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Bioimpacts. 2018;8(3): 201-209. doi: 10.15171/bi.2018.23
PMID: 30211080        PMCID: PMC6128976

Original Research

In silico identification of albendazole as a quorum sensing inhibitor and its in vitro verification using CviR and LasB receptors based assay systems

Shaminder Singh 1,2 * , Sonam Bhatia 3

Cited by CrossRef: 13

1- Mohan A, Rajan P, Kumar P, Jayakumar D, Mini M, Asha S, Vaikkathillam P. Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum. Int Microbiol. 2024;27(5):1457 [Crossref]
2- Mishra P, Banga I, Tyagi R, Munjal T, Goel A, Capalash N, Sharma P, Suri C, Gandhi S. An immunochromatographic dipstick as an alternate for monitoring of heroin metabolites in urine samples. RSC Adv. 2018;8(41):23163 [Crossref]
3- Khatoon N, Alam Z, Hussain I, Khubaib B, Javed M, Ali Q. Comprehensive analysis of Seriphidium kurramense: GC/MS profiling, antibacterial and antibiofilm activities, molecular docking study and in-silico ADME profiling. Discov Appl Sci. 2024;6(3) [Crossref]
4- Patel P, Joshi C, Kothari V. Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria. Advances in Pharmacological Sciences. 2019;2019:1 [Crossref]
5- Peng B, Li Y, Yin J, Ding W, Fazuo W, Xiao Z, Yin H. A bibliometric analysis on discovering anti-quorum sensing agents against clinically relevant pathogens: current status, development, and future directions. Front Microbiol. 2023;14 [Crossref]
6- Paswan U, Basak H, Saha S, Chatterjee A. In Silico Screening of FDA‐Approved Anthelmintic Drugs Against LuxR Protein as Quorum‐Sensing Inhibitors and Exploration of Their Binding Mechanism and Electronics Properties. ChemistrySelect. 2024;9(40) [Crossref]
7- Vetrivel A, Ramasamy M, Vetrivel P, Natchimuthu S, Arunachalam S, Kim G, Murugesan R. Pseudomonas aeruginosa Biofilm Formation and Its Control. Biologics. 2021;1(3):312 [Crossref]
8- Subash P, Uma A, Ahilan B, Kannan S. In vivo and in silico investigations on the efficacy of albendazole against Enterocytozoon hepatopenaei (EHP) infecting Penaeus vannamei. Aquaculture. 2023;575:739801 [Crossref]
9- Murali M, Ahmed F, Gowtham H, Aribisala J, Abdulsalam R, Shati A, Alfaifi M, Sayyed R, Sabiu S, Amruthesh K. Exploration of CviR-mediated quorum sensing inhibitors from Cladosporium spp. against Chromobacterium violaceum through computational studies. Sci Rep. 2023;13(1) [Crossref]
10- Zhou L, Zhang Y, Ge Y, Zhu X, Pan J. Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation. Front Microbiol. 2020;11 [Crossref]
11- Wang J, Lu X, Wang C, Yue Y, Wei B, Zhang H, Wang H, Chen J. Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance. Molecules. 2024;29(7):1674 [Crossref]
12- Hambal M, Frengki F, Sari W, Vanda H. In silico prediction of flavan-3-ol as a bioactive compound of Calophyllum macrophyllum as a potential drug against angiostrongylus eosinophilic meningitis. Vet World. 2022;:1305 [Crossref]
13- Martins F, Melo A, Sousa S. Identification of New Potential Inhibitors of Quorum Sensing through a Specialized Multi-Level Computational Approach. Molecules. 2021;26(9):2600 [Crossref]
14- Baloyi I, Adeosun I, Yusuf A, Cosa S. In Silico and In Vitro Screening of Antipathogenic Properties of Melianthus comosus (Vahl) against Pseudomonas aeruginosa. Antibiotics. 2021;10(6):679 [Crossref]
15- Wu S, Yang S, Wang M, Song N, Feng J, Wu H, Yang A, Liu C, Li Y, Guo F, Qiao J. Quorum sensing-based interactions among drugs, microbes, and diseases. Sci China Life Sci. 2023;66(1):137 [Crossref]
16- Chadha J, Khullar L, Gulati P, Chhibber S, Harjai K. Repurposing albendazole as a potent inhibitor of quorum sensing-regulated virulence factors in Pseudomonas aeruginosa: Novel prospects of a classical drug. Microbial Pathogenesis. 2024;186:106468 [Crossref]
17- Lal A, Singh S, Franco F, Bhatia S. Potential of polyphenols in curbing quorum sensing and biofilm formation in Gram-negative pathogens. 2021;11(6):231 [Crossref]
18- Khan F, Pham D, Oloketuyi S, Kim Y. Antibiotics Application Strategies to Control Biofilm Formation in Pathogenic Bacteria. CPB. 2020;21(4):270 [Crossref]
19- Canturri A, Smani Y. Anthelmintic Drugs for Repurposing against Gram-Negative Bacilli Infections. CMC. 2023;30(1):59 [Crossref]
20- Ghosh M, Raghav S, Ghosh P, Maity S, Mohela K, Jain D. Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms. 2023;47(5) [Crossref]
21- Roberts A, Tripathi P, Gandhi S. Graphene nanosheets as an electric mediator for ultrafast sensing of urokinase plasminogen activator receptor-A biomarker of cancer. Biosensors and Bioelectronics. 2019;141:111398 [Crossref]
22- Parastan R, Kargar M, Solhjoo K, Kafilzadeh F. Staphylococcus aureus biofilms: Structures, antibiotic resistance, inhibition, and vaccines. Gene Reports. 2020;20:100739 [Crossref]
23- Hetta H, Ramadan Y, Rashed Z, Alharbi A, Alsharef S, Alkindy T, Alkhamali A, Albalawi A, Battah B, Donadu M. Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria. Molecules. 2024;29(15):3466 [Crossref]
24- Revanasiddappa P, H. G. G, K. P. C, Natarajamurthy S, K. N, Pradeep S, Shivamallu C, Elossaily G, Achar R, Silina E, Stupin V, Manturova N, A. Shati A, Y. Alfaifi M, I. Elbehairi S, Kestur Nagaraj A, Mahadevamurthy M, Kollur S. Computational exploration of Picrasma quassioides compounds as CviR-mediated quorum sensing inhibitors against Chromobacterium violaceum. Front Chem. 2024;12 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
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