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Bioimpacts. 2017;7(4): 219-226. doi: 10.15171/bi.2017.26
PMID: 29435429        PMCID: PMC5801533

Original Research

Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition

Aysa Rezabakhsh 1,2, Soheila Montazersaheb 2,3, Elahe Nabat 2, Mehdi Hassanpour 4, Azadeh Montaseri 5, Hassan Malekinejad 6,7, Ali Akbar Movassaghpour 8, Reza Rahbarghazi 2,9 * , Alireza Garjani 1,2 *

Cited by CrossRef: 21

1- Govindarajulu M, Ramesh S, Beasley M, Lynn G, Wallace C, Labeau S, Pathak S, Nadar R, Moore T, Dhanasekaran M. Role of cGAS–Sting Signaling in Alzheimer’s Disease. IJMS. 2023;24(9):8151 [Crossref]
2- Yuan Z, Cai J, Du Q, Ma Q, Xu L, Cai Y, Zhong X, Guo X. Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy . Crit Rev Eukaryot Gene Expr. 2023;33(6):43 [Crossref]
3- Hassanpour M, Rezabakhsh A, Pezeshkian M, Rahbarghazi R, Nouri M. Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells. Stem Cell Res Ther. 2018;9(1) [Crossref]
4- Gajić M, Schröder-Heurich B, Mayer-Pickel K. Deciphering the immunological interactions: targeting preeclampsia with Hydroxychloroquine’s biological mechanisms. Front Pharmacol. 2024;15 [Crossref]
5- Bagheri Y, Sadigh-Eteghad S, Fathi E, Mahmoudi J, Abdollahpour A, Namini N, Malekinejad Z, Mokhtari K, Barati A, Montazersaheb S. Hepatoprotective effects of sericin on aging-induced liver damage in mice. Naunyn-Schmiedeberg's Arch Pharmacol. 2021;394(12):2441 [Crossref]
6- Colapietro A, Rossetti A, Mancini A, Martellucci S, Ocone G, Pulcini F, Biordi L, Cristiano L, Mattei V, Delle Monache S, Marampon F, Gravina G, Festuccia C. Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma. Pharmaceuticals. 2021;14(11):1082 [Crossref]
7- Basri N, Murthi P, Abd Rahman R. Hydroxychloroquine as an Adjunct Therapy for Diabetes in Pregnancy. IJMS. 2024;25(17):9681 [Crossref]
8- Zakaria S, Elsebaey S, Allam S, El-Sisi A. Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells. Biomedicine & Pharmacotherapy. 2022;154:113562 [Crossref]
9- Wu J. Tackle the free radicals damage in COVID-19. Nitric Oxide. 2020;102:39 [Crossref]
10- Haiaty S, Rashidi M, Akbarzadeh M, Bazmani A, Mostafazadeh M, Nikanfar S, Zibaei Z, Rahbarghazi R, Nouri M. Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells. BMC Complement Med Ther. 2021;21(1) [Crossref]
11- Nensat C, Songjang W, Tohtong R, Suthiphongchai T, Phimsen S, Rattanasinganchan P, Metheenukul P, Kumphune S, Jiraviriyakul A. Porcine placenta extract improves high-glucose-induced angiogenesis impairment. BMC Complement Med Ther. 2021;21(1) [Crossref]
12- Hassanpour M, Cheraghi O, Rahbarghazi R, Nouri M. Autophagy stimulation delayed biological aging and decreased cardiac differentiation in rabbit mesenchymal stem cells. J Cardiovasc Thorac Res. 2021;13(3):234 [Crossref]
13- El-Samad L, Maklad A, Elkady A, Hassan M. Unveiling the mechanism of sericin and hydroxychloroquine in suppressing lung oxidative impairment and early carcinogenesis in diethylnitrosamine-induced mice by modulating PI3K/Akt/Nrf2/NF-κB signaling pathway. Biomedicine & Pharmacotherapy. 2025;182:117730 [Crossref]
14- Lee Y. Efficacy of hydroxychloroquine for knee osteoarthritis. Korean J Intern Med. 2022;37(1):51 [Crossref]
15- Bowen D, Pathak S, Nadar R, Parise R, Ramesh S, Govindarajulu M, Moore A, Ren J, Moore T, Dhanasekaran M. Oxidative stress and COVID-19-associated neuronal dysfunction: mechanisms and therapeutic implications. ABBS. 2023;55(8):1153 [Crossref]
16- Gupta A. Real-World Clinical Effectiveness and Tolerability of Hydroxychloroquine 400 Mg in Uncontrolled Type 2 Diabetes Subjects who are not Willing to Initiate Insulin Therapy (HYQ-Real-World Study). CDR. 2019;15(6):510 [Crossref]
17- Moghimi N, Rahimi E, Eslamipour J, Reshadmanesh N, Saeidi A. Evaluation Incidence of Ocular Complications of Hydroxychloroquine and Related Risk Factors in Patients with Connective Tissue Disease Referred to the Rheumatology Clinic of Tohid Hospital in Sanandaj. SJKU. 2023;28(1):55 [Crossref]
18- Rahbarghazi R, Farhoudi M, Rahmani-Youshanlouei H, Hassanpour M, Rahbarghazi A, Rezaie J, Ahmadi M. Putative effect of melatonin on cardiomyocyte senescence in mice with type 1 diabetes mellitus. J Diabetes Metab Disord. 2022;21(1):353 [Crossref]
19- Yahalomi T, Pikkel Y, Arnon R, Porat D, Pikkel J. The HIT Study—The Hydroxychloroquine Effect in the Treatment of Patients with Age-Related Macular Degeneration: A Randomized Controlled Trial. Medicina. 2023;59(3):551 [Crossref]
20- Gajić M, Schröder-Heurich B, Horvat Mercnik M, Cervar-Zivkovic M, Wadsack C, von Versen-Höynck F, Mayer-Pickel K. The Impact of Hydroxychloroquine on Primary Feto-Placental Endothelial Cells from Healthy and Early-Onset Preeclamptic Placentas. IJMS. 2023;24(13):10934 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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