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Bioimpacts. 2015;5(1): 55-63. doi: 10.15171/bi.2015.04
PMID: 25901297        PMCID: PMC4401168

Review

Granulation techniques and technologies: recent progresses

Srinivasan Shanmugam 1 *

Cited by CrossRef: 206


1- Li W, Rezazadeh H, Sabi’u J, Akinyemi L, Inc M. On the Van der Waals model on granular matters with truncated M-fractional derivative. Opt Quant Electron. 2024;56(3) [Crossref]
2- Sohail Arshad M, Zafar S, Yousef B, Alyassin Y, Ali R, AlAsiri A, Chang M, Ahmad Z, Ali Elkordy A, Faheem A, Pitt K. A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing. Advanced Drug Delivery Reviews. 2021;178:113840 [Crossref]
3- Yanovska A, Artyukhov A, Vakal S, Vakal V, Shkola V. Encapsulated organic–mineral fertilizers with nanoporous structure. Appl Nanosci. 2022;12(4):1275 [Crossref]
4- Luz C, Sousa R, Pinto J, Doktorovová S. Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development. International Journal of Pharmaceutics. 2025;681:125821 [Crossref]
5- Spahn J, Zhang F. Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder. Drug Development and Industrial Pharmacy. 2020;46(12):1971 [Crossref]
6- Suresh P, Sreedhar I, Vaidhiswaran R, Venugopal A. A comprehensive review on process and engineering aspects of pharmaceutical wet granulation. Chemical Engineering Journal. 2017;328:785 [Crossref]
7- Dhondale M, Thakor P, Nambiar A, Singh M, Agrawal A, Shastri N, Kumar D. Co-Crystallization Approach to Enhance the Stability of Moisture-Sensitive Drugs. Pharmaceutics. 2023;15(1):189 [Crossref]
8- Bueva V, Blynskaya E, Alekseev K, Tishkov S, Minaev S. State of the art report on wet granulation technology. Pharmacy and Pharmaceutical Technology. 2023;(2):21 [Crossref]
9- Kim J, Park S, Lim J, Sohn S, Shin J, Park S, Jang Y, Chung E, Lee H, Lee K. Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury. 2017;67(4):479 [Crossref]
10- Mutch G, Hapgood K, Shen R, Selomulya C. An investigation on the dissolution qualities of foam granulated products. Powder Technology. 2019;343:693 [Crossref]
11- Khames A. Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique. Drug Delivery. 2017;24(1):328 [Crossref]
12- Khadka A, Giri B, Baral R, Shakya S, Shrestha A. Formulation and In Vitro Characterization of Cellulose-Based Propranolol Hydrochloride Sustained Release Matrix Tablets. BioChem. 2025;5(2):14 [Crossref]
13- Campos L, Pereira A, Cazarin C. The collagen market and knowledge, attitudes, and practices of Brazilian consumers regarding collagen ingestion. Food Research International. 2023;170:112951 [Crossref]
14- Alharby T, Alanazi J, Alanazi M, Huwaimel B. A novel combination of machine learning models and metaheuristic algorithm to predict important parameters of twin screw wet granulation process. Alexandria Engineering Journal. 2024;93:348 [Crossref]
15- Letona A, Ahn S, An S, Yun D, Kim Y, Muralles M, Chung D. High-Shear Granulation of Hygroscopic Probiotic-Encapsulated Skim Milk Powder: Effects of Moisture-Activation and Resistant Maltodextrin. Pharmaceuticals. 2023;16(2):217 [Crossref]
16- Ren B, Zhao Y, Ji B, Wei T, Shen C. Granulation of Drinking Water Treatment Residues: Recent Advances and Prospects. Water. 2020;12(5):1400 [Crossref]
17- Sriwidodo S, Pratama R, Umar A, Chaerunisa A, Ambarwati A, Wathoni N. Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability. Antioxidants. 2022;11(7):1331 [Crossref]
18- Gossard A, Henriet L, Vannier S, David T, Barré Y, Grandjean A. Emulsion synthetic route of hierarchically porous zeolite-geopolymer composites for Sr2+ decontamination in fixed bed process. Ceramics International. 2024;50(11):19692 [Crossref]
19- Liang D, Li Q, Du L, Dou G. Pharmacological Effects and Clinical Prospects of Cepharanthine. Molecules. 2022;27(24):8933 [Crossref]
20- Beringhs A, Fonseca A, De Campos A, Sonaglio D. Association of PLGA Microspheres to Carrier Pellets by Fluid Bed Coating: A Novel Approach towards Improving the Flowability of Microparticles. Journal of Pharmaceutics. 2018;2018:1 [Crossref]
21- Ouadaker M, Jiang X, Bowen P, Bienia M, Pagnoux C, Aimable A. Porous granules by freeze granulation of Pickering emulsions stabilized with halloysite particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020;585:124156 [Crossref]
22- Liu T, Kittikunakorn N, Zhang Y, Zhang F. Mechanisms of twin screw melt granulation. Journal of Drug Delivery Science and Technology. 2021;61:102150 [Crossref]
23- Gou J, Liu C, Lin J, Yu C, Fang Y, Liu Z, Guo Z, Tang C, Huang Y. Densification and pelletization of porous boron nitride fibers for effective CO2 adsorption. Ceramics International. 2022;48(8):11636 [Crossref]
24- Sharma S, Ahammed M. Application of modified water treatment residuals in water and wastewater treatment: A review. Heliyon. 2023;9(5):e15796 [Crossref]
25- Singlard M, Paillassa A, Ferres L, Pagnoux C, Aimable A. Freeze granulation and spray drying of mixed granules of Al2O3. Powder Technology. 2022;395:280 [Crossref]
26- Gresse E, Rousseau J, Akdim M, du Bois A, Lechanteur A, Evrard B. Enhancement of inhaled micronized powder flow properties for accurate capsules filling. Powder Technology. 2024;437:119576 [Crossref]
27- Ozkan C, Esim O, Savaser A, Ozkan Y. An Overview of Excipients Classification and Their Use in Pharmaceuticals. CPA. 2021;17(3):360 [Crossref]
28- Argalis P, Vitola L, Bajare D, Vegere K. Alkali-Activated Zeolite 4A Granules—Characterization and Suitability Assessment for the Application of Adsorption. Crystals. 2021;11(4):360 [Crossref]
29- Asachi M, Behjani M, Nourafkan E, Hassanpour A. Tailoring particle shape for enhancing the homogeneity of powder mixtures: Experimental study and DEM modelling. Particuology. 2021;54:58 [Crossref]
30- Fernandez-Diaz L, Castillo J, Sasieta-Barrutia E, Arnaiz M, Cabello M, Judez X, Terry A, Otaegui L, Morant-Miñana M, Villaverde A. Mixing methods for solid state electrodes: Techniques, fundamentals, recent advances, and perspectives. Chemical Engineering Journal. 2023;464:142469 [Crossref]
31- Bhatta S, Stevanovic Janezic T, Ratti C. Freeze-Drying of Plant-Based Foods. Foods. 2020;9(1):87 [Crossref]
32- Kelleher J, Madi A, Gilvary G, Tian Y, Li S, Almajaan A, Loys Z, Jones D, Andrews G, Healy A. Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology. AAPS PharmSciTech. 2020;21(1) [Crossref]
33- Momoniat F, Rahmanian N. Characterization of sulphur particles: prills vs. granules. Particulate Science and Technology. 2022;40(4):391 [Crossref]
34- Coldani M, Palugan L, Foppoli A, Cerea M, Pinto J. Evaluation of different techniques for wet granulation and pelletization processes using milk as innovative pharmaceutical excipient for pediatric use. International Journal of Pharmaceutics. 2024;666:124836 [Crossref]
35- Szulc A, Skotnicka E, Gupta M, Królczyk J. Powder agglomeration processes of bulk materials – A state of the art review on different granulation methods and applications. Powder Technology. 2024;431:119092 [Crossref]
36- Kallakunta V, Tiwari R, Sarabu S, Bandari S, Repka M. Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: A comparative study. European Journal of Pharmaceutical Sciences. 2018;121:126 [Crossref]
37- Vasconcelos T, Marques S, das Neves J, Sarmento B. Amorphous solid dispersions: Rational selection of a manufacturing process. Advanced Drug Delivery Reviews. 2016;100:85 [Crossref]
38- Chen C, Lee T. Round Granules of Dimethyl Fumarate by Three-in-One Intensified Process of Reaction, Crystallization, and Spherical Agglomeration in a Common Stirred Tank. Org Process Res Dev. 2017;21(9):1326 [Crossref]
39- Iwona S, Ewa S, Guminski R. Comparison of synthetic and natural binders supporting formation of granulated activated carbon. Desalination and Water Treatment. 2025;322:101077 [Crossref]
40- Li Z, Bai L, Li Y, Li M, Liu B, Sun Y, Zhang D, Fu Q. Cylindrical granules in the development of mesalazine solid formulations (Ⅰ): Physical properties, compression behaviors, and tableting performances. International Journal of Pharmaceutics. 2023;643:123208 [Crossref]
41- Klaas L, Eltayeb A, Kriechbaumer D, Roeb M, Sattler C. Ca1−xSrxMnO3−δ granules, pellets, foams: Influence of fabrication conditions and microstructure on oxidation kinetics. Solid State Ionics. 2025;422:116803 [Crossref]
42- Blanco D, Antikainen O, Räikkönen H, Yliruusi J, Juppo A. Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using image-based analysis. International Journal of Pharmaceutics. 2021;597:120344 [Crossref]
43- Wang J, Wang C, Wang Y, Dong M, You Y, Rong Z, Liu H, Zhang X, Zhu Z, Wang Y. Preparation of SiC /Yb2Si2O7 composite powders for environmental barrier coatings. Ceramics International. 2022;48(19):28072 [Crossref]
44- Artyukhov A, Artyukhova N, Krmela J, Krmelová V. Complex designing of granulation units with application of computer and software modeling: case “Vortex granulator”. IOP Conf Ser: Mater Sci Eng. 2020;776(1):012016 [Crossref]
45- Pradhan S, Dubey N, Shukla S, Pandey R, Gidwani B. A Review of the Fundamentals of Pharmaceutical Granulation Technology. Int J Pharm Phytopharmacol Res. 2023;13(2):1 [Crossref]
46- Wang L, Zhao L, Hong Y, Shen L, Lin X. Technological advances and challenges for exploring attribute transmission in tablet development by high shear wet granulation. Powder Technology. 2023;421:118402 [Crossref]
47- Minecka A, Tarnacka M, Soszka N, Hachuła B, Kamiński K, Kamińska E. Studying the Intermolecular Interactions, Structural Dynamics, and Non-Equilibrium Kinetics of Cilnidipine Infiltrated into Alumina and Silica Pores. Langmuir. 2023;39(1):533 [Crossref]
48- Kállai-Szabó N, Farkas D, Lengyel M, Basa B, Fleck C, Antal I. Microparticles and multi-unit systems for advanced drug delivery. European Journal of Pharmaceutical Sciences. 2024;194:106704 [Crossref]
49- Aponte M, Ungaro F, d'Angelo I, De Caro C, Russo R, Blaiotta G, Dal Piaz F, Calignano A, Miro A. Improving in vivo conversion of oleuropein into hydroxytyrosol by oral granules containing probiotic Lactobacillus plantarum 299v and an Olea europaea standardized extract. International Journal of Pharmaceutics. 2018;543(1-2):73 [Crossref]
50- Bonthagarala B, Dasari V, Kotra V. Solubility Enhancement Effect at Absorption Site on Bioavailability of Ritonavir Using Liquisolid Technique. Ther Deliv. 2019;10(5):295 [Crossref]
51- R K, M T, T S, V S. PREPARATION AND EVALUATION OF ACTIVE FILM COATING TABLET OF TENELIGLIPTIN HYDROBROMIDE HYDRATE WITH METFORMIN HYDROCHLORIDE FIXED DOSE COMBINATION. IND DRU. 2022;58(12):22 [Crossref]
52- Fernández-García R, Walsh D, O’Connell P, Passero L, de Jesus J, Laurenti M, Dea-Ayuela M, Ballesteros M, Lalatsa A, Bolás-Fernández F, Healy A, Serrano D. Targeted Oral Fixed-Dose Combination of Amphotericin B-Miltefosine for Visceral Leishmaniasis. Mol Pharmaceutics. 2025;22(3):1437 [Crossref]
53- Jovanovikj F, Miovska I, Popovska Jakimovska V, Gogu F, Stevanoska M, Atanasova A, Antovska P, Lazova J. Approaches for optimization of formulation and manufacturing process of low-dose tablets. Maced Pharm Bull. 2022;68(03):241 [Crossref]
54- Madarász L, Mészáros L, Köte Á, Farkas A, Nagy Z. AI-based analysis of in-line process endoscope images for real-time particle size measurement in a continuous pharmaceutical milling process. International Journal of Pharmaceutics. 2023;641:123060 [Crossref]
55- Rodin G. Thin axisymmetric power-law bridges squeezed by two rigid surfaces. Journal of Non-Newtonian Fluid Mechanics. 2022;308:104896 [Crossref]
56- Vadaga A, Gudla S, Nareboina G, Gubbala H, Golla B. Comprehensive review on modern techniques of granulation in pharmaceutical solid dosage forms. Intelligent Pharmacy. 2024;2(5):609 [Crossref]
57- Stoeckl G, Atxutegi A, Bellinghausen S, Heinrich S. Employing a multi-resonance microwave sensor for in-line moisture monitoring of fluidized bed agglomeration. Chemical Engineering Journal. 2024;499:156053 [Crossref]
58- Veronica N, Ang X, Ooi S, Liew C, Heng P. A Study on The Formulation of Plant Matrix Tablets From Coarse Botanical Materials Using Cinnamon Bark and Areca Nut as The Model Botanical Materials. psr. 2020;7(2) [Crossref]
59- Rao R, Pandey A, Hegde A, Kulkarni V, Chincholi C, Rao V, Bhushan I, Mutalik S. Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its Impact on Conventional Granulation Technology. AAPS PharmSciTech. 2022;23(1) [Crossref]
60- Zhang J, Cui H. Emulsion‐Tailored Pore Properties and Electrochemical Performance of Ni(OH)2 Spheres Using High Shear as Driving Force. Physica Status Solidi (a). 2020;217(15) [Crossref]
61- N, Yahaya N. Advanced Development of Bio-fertilizer Formulations Using Microorganisms as Inoculant for Sustainable Agriculture and Environment – A Review. MJoSHT. 2022;8(1):92 [Crossref]
62- Kumar D, Oka S, Emady H. Pre-nucleation in high-shear wet granulation. Powder Technology. 2024;437:119522 [Crossref]
63- Kaewpradit S, Chingunpitak J, Samhadthai W, Suppawattana T, Jantarat C. Comparison of Properties of Acetaminophen Tablets Prepared by Wet Granulation Using Freeze-Dried Versus Phase-Inversion Bacterial Cellulose as Diluent. AAPS PharmSciTech. 2024;25(2) [Crossref]
64- Yusni N, Effendi T, Hazizul Hasan M. Subacute Toxicity of Microgranulated Myrmecodia platytyrea Aqueous Tuber Extract (gMPAE). MJMHS. 2023;19(s12):38 [Crossref]
65- Lorignon F, Gossard A, Carboni M. Hierarchically porous monolithic MOFs: An ongoing challenge for industrial-scale effluent treatment. Chemical Engineering Journal. 2020;393:124765 [Crossref]
66- de Andrade D, de Oliveira E, Pohlmann A, Guterres S, Külkamp-Guerreiro I, Beck R. Fluid bed granulation as an innovative process to produce dry redispersible nanocapsules: Influence of cationic coating of particles. Powder Technology. 2018;326:25 [Crossref]
67- Rostocki A, Unyay H, Ławińska K, Obraniak A. Granulates Based on Bio and Industrial Waste and Biochar in a Sustainable Economy. Energies. 2022;16(1):56 [Crossref]
68- Baral K, Bajracharya R, Lee S, Han H. Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology. IJN. 2021;Volume 16:7535 [Crossref]
69- Erdemir D, Rosenbaum T, Chang S, Wong B, Kientzler D, Wang S, Desai D, Kiang S. Novel Co-processing Methodology To Enable Direct Compression of a Poorly Compressible, Highly Water-Soluble Active Pharmaceutical Ingredient for Controlled Release. Org Process Res Dev. 2018;22(10):1383 [Crossref]
70- Moraes de Souza C, Tanir T, Orellana M, Escalante A, Koeris M. Manufacturing Bacteriophages (Part 2 of 2): Formulation, Analytics and Quality Control Considerations. Pharmaceuticals. 2021;14(9):895 [Crossref]
71- Gökpinar S, Ernst S, Hastürk E, Möllers M, El Aita I, Wiedey R, Tannert N, Nießing S, Abdpour S, Schmitz A, Quodbach J, Füldner G, Henninger S, Janiak C. Air-Con Metal–Organic Frameworks in Binder Composites for Water Adsorption Heat Transformation Systems. Ind Eng Chem Res. 2019;58(47):21493 [Crossref]
72- Gowing S, Sabu U, Bordia R. Warm Pressing of Organosilicon Polymer Toward Monolithic Ceramics. Adv Eng Mater. 2024; [Crossref]
73- Magalhães A, Toma H, do Carmo F, Mansur C. Development of purified cashew gum mucoadhesive buccal tablets containing nystatin for treatment of oral candidiasis. Drug Development and Industrial Pharmacy. 2021;47(5):825 [Crossref]
74- Zhao W, Xie H, Li J, Zhang L, Zhao Y. Application of Alum Sludge in Wastewater Treatment Processes: “Science” of Reuse and Reclamation Pathways. Processes. 2021;9(4):612 [Crossref]
75- Barba A, Dalmoro A, Bochicchio S, De Simone V, Caccavo D, Iannone M, Lamberti G. Engineering approaches for drug delivery systems production and characterization. International Journal of Pharmaceutics. 2020;581:119267 [Crossref]
76- Wang B, Li H, Xiang J, Zheng J, Wang J, Hong T. Fabrication of Agglomerated Lactose Using Fluidized Bed for Good Compressibility. Journal of Nanomaterials. 2021;2021:1 [Crossref]
77- P, AGARWAL V, AGARWAL A. AN OVERVIEW ON MOUTH DISSOLVING TABLET: FROM MANUFACTURING AND PATENTED TECHNIQUE TO QUALITY CONTROL TEST. Asian J Pharm Clin Res. 2022;:7 [Crossref]
78- Kubová K, Franc A, Vysloužil J, Šaloun J, Vetchý D. New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications. Čes slov farm. 2019;68(4):139 [Crossref]
79- Lim D, Letona A, Lee M, Lim D, Han N, Chung D. Fluidized-Bed Granulation of Probiotics-Encapsulated Spray-Dried Skim Milk Powder: Effects of a Fluidizing Aid, Moisture-Activation and Dehydration. Foods. 2021;10(7):1600 [Crossref]
80- Argalis P, Jerane I, Zhurinsh A, Vegere K. Assessment of Different Binders for Activated Carbon Granulation for the Use in CO2 Adsorption. 2021;25(1):1086 [Crossref]
81- Fekete R, Peciar P, Juriga M, Gužela Š, Peciarová M, Horváth D, Peciar M. Pressure and Liquid Distribution under the Blade of a Basket Extruder of Continuous Wet Granulation of Model Material. JMMP. 2024;8(3):127 [Crossref]
82- Origoni M, Nardi-Ricart A, Suñé-Pou M, Pérez-Lozano P, Romero-Obón M, Negre J, Ochoa-Andrade A, Montoya E. Exploration of moisture activated dry granulation for the development of gastroretentive tablets aided by SeDeM diagram. European Journal of Pharmaceutics and Biopharmaceutics. 2024;203:114456 [Crossref]
83- Kotamarthy L, Karkala S, Dan A, Román-Ospino A, Ramachandran R. Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map. Pharmaceutics. 2024;16(4):456 [Crossref]
84- Koyanagi K, Ueno A, Sasaki T, Otsuka M. Real-Time Monitoring of Critical Quality Attributes during High-Shear Wet Granulation Process by Near-Infrared Spectroscopy Effect of Water Addition and Stirring Speed on Pharmaceutical Properties of the Granules. Pharmaceuticals. 2022;15(7):822 [Crossref]
85- Sadraei H, Rasouli-Amirabadi A, Yekdaneh A, Tavakoli N. Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi . J Herbmed Pharmacol. 2022;11(3):435 [Crossref]
86- Miao T, Zhi F, Yang X, Yuan Z, Zhang C, Feng Y, Wei H, Jiang H, Gao B, Zhang L. Break through the thermostability of glucose oxidase in extremely thermal environments with a novel dynamic ensemble design protocol. Process Biochemistry. 2025;148:55 [Crossref]
87- Abu Fara D, Al-Hmoud L, Rashid I, Chowdhry B, Badwan A. Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. Marine Drugs. 2020;18(2):115 [Crossref]
88- Zhao Y, Nzihou A, Ren B, Lyczko N, Shen C, Kang C, Ji B. Waterworks Sludge: An Underrated Material for Beneficial Reuse in Water and Environmental Engineering. Waste Biomass Valor. 2021;12(8):4239 [Crossref]
89- Askarishahi M, Salehi M, Maus M, Schröder D, Slade D, Jajcevic D. Mechanistic modelling of fluid bed granulation, Part II: Eased process development via degree of wetness. International Journal of Pharmaceutics. 2019;572:118836 [Crossref]
90- Person M, Cuq B, Duri A, Le Floch-Fouéré C, Jeantet R, Schuck P. Steam-jet agglomeration of skim milk powders: Influence of process parameters. Drying Technology. 2018;36(15):1930 [Crossref]
91- Qian Y, Usher S, Scales P, Stickland A, Alexiadis A. Modeling capillary-driven particle agglomeration under shear in immiscible fluids using discrete multiphysics. 2025;37(3) [Crossref]
92- Wong C, Martinez J, Dass C. Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities. 2016;68(9):1093 [Crossref]
93- Awad M, López-Galindo A, Setti M, El-Rahmany M, Iborra C. Kaolinite in pharmaceutics and biomedicine. International Journal of Pharmaceutics. 2017;533(1):34 [Crossref]
94- Kulinowski P, Woyna-Orlewicz K, Obrał J, Rappen G, Haznar-Garbacz D, Węglarz W, Jachowicz R, Wyszogrodzka G, Klaja J, Dorożyński P. Multimodal approach to characterization of hydrophilic matrices manufactured by wet and dry granulation or direct compression methods. International Journal of Pharmaceutics. 2016;499(1-2):263 [Crossref]
95- Minecka A, Tarnacka M, Jurkiewicz K, Żakowiecki D, Kamiński K, Kamińska E. Mesoporous Matrices as a Promising New Generation of Carriers for Multipolymorphic Active Pharmaceutical Ingredient Aripiprazole. Mol Pharmaceutics. 2023;20(11):5655 [Crossref]
96- Czuma N, Panek R, Baran P, Zarębska K. The influence of binders for the pelletization of fly ash zeolites on sulfur dioxide sorption properties. Clay miner. 2020;55(1):40 [Crossref]
97- Byeon J, Ahn J, Jang W, Lee S, Choi J, Park J. Recent formulation approaches to oral delivery of herbal medicines. J Pharm Investig. 2019;49(1):17 [Crossref]
98- Xu J, Liu Y, Wang M, Li J, Cui H. High shear-granulated hierarchically porous spheres nanostructure-designed for high-performance supercapacitors. Advanced Powder Technology. 2019;30(10):2440 [Crossref]
99- Jamieson W. For granular geography. Dialogues in Human Geography. 2021;11(2):275 [Crossref]
100- da Silva R, Fante A, Silva A, Pereira F, Gutierrez Y, Ferraz H. Wet powder rheometry: The best conditions for wet granulation using diluent and binder in calcium carbonate samples. Powder Technology. 2022;397:117087 [Crossref]
101- Gawshinde A. Formulation, development and evaluation of paracetamol tablet by moisture activated dry granulation (MADG) process. JPBS. 2024;12(1):60 [Crossref]
102- Xu T, Nahar K, Dave R, Bates S, Morris K. Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control. Pharm Res. 2018;35(7) [Crossref]
103- Eremin V, Blynskaya E, Tishkov S. Selection of excipients for the formulation of varenicline tablet cores. Pharmacy and Pharmaceutical Technology. 2024;(1):36 [Crossref]
104- Isaac J, Ekere K, Ezekiel E, Galadima I, Abdulahi R, Samali A. Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves. Borneo J Pharm. 2021;4(4):333 [Crossref]
105- Jiménez-Saelices C, Seantier B, Cathala B, Grohens Y. Spray freeze-dried nanofibrillated cellulose aerogels with thermal superinsulating properties. Carbohydrate Polymers. 2017;157:105 [Crossref]
106- Khaled A, Abdel-Hamid S, Nasr M, Sammour O. Fabrication of extended-dissolution divalproex tablets: a green solvent-free granulation technique. Drug Development and Industrial Pharmacy. 2020;46(6):975 [Crossref]
107- Liu B, Wang J, Zeng J, Zhao L, Wang Y, Feng Y, Du R. A review of high shear wet granulation for better process understanding, control and product development. Powder Technology. 2021;381:204 [Crossref]
108- Zidan A, Kotamarthy L, Ramachandran R, Ashraf M, O'Connor T. Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets. International Journal of Pharmaceutics. 2022;623:121964 [Crossref]
109- De A, Wilson P, Wallstén S, Akhtar F. High-shear wet granulation of alumina with expanded Microspheres: Role of bio-based binders. Ceramics International. 2025; [Crossref]
110- Mady O, Thabit S, Abo Elnasr S, Hedaya A. An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence. Sci Rep. 2023;13(1) [Crossref]
111- Sarabu S, Kallakunta V, Butreddy A, Janga K, Ajjarapu S, Bandari S, Zhang F, Murthy S, Repka M. A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the Solubility of Poorly Soluble Drugs: Effect of Formulation Variables on Dissolution and Stability. AAPS PharmSciTech. 2021;22(3) [Crossref]
112- Horibe M, Sonoda R, Watano S. Scale-up of Mixing Process for Low Drug Content Formulation. Funtai Kogakkaishi. 2020;57(1):12 [Crossref]
113- Artyukhov A, Krmela J, Krmelová V, Ospanov D. Vortex-Type Granulation Machines: Technological Basis of Calculation and Implementation Roadmap. 2022;16(4):347 [Crossref]
114- Nagasamy Venkatesh D, Meyyanathan S, Shanmugam R, Kamatham S, Campos J, Dias-Ferreira J, Sanchez-Lopez E, Cardoso J, Severino P, Souto E. Physicochemical, pharmacokinetic, and pharmacodynamic characterization of isradipine tablets for controlled release. Pharmaceutical Development and Technology. 2021;26(1):92 [Crossref]
115- Skoczko I, Szatyłowicz E, Tabor A, Gumiński R. Manufacturing Options for Activated Carbons with Selected Synthetic Polymers as Binders. Materials. 2024;17(8):1753 [Crossref]
116- Fujimoto Y, Hirai N, Takatani-Nakase T, Takahashi K. Novel tablet formulation of amorphous indomethacin using wet granulation with a high-speed mixer granulator combined with porous calcium silicate. Journal of Drug Delivery Science and Technology. 2016;33:51 [Crossref]
117- Alves A, Simões M, Simões S, Gomes J. A review on the scale-up of high-shear wet granulation processes and the impact of process parameters. Particuology. 2024;92:180 [Crossref]
118- Borowski G, Ozga M. Comparison of the processing conditions and the properties of granules made from fly ash of lignite and coal. Waste Management. 2020;104:192 [Crossref]
119- Osouli-Bostanabad K, Masalehdan T, Kapsa R, Quigley A, Lalatsa A, Bruggeman K, Franks S, Williams R, Nisbet D. Traction of 3D and 4D Printing in the Healthcare Industry: From Drug Delivery and Analysis to Regenerative Medicine. ACS Biomater Sci Eng. 2022;8(7):2764 [Crossref]
120- Bhujbal S, Mitra B, Jain U, Gong Y, Agrawal A, Karki S, Taylor L, Kumar S, (Tony) Zhou Q. Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies. Acta Pharmaceutica Sinica B. 2021;11(8):2505 [Crossref]
121- Riley B. A Multifunctional Technology Platform for Sorbent Construction Using Polyacrylonitrile Scaffolds. Ind Eng Chem Res. 2024;63(19):8647 [Crossref]
122- Abdelkader A, Moos C, Pelloux A, Pfeiffer M, Alter C, Kolling S, Keck C. Tablets Made from Paper—An Industrially Feasible Approach. Pharmaceuticals. 2022;15(10):1188 [Crossref]
123- Erdemir D, Daftary V, Lindrud M, Buckley D, Lane G, Malsbury A, Tao J, Kopp N, Hsieh D, Nikitczuk W, Engstrom J. Design and Scale-up of a Co-processing Technology to Improve Powder Properties of Drug Substances. Org Process Res Dev. 2019;23(12):2685 [Crossref]
124- Maharjan R, Lee J, Kim N, Jeong S. Preparation of seeded granules to improve mechanical properties and various drug loading for pharmaceutical application. Powder Technology. 2021;392:650 [Crossref]
125- Vlad R, Pintea C, Chirteș D, Antonoaea P, Rédai E, Todoran N, Bîrsan M, Ciurba A. The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations. Pharmaceutics. 2023;15(8):2147 [Crossref]
126- Fonseca J, Gong T. Fabrication of metal-organic framework architectures with macroscopic size: A review. Coordination Chemistry Reviews. 2022;462:214520 [Crossref]
127- Monsanto P, Koleilat L, Gupta S, Butikofer S, Mort P, Wade J. Formulation in a drop - Templated granulation and compaction analysis. Powder Technology. 2024;438:119611 [Crossref]
128- Ding X, Zeinali Danalou S, Zhang L, Zhu N. In situ wet pharmaceutical granulation captured using synchrotron radiation based dynamic micro-CT. J Synchrotron Rad. 2023;30(2):430 [Crossref]
129- Helal N, Elnoweam O, Eassa H, Amer A, Eltokhy M, Helal M, Fayyaz H, Nounou M. Integrated Continuous Manufacturing in Pharmaceutical Industry: Current Evolutionary Steps Toward Revolutionary Future. Pharm Pat Anal. 2019;8(4):139 [Crossref]
130- Krstic M, Djuris J, Petrovic O, Lazarevic N, Cvijic S, Ibric S. Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. Journal of Drug Delivery Science and Technology. 2017;39:467 [Crossref]
131- Abrosimova O, Burakova M. Scaling of the Granulation Process in the Conditions of GMP Training Center and Assessment of Possible Risks. Razrabotka i registraciâ lekarstvennyh sredstv. 2021;10(3):131 [Crossref]
132- Dubey V, Jaiswal M, Puri R, Arora V. Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release tablets. Materials Today: Proceedings. 2022;68:774 [Crossref]
133- Thapa P, Tripathi J, Jeong S. Recent trends and future perspective of pharmaceutical wet granulation for better process understanding and product development. Powder Technology. 2019;344:864 [Crossref]
134- Kotamarthy L, Ramachandran R. Mechanistic understanding of the effects of process and design parameters on the mixing dynamics in continuous twin-screw granulation. Powder Technology. 2021;390:73 [Crossref]
135- Mady O, Al-Shoubki A, Donia A. An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design. DDDT. 2021;Volume 15:4469 [Crossref]
136- Grzanka M, Joniec A, Rogulski J, Sobiech Ł, Idziak R, Loryś B. Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control. 2024;19(1) [Crossref]
137- Liu Y, Huang J, Zhang X. Progress of lightweight and robust ceramsite from solid waste: Preparation, properties and applications. Construction and Building Materials. 2025;482:141601 [Crossref]
138- Rosseau L, Middelkoop V, Willemsen H, Roghair I, van Sint Annaland M. Review on Additive Manufacturing of Catalysts and Sorbents and the Potential for Process Intensification. Front Chem Eng. 2022;4 [Crossref]
139- Mamidi H, Palekar S, Nukala P, Mishra S, Patki M, Fu Y, Supner P, Chauhan G, Patel K. Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE). International Journal of Pharmaceutics. 2021;593:120101 [Crossref]
140- Durán E, Bueno S, Hermosín M, Cox L, Gámiz B. Optimizing a low added value bentonite as adsorbent material to remove pesticides from water. Science of The Total Environment. 2019;672:743 [Crossref]
141- Zhong L, Gao L, Li L, Zang H. Trends-process analytical technology in solid oral dosage manufacturing. European Journal of Pharmaceutics and Biopharmaceutics. 2020;153:187 [Crossref]
142- Osorio J, Sayin R, Kalbag A, Litster J, Martinez‐Marcos L, Lamprou D, Halbert G. Scaling of continuous twin screw wet granulation. AIChE Journal. 2017;63(3):921 [Crossref]
143- Zakowiecki D, Edinger P, Papaioannou M, Hess T, Kubiak B, Terlecka A. Exploiting synergistic effects of brittle and plastic excipients in directly compressible formulations of sitagliptin phosphate and sitagliptin hydrochloride. Pharmaceutical Development and Technology. 2022;27(6):702 [Crossref]
144- Hammad R, Khan I, Asghar S, Khalid S, Irfan M, Khalid I, Shah S, Sabir N, Ali A, Yousaf A, Hussain T, Shahzad Y, Gohar U. Multistage release matrices for potential antiplatelet therapy: Assessing the impact of polymers and Sorb-Cel M® on floating, swelling, and release behavior. Journal of Drug Delivery Science and Technology. 2020;55:101387 [Crossref]
145- Wang L, Huang G, Ma W, Jin G. Preparation and Application of Directed Vat Set Indigenous Freeze-Drying Lentilactobacillus hilgardii Q19 Starter in Winemaking. Foods. 2023;12(5):1053 [Crossref]
146- Pandey P, Levins C, Pafiakis S, Zacour B, Bindra D, Trinh J, Buckley D, Gour S, Sharif S, Stamato H. Enhancing tablet disintegration characteristics of a highly water-soluble high-drug-loading formulation by granulation process. Pharmaceutical Development and Technology. 2018;23(6):587 [Crossref]
147- Ntamo D, Papadopoulos I, Omar C, Soulatiantork P, Zandi M. A Sustainability-Oriented Digital Twin of the Diamond Pilot Plant. Processes. 2025;13(1):211 [Crossref]
148- Nikolovska V, Davcheva M. Roller compaction technology. Maced Pharm Bull. 2022;68(03):281 [Crossref]
149- Martínez E, Gamboa J, Finkielstein C, Cañas A, Osorio M, Vélez Y, Llinas N, Castro C. Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications. J Mater Sci: Mater Med. 2025;36(1) [Crossref]
150- Iqbal N, Agrawal A, Kumar J. Development of effervescent tablet formulation for rapid control of mosquito problem in early stages from different breeding sites. Arabian Journal of Chemistry. 2021;14(4):103082 [Crossref]
151- Song W, Han C, Yu W, Jang J, Kim G, Jeon Y, Kim Y, Jeong S, Kang J, Kim D, Park Y, Park C. Formulation and Bioequivalence Evaluation of a Miniaturized Fexofenadine Hydrochloride Tablet. Pharmaceutics. 2025;17(6):756 [Crossref]
152- Bhuyar S, Auti M, Bhise S, Radal P, Gore P, Sapkal S, Dhongade H. Innovations and advancements in floating tablet drug delivery systems: a comprehensive review. PPIJ. 2024;12(5):195 [Crossref]
153- Cui T, Hou Y, Feng H, Wu S, Li W, Li Z. Granulation process analysis technologies and potential applications in traditional Chinese medicine. 2022;2(1):9 [Crossref]
154- Garcia-Radilla A, Ortiz-Reynoso M, Santillán-Benítez J, Alcantara-Fierro E. Dispersiones sólidas de solubilidad mejorada fabricadas en mezcladores de alto corte: una oportunidad para la industria farmacéutica local mexicana. Rev Colomb Cienc Quím Farm. 2023;52(1) [Crossref]
155- Chen B, Huang P, Zhou J, Li M. An Enhanced Stacking Ensemble Method for Granule Moisture Prediction in Fluidized Bed Granulation. Processes. 2022;10(4):725 [Crossref]
156- Scalize P, Albuquerque A, Di Bernardo L. Impact of Alum Water Treatment Residues on the Methanogenic Activity in the Digestion of Primary Domestic Wastewater Sludge. Sustainability. 2021;13(16):8783 [Crossref]
157- Yıldız S, Aytekin E, Yavuz B, Bozdağ Pehlivan S, Ünlü N. Formulation studies for mirtazapine orally disintegrating tablets. Drug Development and Industrial Pharmacy. 2016;42(6):1008 [Crossref]
158- Vanza J, Patel R, Dave R, Patel M. Polyethylene oxide and its controlled release properties in hydrophilic matrix tablets for oral administration. Pharmaceutical Development and Technology. 2020;25(10):1169 [Crossref]
159- Jairen A, Aris A, Nuid M, Zaidi N, Chelliapan S, Hasan H, Moszakir M. Cultivation of Aerobic Granules in a Small H/D Reactor with Influence of Static Mixer. IOP Conf Ser: Earth Environ Sci. 2025;1505(1):012013 [Crossref]
160- Sharma P, Sebastian J, Ghosh S, Creaser D, Olsson L. Recent advances in hydrogenation of CO2 into hydrocarbons via methanol intermediate over heterogeneous catalysts. Catal Sci Technol. 2021;11(5):1665 [Crossref]
161- Hansen M, Hartel R, Roos Y. Formation of dry beads for bioactives encapsulation by freeze granulation. Journal of Food Engineering. 2022;317:110847 [Crossref]
162- Panthi V, Jha S, Chaubey R, Pangeni R, Denizli A. Formulation and development of Serratiopeptidase enteric coated tablets and analytical method validation by UV Spectroscopy. International Journal of Analytical Chemistry. 2021;2021:1 [Crossref]
163- Cho H, Kim R, Jung H, Han J, Jung I, Ryu J. Optimization of freeze granulation and sintering behavior of MgO granules for thermal interface materials. Ceramics International. 2024;50(1):2128 [Crossref]
164- G J, Kamavarapu U, Muthyala H, M S. A Comprehensive Study on Pharmaceutical Mini Tablets and Pellets. AJPS. 2024;:287 [Crossref]
165- Person M, Cuq B, Duri A, Le Floch-Fouéré C, Schuck P, Jeantet R. Influence of the drying step in the steam-jet granulation process of dairy powders. Journal of Food Engineering. 2018;239:33 [Crossref]
166- Shiekmydeen J, Shiekmydeen T, Sharma S, Chakraborty K, Kannaiyan D, Khan N, Malayandi R. Optimization of wet granulation process for manufacturing Rivaroxban generic immediate-release tablets using PBPK modeling and simulations. In Silico Pharmacol. 2024;12(2) [Crossref]
167- Artyukhov A, Artyukhova N, Krmela J, Krmelova V. Ammonium nitrate with nanoporous structure: production methods, phase composition and morphological features of the surface. Appl Nanosci. 2022;12(4):1213 [Crossref]
168- Jannini E, Vignesh S, Hassan T. Next-generation pharmaceuticals: the rise of sildenafil citrate ODF for the treatment of men with erectile dysfunction. Therapeutic Delivery. 2025;16(4):365 [Crossref]
169- Wang H, Mustaffar A, Phan A, Zivkovic V, Reay D, Law R, Boodhoo K. A review of process intensification applied to solids handling. Chemical Engineering and Processing: Process Intensification. 2017;118:78 [Crossref]
170- Liu Y, Thompson M, O'Donnell K, Ali S. Heat assisted twin screw dry granulation. AIChE Journal. 2017;63(11):4748 [Crossref]
171- Ghourichay M, Kiaie S, Nokhodchi A, Javadzadeh Y, Yuksel N. Formulation and Quality Control of Orally Disintegrating Tablets (ODTs): Recent Advances and Perspectives. BioMed Research International. 2021;2021(1) [Crossref]
172- Ashokbhai M, Sanjay L, Sah S, Roy S, Kaity S. Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory filing. Drug Discovery Today. 2024;29(6):104011 [Crossref]
173- Pelletier J, Martel-Pelletier J. Diacerein-containing products: same risk of diarrhoea?. Aging Clin Exp Res. 2018;30(4):411 [Crossref]
174- Vijayakumar J, Goudarzi N, Eeckhaut G, Schrijnemakers K, Cnudde V, Boone M. Characterization of Pharmaceutical Tablets by X-ray Tomography. Pharmaceuticals. 2023;16(5):733 [Crossref]
175- Shi G, Lin L, Liu Y, Chen G, Luo Y, Wu Y, Li H. Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets. RSC Adv. 2021;11(14):8323 [Crossref]
176- Sharma L, Brigaityte O, Honer K, Kalfaoglu E, Slinksiene R, Streimikis V, Sviklas A, Baltrusaitis J. Carnallite-Derived Solid Waste as Potassium (K) and Magnesium (Mg) Source in Granulated Compound NPK Fertilizers. ACS Sustainable Chem Eng. 2018;6(7):9427 [Crossref]
177- Ilango K, Gowthaman S, Seramaan K, Chidambaram K, Bayan M, Rahamathulla M, Balakumar C. Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient. Polymers. 2022;14(1):215 [Crossref]
178- Wang B, Sun X, Xiang J, Guo X, Cheng Z, Liu W, Tan S. A critical review on granulation of pharmaceuticals and excipients: Principle, analysis and typical applications. Powder Technology. 2022;401:117329 [Crossref]
179- Marinko N, Sedlářová I, Römerová S, Gajdošová M, Zvoníček V, Zámostný P. Method to determine envelope density for roller compacted ribbons by solid displacement of glass microspheres. Powder Technology. 2024;444:120014 [Crossref]
180- Rezaei L, Meruva S, Donovan M. Effect of Manufacturing Process on the Retention of Abuse-Deterrent Properties of PEO-Matrix Tablets. AAPS PharmSciTech. 2022;23(1) [Crossref]
181- Trisopon K, Saokham P, Kittipongpatana N, Chomchoei N, Kittipongpatana O. Development of a multifunctional rice starch-based co-processed excipient for direct compression and colon-targeted drug delivery. Journal of Drug Delivery Science and Technology. 2025;112:107279 [Crossref]
182- Macho O, Kabát J, Gabrišová Ľ, Peciar P, Juriga M, Fekete R, Galbavá P, Blaško J, Peciar M. Dimensionless criteria as a tool for creation of a model for predicting the size of granules in high-shear granulation. Particulate Science and Technology. 2020;38(3):381 [Crossref]
183- Dégardin K, Guillemain A, Feng A, Saladin C, Paratte S, Zurbach R, Mohn T. Forensic analysis of counterfeit psychotropic drugs. Talanta Open. 2024;9:100295 [Crossref]
184- Lu Y, Xing S, He L, Li C, Wang X, Zeng X, Dai Y. Characterization, High-Density Fermentation, and the Production of a Directed Vat Set Starter of Lactobacilli Used in the Food Industry: A Review. Foods. 2022;11(19):3063 [Crossref]
185- Freville E, Pescheux-Sergienko J, Mujica R, Rey C, Bras J. Novel technologies for producing tridimensional cellulosic materials for packaging: A review. Carbohydrate Polymers. 2024;342:122413 [Crossref]
186- Kotamarthy L, Dan A, Karkala S, Parvani S, Román-Ospino A, Ramachandran R. Twin-screw granulation: Mechanistic understanding of the effect of material properties on key granule quality attributes through the analysis of mixing dynamics and granulation rate mechanisms. Advanced Powder Technology. 2023;34(9):104137 [Crossref]
187- Ye X, Kallakunta V, Kim D, Patil H, Tiwari R, Upadhye S, Vladyka R, Repka M. Effects of Processing on a Sustained Release Formulation Prepared by Twin-Screw Dry Granulation. Journal of Pharmaceutical Sciences. 2019;108(9):2895 [Crossref]
188- Xiao P, Guo Y, Wang J, Liu H, Zhang J, Wang Y, Yin T, Zhang Y, Gou J, He H, Tang X. The effect of granules characters on mechanical properties of press-coated tablets: A comparative study. International Journal of Pharmaceutics. 2022;624:121986 [Crossref]
189- Jermain S, Lowinger M, Ellenberger D, Miller D, Su Y, Williams R. In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer. Mol Pharmaceutics. 2020;17(8):2789 [Crossref]
190- Manna S, Sarkar S, Sahu R, Dua T, Paul P, Jana S, Nandi G. Characterization of Taro (Colocasia esculenta) stolon polysaccharide and evaluation of its potential as a tablet binder in the formulation of matrix tablet. International Journal of Biological Macromolecules. 2024;280:135901 [Crossref]
191- Nart V, Beringhs A, França M, de Espíndola B, Pezzini B, Stulzer H. Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs. Materials Science and Engineering: C. 2017;70:250 [Crossref]
192- Okeyo C, Chowdhury D, Cheung K, Rahmanian N. 3D printed elastic mould granulation. Powder Technology. 2019;344:380 [Crossref]
193- G V, Konda S. Phytochemical Screening and Evaluation of Anti Diabetic Activity Using Momordica charantia (Leaf & Stem) Extracts in Alloxan Induced Rats. Scopus Indexed. 2024;17(3):7386 [Crossref]
194- Moravkar K, Shah D, Magar A, Bhairav B, Korde S, Ranch K, Chalikwar S. Assessment of pharmaceutical powders flowability and comparative evaluation of lubricants on development of gastro retentive tablets: An application of powder flow tester. Journal of Drug Delivery Science and Technology. 2022;71:103265 [Crossref]
195- Maytakov A. Mathematical Model of Whey-Based Granulation Dispersed Mixtures Process in Disk-Type Devices. 2020;50(3):383 [Crossref]

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