 2019;2019:1 [Crossref]
35- Jîtcă G, Fogarasi E, Ősz B, Vari C, Tero-Vescan A, Miklos A, Bătrînu M, Rusz C, Croitoru M, Dogaru M. A Simple HPLC/DAD Method Validation for the Quantification of Malondialdehyde in Rodent’s Brain. Molecules. 2021;26(16):5066 [Crossref]
36- Santoso J, Notopuro H, Qurnianingsih E. Effect of Ethanol Extract of Mangosteen Peel on Serum Malondialdehyde and Leukotriene B4 Levels in Male White Rats (Rattus norvegicus) Wistar Strain Exposed with Electric Cigarette Smoke. FMI. 2021;56(4):283 [Crossref]
37- Ghelli F, Bellisario V, Squillacioti G, Panizzolo M, Santovito A, Bono R. Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms. Toxics. 2021;9(8):178 [Crossref]
38- Mektrirat R, Rueangsri T, Keeratichandacha W, Soonsawat S, Boonyapakorn C, Pongkan W. Polyunsaturated Fatty Acid EAB-277® Supplementation Improved Heart Rate Variability and Clinical Signs in Tracheal Collapse Dogs. Front Vet Sci. 2022;9 [Crossref]
39- Jin M, Cao B, Lin C, Li J, Xu Q, Ren Q, Xu S, Tang C. Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against Preeclampsia via Regulation of Oxidative Stress and NO Signaling. Front Pharmacol. 2022;13 [Crossref]
40- Panda P, Verma H, Lakkakula S, Merchant N, Kadir F, Rahman S, Jeffree M, Lakkakula B, Rao P, Huang Y. Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2022;2022:1 [Crossref]
41- Kantaria M, Kantaria M, Machavariani P, Ormotsadze G, Ormotsadze G, Ormotsadze G, Kakabadze K, Chkhikvishvili I, Chkhikvishvili I, Buleishvili M, Buleishvili M, Buleishvili M, Kipiani N, Agladze V, Sanikidze T, Sanikidze T, Yin J. Comparative Analysis of Atherosclerosis Risk Factors in the Staff of the Tbilisi (Georgia) Cleaning Service. JAA. 2020;2(1):1 [Crossref]
42- Kucukkurt I, Ince S, Eryavuz A, Demirel H, Arslan‐Acaroz D, Zemheri‐Navruz F, Durmus I. The effects of boron‐supplemented diets on adipogenesis‐related gene expressions, anti‐inflammatory, and antioxidative response in high‐fat fed rats. J Biochem & Molecular Tox. 2023;37(2) [Crossref]
43- Zuin M, Capatti E, Borghi C, Zuliani G. Serum Malondialdehyde Levels in Hypertensive Patients: A Non-invasive Marker of Oxidative Stress. A Systematic Review and Meta-analysis. High Blood Press Cardiovasc Prev. 2022;29(3):263 [Crossref]
44- Raju R, Sahoo C, Hanjagi P, Samal K, Devanna B, Dash M, Awaji S, Baig M. Oxidative metabolism, moisture imbibing capacity and their association with pre-harvest sprouting in rice. CEREAL RESEARCH COMMUNICATIONS. 2024;52(1):115 [Crossref]
45- Vishakha K, Das S, Ganguli A. Photodynamic antibacterial and antibiofilm activity of riboflavin against Xanthomonas oryzae pv oryzae: an ecofriendly strategy to combat bacterial leaf blight (BLB) rice disease. Arch Microbiol. 2022;204(9) [Crossref]
46- Baghcheghi Y, Salmani H, Beheshti F, Shafei M, Sadeghnia H, Soukhtanloo M, Ebrahimzadeh Bideskan A, Hosseini M. Effects of PPAR-γ agonist, pioglitazone on brain tissues oxidative damage and learning and memory impairment in juvenile hypothyroid rats. International Journal of Neuroscience. 2019;129(10):1024 [Crossref]
47- Tabernilla A, dos Santos Rodrigues B, Pieters A, Caufriez A, Leroy K, Van Campenhout R, Cooreman A, Gomes A, Arnesdotter E, Gijbels E, Vinken M. In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach. IJMS. 2021;22(9):5038 [Crossref]
48- Meinke M, Nowbary C, Schanzer S, Vollert H, Lademann J, Darvin M. Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin. Nutrients. 2017;9(7):775 [Crossref]
49- Tsai I, Shen W, Wu J, Chang Y, Lin C. Autoantibodies to Oxidatively Modified Peptide: Potential Clinical Application in Coronary Artery Disease. Diagnostics. 2022;12(10):2269 [Crossref]
50- Ristic J, Folic M, Radonjic K, Rosic M, Bolevich S, Alisultanovich O, Draginic N, Andjic M, Jeremic J, Milosavljevic I, Zivkovic V, Jakovljevic V. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity. 2020;2020:1 [Crossref]
51- Zainumi C, Siregar G, Wijaya D, Ichwan M. Comparison enteral superoxide dismutase 1 IU and 5 IU from Cucumis melo L.C extract combined with gliadin as an antioxidant and anti-inflammatory in LPS-Induced sepsis model rats. Heliyon. 2022;8(8):e10236 [Crossref]
52- Khoubnasabjafari M, Jouyban A. Comments on “Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors”. Eur Arch Psychiatry Clin Neurosci. 2017;267(6):595 [Crossref]
53- Fois S, Canu S, Fois A. The Role of Oxidative Stress in Sarcoidosis. IJMS. 2021;22(21):11712 [Crossref]
54- Panelli M, Garcia J, de Souza S, Costa M, Ferron A, Gregolin C, Minatel I, Ferraz A, Pierine D, Francisqueti- Ferron F, Corrêa C. Preventive effect of the bark of Passiflora edulis on obesity-related disorders and oxidative stress in db/db mice. Nutrire. 2019;44(1) [Crossref]
55- Wee C, Mokhtar S, Singh K, Yahaya S, Leung S, Rasool A, Ghosh R. Calcitriol Supplementation Ameliorates Microvascular Endothelial Dysfunction in Vitamin D-Deficient Diabetic Rats by Upregulating the Vascular eNOS Protein Expression and Reducing Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2021;2021:1 [Crossref]
56- Ibrahim N, Naina Mohamed I. Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health. Life. 2021;11(2):103 [Crossref]
57- Smith S, Lopresti A, Fairchild T. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2023;37(11):1091 [Crossref]
58- RIASARI H, FITRIANSYAH S, FAUZI N. ANTI-DIABETIC ACTIVITY OF KABAU SEED POWDER SUSPENSION (ARCHIDENDRON BUBALINUM (JACK) I. C. NIELSEN) IN ALLOXAN-INDUCED DIABETIC RATS. Int J App Pharm. 2023;:7 [Crossref]
59- Meinke M, Schanzer S, Lohan S, Shchatsinin I, Darvin M, Vollert H, Magnussen B, Köcher W, Helfmann J, Lademann J. Comparison of different cutaneous carotenoid sensors and influence of age, skin type, and kinetic changes subsequent to intake of a vegetable extract. J Biomed Opt. 2016;21(10):107002 [Crossref]
60- Perović A, Sobočanec S, Dabelić S, Balog T, Dumić J. Effect of scuba diving on the oxidant/antioxidant status, SIRT1 and SIRT3 expression in recreational divers after a winter nondive period. Free Radical Research. 2018;52(2):188 [Crossref]
61- Hassan N, Bassossy H, Fahmy A, Mahmoud M. Limonin alleviates macro- and micro-vascular complications of metabolic syndrome in rats: A comparative study with azelnidipine. Phytomedicine. 2018;43:92 [Crossref]
62- Abunofal O, Mohan C. Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review. Medicines. 2022;9(3):20 [Crossref]
63- Jomova K, Raptova R, Alomar S, Alwasel S, Nepovimova E, Kuca K, Valko M. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol. 2023;97(10):2499 [Crossref]
64- Andre L, Jose D, Clivia R, Deisylaine M, Antonio S, Pietra A, Rafaela K, Jose E, Jose N, Carla M, Andrea Y, Brancilene S, Charles S. Myracrondruon urundeuva Allemo: Chemical composition, antioxidant activity, antimicrobial activity and inotropic effect. Afr J Biotechnol. 2017;16(21):1230 [Crossref]
65- Devrim-Lanpir A, Hill L, Knechtle B. Efficacy of Popular Diets Applied by Endurance Athletes on Sports Performance: Beneficial or Detrimental? A Narrative Review. Nutrients. 2021;13(2):491 [Crossref]
66- Kunce W, Stoks R, Johansson F. Single and mixture impacts of two pyrethroids on damselfly predatory behavior and physiological biomarkers. Aquatic Toxicology. 2017;190:70 [Crossref]
67- Zanjani B, Samadi A, Isikhan S, Lay I, Beyaz S, Gelincik A, Buyukozturk S, Arda N. Plasma levels of oxysterols 7-ketocholesterol and cholestane-3β, 5α, 6β-triol in patients with allergic asthma. Journal of Asthma. 2023;60(2):288 [Crossref]
68- Cha Y, Chang J, Kim H, Park K. Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning. Metabolites. 2022;12(3):201 [Crossref]
69- Salimi A, Shabani M, Nikjou A, Choupani M, Biniyaz M. Exploring the possible mitoprotective and neuroprotective potency of thymoquinone, betanin, and vitamin D against cytarabine‐induced mitochondrial impairment and neurotoxicity in rats' brain. J Biochem & Molecular Tox. 2023;37(2) [Crossref]
70- de Sousa Lima Neto J, Marena G, Girotto L, Magorpo V, dos Santos Ramos M, da Silva P, Chorilli M, Bauab T, Resende F. Biological Properties of Extracts from Byrsonima Species in Microemulsions. Rev Bras Farmacogn. 2022;32(3):460 [Crossref]
71- Zhang Q, Adam K. Proposal and confirmation of N‐(2‐carboxyethyl)proline as a human endogenous metabolite. Rapid Comm Mass Spectrometry. 2024;38(10) [Crossref]
72- Lee K, Jung W, Suh B, Cha S. Questionable Reliability of Malondialdehyde to Measure Oxidative Stress in Sjögren’s Syndrome: Preliminary Study. JOMP. 2020;45(4):89 [Crossref]
73- Nowak A, Relja B. The Impact of Acute or Chronic Alcohol Intake on the NF-κB Signaling Pathway in Alcohol-Related Liver Disease. IJMS. 2020;21(24):9407 [Crossref]
74- Bommakanti V, Banerjee M, Shah D, Manisha K, Sri K, Banerjee S. An overview of synthesis, characterization, applications and associated adverse effects of bioactive nanoparticles. Environmental Research. 2022;214:113919 [Crossref]
75- Bergin P, Leggett A, Cardwell C, Woodside J, Thakkinstian A, Maxwell A, McKay G. The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis. BMC Nephrol. 2021;22(1) [Crossref]


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge