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Bioimpacts. 2016;6(3): 169-181. doi: 10.15171/bi.2016.23
PMID: 27853680        PMCID: PMC5108989

Review

Radiolabeled theranostics: magnetic and gold nanoparticles

Saeideh Same 1, Ayuob Aghanejad 1, Sattar Akbari Nakhjavani 1,2, Jaleh Barar 1 ORCID, Yadollah Omidi 1 * ORCID

Cited by CrossRef: 73

1- Asgharzadeh M, Barar J, Pourseif M, Eskandani M, Jafari Niya M, Mashayekhi M, Omidi Y. Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy. Bioimpacts. 2017;7(2):115 [Crossref]
2- Theodorou I, Mpekris F, Papagiorgis P, Panagi M, Kalli M, Potamiti L, Kyriacou K, Itskos G, Stylianopoulos T. Gold Nanobipyramids for Near-Infrared Fluorescence-Enhanced Imaging and Treatment of Triple-Negative Breast Cancer. Cancers. 2023;15(14):3693 [Crossref]
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4- Perić M, Radović M, Mirković M, Nikolić A, Iskrenović P, Janković D, Vranješ-Đurić S. The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications. New J Chem. 2019;43(15):5932 [Crossref]
5- El-Safoury D, Ibrahim A, El-Setouhy D, Khowessah O, Motaleb M, Sakr T. Amelioration of Tumor Targeting and In Vivo Biodistribution of 99mTc-Methotrexate-Gold Nanoparticles (99mTc-Mex-AuNPs). Journal of Pharmaceutical Sciences. 2021;110(8):2955 [Crossref]
6- Fathi F, Rashidi M, Omidi Y. Ultra-sensitive detection by metal nanoparticles-mediated enhanced SPR biosensors. Talanta. 2019;192:118 [Crossref]
7- Safary A, Akbarzadeh Khiavi M, Mousavi R, Barar J, Rafi M. Enzyme replacement therapies: what is the best option?. Bioimpacts. 2018;8(3):153 [Crossref]
8- Stafford S, Serrano Garcia R, Gun’ko Y. Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications. Applied Sciences. 2018;8(1):97 [Crossref]
9- Xu X, Bayazitoglu Y, Meade A. Evaluation of theranostic perspective of gold-silica nanoshell for cancer nano-medicine: a numerical parametric study. Lasers Med Sci. 2019;34(2):377 [Crossref]
10- Fathi M, Majidi S, Zangabad P, Barar J, Erfan‐Niya H, Omidi Y. Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer. Medicinal Research Reviews. 2018;38(6):2110 [Crossref]
11- Shetty Y, Prabhu P, Prabhakar B. Emerging vistas in theranostic medicine. International Journal of Pharmaceutics. 2019;558:29 [Crossref]
12- Elmi G, Saleem K, Baig M, Aamir M, Wang M, Gao X, Abbas M, Rehman M. Recent Advances of Magnetic Gold Hybrids and Nanocomposites, and Their Potential Biological Applications. Magnetochemistry. 2022;8(4):38 [Crossref]
13- Zhang Z, Zhang Y, Song S, Yin L, Sun D, Gu J. Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals. J of Separation Science. 2020;43(9-10):1978 [Crossref]
14- Ahmadi M, Emzhik M, Mosayebnia M. Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging. Drug Deliv and Transl Res. 2023;13(6):1546 [Crossref]
15- Maccora D, Dini V, Battocchio C, Fratoddi I, Cartoni A, Rotili D, Castagnola M, Faccini R, Bruno I, Scotognella T, Giordano A, Venditti I. Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review. Applied Sciences. 2019;9(16):3232 [Crossref]
16- Jang B, Moorthy M, Manivasagan P, Xu L, Song K, Lee K, Kwak M, Oh J, Jin J. Fucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer. Oncotarget. 2018;9(16):12649 [Crossref]
17- Lin L, Starostin S, Li S, Hessel V. Synthesis of metallic nanoparticles by microplasma. 2018;3(10) [Crossref]
18- Muslimov A, Antuganov D, Tarakanchikova Y, Karpov T, Zhukov M, Zyuzin M, Timin A. An investigation of calcium carbonate core-shell particles for incorporation of 225Ac and sequester of daughter radionuclides: in vitro and in vivo studies. Journal of Controlled Release. 2021;330:726 [Crossref]
19- Fathi M, Barar J, Erfan-Niya H, Omidi Y. Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer. International Journal of Biological Macromolecules. 2020;154:1175 [Crossref]
20- Wu G, Zhu J, Weng G, Li J, Zhao J. Heterodimers of metal nanoparticles: synthesis, properties, and biological applications. Microchim Acta. 2021;188(10) [Crossref]
21- Nedyalkova M, Donkova B, Romanova J, Tzvetkov G, Madurga S, Simeonov V. Iron oxide nanoparticles – In vivo/in vitro biomedical applications and in silico studies. Advances in Colloid and Interface Science. 2017;249:192 [Crossref]
22- Shams S, Ghazanfari M, Schmitz-Antoniak C. Magnetic-Plasmonic Heterodimer Nanoparticles: Designing Contemporarily Features for Emerging Biomedical Diagnosis and Treatments. Nanomaterials. 2019;9(1):97 [Crossref]
23- Borran A, Aghanejad A, Farajollahi A, Barar J, Omidi Y. Gold nanoparticles for radiosensitizing and imaging of cancer cells. Radiation Physics and Chemistry. 2018;152:137 [Crossref]
24- Dai G, Wan W, Chen J, Wu J, Shuai X, Wang Y. Enhanced osteogenic differentiation of MC3T3-E1 on rhBMP-2 immobilized titanium surface through polymer-mediated electrostatic interaction. Applied Surface Science. 2019;471:986 [Crossref]
25- Pellico J, Gawne P, T. M. de Rosales R. Radiolabelling of nanomaterials for medical imaging and therapy. Chem Soc Rev. 2021;50(5):3355 [Crossref]
26- Aranda-Lara L, Morales-Avila E, Luna-Gutiérrez M, Olivé-Alvarez E, Isaac-Olivé K. Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy. Chemistry and Physics of Lipids. 2020;230:104934 [Crossref]
27- Gandhi S, Shende P. Anti-CD64 Antibody-Conjugated PLGA Nanoparticles Containing Methotrexate and Gold for Theranostics Application in Rheumatoid Arthritis. AAPS PharmSciTech. 2024;25(1) [Crossref]
28- Siminzar P, Omidi Y, Golchin A, Aghanejad A, Barar J. Targeted delivery of doxorubicin by magnetic mesoporous silica nanoparticles armed with mucin-1 aptamer. Journal of Drug Targeting. 2020;28(1):92 [Crossref]
29- Roy I, Krishnan S, Kabashin A, Zavestovskaya I, Prasad P. Transforming Nuclear Medicine with Nanoradiopharmaceuticals. ACS Nano. 2022;16(4):5036 [Crossref]
30- Zamanlu M, Farhoudi M, Eskandani M, Mahmoudi J, Barar J, Rafi M, Omidi Y. Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting. 2018;26(2):95 [Crossref]
31- Zhang Y, Zhang Y, Yin L, Xia X, Hu F, Liu Q, Qin C, Lan X. Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging. Contrast Media & Molecular Imaging. 2017;2017:1 [Crossref]
32- Ashique S, Anand K. Radiolabelled Extracellular Vesicles as Imaging Modalities for Precise Targeted Drug Delivery. Pharmaceutics. 2023;15(5):1426 [Crossref]
33- Fakhari A, Aghanejad A, Jalilian A, Gharepapagh E. Recent developments in targeted imaging of CXCR4-chemokine receptor. J Radioanal Nucl Chem. 2018;317(1):1 [Crossref]
34- Lu Z, Zongjie G, Qianyu Z, Xueyan L, Kexin W, Baoyan C, Ran T, Fang R, Hui H, Huali C. Preparation and characterization of a gemini surfactant-based biomimetic complex for gene delivery. European Journal of Pharmaceutics and Biopharmaceutics. 2023;182:92 [Crossref]
35- Radović M, Mirković M, Nikolić A, Kuraica M, Iskrenović P, Milanović Z, Vranješ-Đurić S, Perić M. Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles. J Inorg Organomet Polym. 2021;31(11):4426 [Crossref]
36- Drude N, Tienken L, Mottaghy F. Theranostic and nanotheranostic probes in nuclear medicine. Methods. 2017;130:14 [Crossref]
37- Saha Ray A, Ghann W, Tsoi P, Szychowski B, Dockery L, Pak Y, Li W, Kane M, Swaan P, Daniel M. Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form. Langmuir. 2019;35(9):3391 [Crossref]
38- Aghanejad A, Babamiri H, Adibkia K, Barar J, Omidi Y. Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells. BI. 2018;8(2):117 [Crossref]
39- Frantellizzi V, Verrina V, Raso C, Pontico M, Petronella F, Bertana V, Ballesio A, Marasso S, Miglietta S, Rosa P, Scibetta S, Petrozza V, De Feo M, De Vincentis G, Calogero A, Pani R, Perotto G, De Sio L. 99mTc-labeled keratin gold-nanoparticles in a nephron-like microfluidic chip for photo-thermal therapy applications. Materials Today Advances. 2022;16:100286 [Crossref]
40- Dolatkhah M, Hashemzadeh N, Barar J, Adibkia K, Aghanejad A, Barzegar-Jalali M, Omidian H, Omidi Y. Stimuli-responsive graphene oxide and methotrexate-loaded magnetic nanoparticles for breast cancer-targeted therapy. Nanomedicine. 2021;16(24):2155 [Crossref]
41- Dolatkhah M, Hashemzadeh N, Barar J, Adibkia K, Aghanejad A, Barzegar-Jalali M, Omidi Y. Graphene-based multifunctional nanosystems for simultaneous detection and treatment of breast cancer. Colloids and Surfaces B: Biointerfaces. 2020;193:111104 [Crossref]
42- Akbarzadeh Khiavi M, Safary A, Aghanejad A, Barar J, Rasta S, Golchin A, Omidi Y, Somi M. Enzyme-conjugated gold nanoparticles for combined enzyme and photothermal therapy of colon cancer cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019;572:333 [Crossref]
43- Chakravarty R, Chakraborty S, Guleria A, Shukla R, Kumar C, Vimalnath Nair K, Sarma H, Tyagi A, Dash A. Facile One-Pot Synthesis of Intrinsically Radiolabeled and Cyclic RGD Conjugated 199Au Nanoparticles for Potential Use in Nanoscale Brachytherapy. Ind Eng Chem Res. 2018;57(43):14337 [Crossref]
44- SARCAN E. NANOPARTICLES FOR DUAL IMAGING: PET AND FLUORESCENCE IMAGING. Ankara Ecz Fak Derg. 2024;48(2):3 [Crossref]
45- Sztandera K, Gorzkiewicz M, Klajnert-Maculewicz B. Gold Nanoparticles in Cancer Treatment. Mol Pharmaceutics. 2019;16(1):1 [Crossref]
46- Ranjbar Bahadori S, Mulgaonkar A, Hart R, Wu C, Zhang D, Pillai A, Hao Y, Sun X. Radiolabeling strategies and pharmacokinetic studies for metal based nanotheranostics. WIREs Nanomed Nanobiotechnol. 2021;13(2) [Crossref]
47- Apostolopoulou A, Chiotellis A, Salvanou E, Makrypidi K, Tsoukalas C, Kapiris F, Paravatou-Petsotas M, Papadopoulos M, Pirmettis I, Koźmiński P, Bouziotis P. Synthesis and In Vitro Evaluation of Gold Nanoparticles Functionalized with Thiol Ligands for Robust Radiolabeling with 99mTc. Nanomaterials. 2021;11(9):2406 [Crossref]
48- Liu M, Anderson R, Lan X, Conti P, Chen K. Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer. Medicinal Research Reviews. 2020;40(3):909 [Crossref]
49- Vandghanooni S, Eskandani M, Barar J, Omidi Y. Recent advances in aptamer-armed multimodal theranostic nanosystems for imaging and targeted therapy of cancer. European Journal of Pharmaceutical Sciences. 2018;117:301 [Crossref]
50- Kamelnia E, Divsalar A, Darroudi M, Yaghmaei P, Sadri K. Production of new cellulose nanocrystals from Ferula gummosa and their use in medical applications via investigation of their biodistribution. Industrial Crops and Products. 2019;139:111538 [Crossref]
51- Arif W, Elsinga P, Gasca-Salas C, Versluis M, Martínez-Fernández R, Dierckx R, Borra R, Luurtsema G. Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography. Journal of Controlled Release. 2020;324:303 [Crossref]
52- Ranjbar-Navazi Z, Eskandani M, Johari-Ahar M, Nemati A, Akbari H, Davaran S, Omidi Y. Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy. Journal of Drug Targeting. 2018;26(3):267 [Crossref]
53- Liolios C, Koutsikou T, Salvanou E, Kapiris F, Machairas E, Stampolaki M, Kolocouris A, Efthimiadou E, Bouziotis P. Synthesis and in vitro proof-of-concept studies on bispecific iron oxide magnetic nanoparticles targeting PSMA and GRP receptors for PET/MR imaging of prostate cancer. International Journal of Pharmaceutics. 2022;624:122008 [Crossref]
54- Xu H, Jiang S, Wang J, Li X, Wu T, Xu P, Santos-Oliveira R, Zhang A. Radioactive Gold Nanoparticle in Two Forms (19879Au GNPs and 99mTc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept. ACAMC. 2020;20(14):1648 [Crossref]
55- Salvanou E, Kolokithas-Ntoukas A, Liolios C, Xanthopoulos S, Paravatou-Petsotas M, Tsoukalas C, Avgoustakis K, Bouziotis P. Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents. Nanomaterials. 2022;12(14):2490 [Crossref]
56- Tong J, Hou X, Liu S, Zhang J, Ding Y, Wang Y, Xu H, Liu B. One‐Step Synthesis of Dicyanobenzene‐Derived Nitrogen‐Doped Porous Carbon Monolayers: Porosity and Near‐infrared Photoactivity. ChemCatChem. 2017;9(21):4043 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge