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Bioimpacts. 2017;7(1): 59-71. doi: 10.15171/bi.2017.08
PMID: 28546954        PMCID: PMC5439391

Review

Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy

Farnaz Fahimi 1, Mohammad Reza Tohidkia 1, Mehdi Fouladi 1, Reza Aghabeygi 2, Naser Samadi 2, Yadollah Omidi 1,2,3 * ORCID

Cited by CrossRef: 17

1- Jalilzadeh-Razin S, Mantegi M, Tohidkia M, Pazhang Y, Pourseif M, Barar J, Omidi Y. Phage antibody library screening for the selection of novel high-affinity human single-chain variable fragment against gastrin receptor: an in silico and in vitro study. DARU J Pharm Sci. 2019;27(1):21 [Crossref]
2- Hong K, Ki M, Ullah H, Lee E, Kim Y, Chung M, Elfadl A, Park J, Jeong K. Preventive effect of anti-VacA egg yolk immunoglobulin (IgY) on Helicobacter pylori -infected mice. Vaccine. 2018;36(3):371 [Crossref]
3- Toh J, Wilson R. Pathways of Gastric Carcinogenesis, Helicobacter pylori Virulence and Interactions with Antioxidant Systems, Vitamin C and Phytochemicals. IJMS. 2020;21(17):6451 [Crossref]
4- Jain S, Sengupta M, Jain P. Non-Viral Parasites Associated with Carcinogenesis. Cancer Investigation. 2019;37(9):453 [Crossref]
5- Baral B, Kandpal M, Ray A, Jana A, Yadav D, Sachin K, Mishra A, Baig M, Jha H. Helicobacter pylori and Epstein-Barr virus infection in cell polarity alterations. Folia Microbiol. 2024;69(1):41 [Crossref]
6- Keikha M, Ali-Hassanzadeh M, Karbalaei M. Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis. BMC Gastroenterol. 2020;20(1) [Crossref]
7- Yu C, Qiu J, Xiong M, Ou C, Zeng M, Song H. Trends in Helicobacter pylori-related gastric ulcer research from 2012 to 2022: A bibliometric and visual analysis. Front Med. 2022;9 [Crossref]
8- Huang Z, Zhang X, Blaser M, London E. Helicobacter pylori lipids can form ordered membrane domains (rafts). Biochimica et Biophysica Acta (BBA) - Biomembranes. 2019;1861(11):183050 [Crossref]
9- Ahmed A, Besio R, Xiao L, Forlino A. Outer Membrane Vesicles (OMVs) as Biomedical Tools and Their Relevance as Immune-Modulating Agents against H. pylori Infections: Current Status and Future Prospects. IJMS. 2023;24(10):8542 [Crossref]
10- Fahimi F, Sarhaddi S, Fouladi M, Samadi N, Sadeghi J, Golchin A, Tohidkia M, Barar J, Omidi Y. Phage display-derived antibody fragments against conserved regions of VacA toxin of Helicobacter pylori. Appl Microbiol Biotechnol. 2018;102(16):6899 [Crossref]
11- Astl J, Holy R, Maute E, Rotnágl J, Kalfeřt D, Drnková B, Younus T, Pavlík E. Genome of Helicobacter pylori and Serotype of HPV Detected in Oropharyngeal and Laryngeal Cancer and Chronic Inflammation Patients. IJERPH. 2021;18(18):9545 [Crossref]
12- Bezerra T, Xavier K, Luz A, Cavalcanti I, Brito C, Balbino T. Prevalence of cagA, cagM, vacA and oipA genes in isolates of Helicobacter pylori obtained from hospital patients in Northeast Brazil. Braz J Microbiol. 2024; [Crossref]
13- Maleki Kakelar H, Barzegari A, Dehghani J, Hanifian S, Saeedi N, Barar J, Omidi Y. Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination. Gastric Cancer. 2019;22(1):23 [Crossref]
14- Barzigar R, Mehran M, Haraprasad N, Kumar B, Fakrudin B. Transient recombinant expression of highly immunogenic CagA, VacA and NapA in Nicotiana benthamiana. Biotechnology Reports. 2022;33:e00699 [Crossref]
15- Zou D, Xu L, Li H, Ma Y, Gong Y, Guo T, Jing Z, Xu X, Zhang Y. Role of abnormal microRNA expression inHelicobacter pyloriassociated gastric cancer. Critical Reviews in Microbiology. 2019;45(2):239 [Crossref]
16- Sukhan D, Vernygorodskyi S, Haidukov N, Ludkevich H. Molecular and Genetic Aspects of Helicobacter pylori Interaction with Cells of Gastric Mucosa. Cytol Genet. 2020;54(2):147 [Crossref]
17- Yeon M, Lee M, Kim D, Yang J, Woo H, Kwon H, Moon C, Kim S, Kim J. Anti-inflammatory effects of Kaempferol onHelicobacter pylori-induced inflammation. 2019;83(1):166 [Crossref]
18- Casarotto M, Pratesi C, Bidoli E, Maiero S, Magris R, Steffan A, Basaglia G, Canzonieri V, De Re V, Cannizzaro R, Zanussi S. Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk. Pathogens. 2019;8(2):65 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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