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Bioimpacts. 2018;8(4): 241-252. doi: 10.15171/bi.2018.27
PMID: 30397579        PMCID: PMC6209830

Original Research

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

Maryam Monajati 1,2, Shirin Tavakoli 3, Samira Sadat Abolmaali 4, Gholamhossein Yousefi 4, AliMohammad Tamaddon 3 *

Cited by CrossRef: 21

1- Wang L, Chen M, Ran X, Tang H, Cao D. Sorafenib-Based Drug Delivery Systems: Applications and Perspectives. Polymers. 2023;15(12):2638 [Crossref]
2- Ghosh R, Dey J. pH-Responsive Vesicle Formation by PEGylated Cholesterol Derivatives: Physicochemical Characterization, Stability, Encapsulation, and Release Study. Langmuir. 2020;36(21):5829 [Crossref]
3- Mahmoud K, Swidan S, El-Nabarawi M, Teaima M. Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances. J Nanobiotechnol. 2022;20(1) [Crossref]
4- Misiak P, Markiewicz K, Szymczuk D, Wilczewska A. Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review. Polymers. 2020;12(11):2620 [Crossref]
5- Behzadnia M, Salmanpour M, Heidari M, Monajati M, Farjadian F, Abedi M, Tamaddon A. Sorafenib tosylate incorporation into mesoporous starch xerogel for in-situ micronization and oral bioavailability enhancement. Drug Development and Industrial Pharmacy. 2022;48(8):343 [Crossref]
6- Roustazadeh A, Askari M, Heidari M, Kowsari M, Askari F, Mehrzad J, Hosseinkhani S, Alipour M, Bardania H. Enhancing non-viral gene delivery to human T cells through tuning nanoparticles physicochemical features, modulation cellular physiology, and refining transfection strategies. Biomedicine & Pharmacotherapy. 2025;183:117820 [Crossref]
7- Abd Elhameed H, Ungor D, Igaz N, Gopisetty M, Kiricsi M, Csapó E, Gyurcsik B. High Molecular Weight Poly(ethylenimine)‐Based Water‐Soluble Lipopolymer for Transfection of Cancer Cells. Macromolecular Bioscience. 2020;20(7) [Crossref]
8- Pradhan A, Biswal S, Bhal S, Biswal B, Kundu C, Subuddhi U, Pati A, Hassan P, Patel S. Amphiphilic Poly(ethylene glycol)-Cholesterol Conjugate: Stable Micellar Formulation for Efficient Loading and Effective Intracellular Delivery of Curcumin. ACS Appl Bio Mater. 2025;8(2):1418 [Crossref]
9- Yao L, Li H, Tu K, Zhang L, Cheng Z, Zhu X. Construction of NIR Light Controlled Micelles with Photothermal Conversion Property: Poly(poly(ethylene glycol)methyl ether methacrylate) (PPEGMA) as Hydrophilic Block and Ketocyanine Dye as NIR Photothermal Conversion Agent. Polymers. 2020;12(5):1181 [Crossref]
10- Nasr M, Saber S, Elagamy H, El-Masry S, Asad H, Mourad A, Gaafar A, Mostafa S. Sorafenib nanocrystals enhance bioavailability and overcome multidrug resistance in liver cancer cells: an approach based on P-gp inhibition strategy. Mater Adv. 2025;6(10):3104 [Crossref]
11- Tiburcius S, Krishnan K, Yang J, Hashemi F, Singh G, Radhakrishnan D, Trinh H, Verrills N, Karakoti A, Vinu A. Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment. The Chemical Record. 2021;21(6):1535 [Crossref]
12- Shukla S, Goyal M, Kanabar D, Ayehunie S, Deore B, Sanhueza C, Muth A, Gupta V. Exploring the enhanced stability and therapeutic efficacy of Sorafenib-Cyclodextrin inclusion complex. Journal of Molecular Liquids. 2024;401:124701 [Crossref]
13- Feng X, Liu F, Chen W, Du J, Liu H. Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy. World J Gastrointest Oncol. 2023;15(4):617 [Crossref]
14- Zhao M, Hao D, Wu Q, Li Y, Pei Q, Sun T, Wang K, Xie Z. Porphyrin Cholesterol Conjugates for Enhanced Photodynamic Immunotherapy toward Lung Cancer. ACS Appl Mater Interfaces. 2023;15(30):35927 [Crossref]
15- Wang Z, Liu J, Zhou Z, Yu J, Hao L, Hu S, Lu Z, Wang L, Ding Y. Cell Membrane-Coated Hollow Manganese Dioxide Drug Delivery Nanosystem for Targeted Liver Cancer Diagnosis and Treatment. ACS Appl Nano Mater. 2024;7(16):18262 [Crossref]
16- Hwang C, Lee J, Kim D, Na K, Kim D. Real-Time and Highly Sensitive Detection of Matrix Metalloproteinase 9 (MMP-9) in Tears Using Aptamer Functionalized Electrolyte-Gated IGZO Thin-Film Transistors. ACS Appl Mater Interfaces. 2025; [Crossref]
17- Kibar G, Dutta S, Rege K, Usta O. Evaluation of drug carrier hepatotoxicity using primary cell culture models. Nanomedicine: Nanotechnology, Biology and Medicine. 2023;48:102651 [Crossref]
18- Razmimanesh F, Sodeifian G. Evaluation of a temperature-responsive magnetotocosome as a magnetic targeting drug delivery system for sorafenib tosylate anticancer drug. Heliyon. 2023;9(11):e21794 [Crossref]
19- Maboudi A, Lotfipour M, Rasouli M, Azhdari M, MacLoughlin R, Bekeschus S, Doroudian M. Micelle-based nanoparticles with stimuli-responsive properties for drug delivery. 2024;13(1) [Crossref]
20- Monajati M, Tamaddon A, Abolmaali S, Yousefi G, Jafari M, Heidari R, Borandeh S, Azarpira N, Dinarvand R. Novel self-assembled nanogels of PEG-grafted poly HPMA with bis(α-cyclodextrin) containing disulfide linkage: synthesis, bio-disintegration, and in vivo biocompatibility. New J Chem. 2022;46(20):9931 [Crossref]
21- Jafari M, Abolmaali S, Borandeh S, Najafi H, Zareshahrabadi Z, Heidari R, Azarpira N, Zomorodian K, Tamaddon A. Amphiphilic hyperbranched polyglycerol nanoarchitectures for Amphotericin B delivery in Candida infections. Biomaterials Advances. 2022;139:212996 [Crossref]
22- Fang Z, Wang X, Sun Y, Fan R, Liu Z, Guo R, Xie D. Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia. Nanoscale. 2019;11(47):23000 [Crossref]
23- Abbasi S, Yousefi G, Tamaddon A, Firuzi O. Paclitaxel‐loaded polypeptide‐polyacrylamide nanomicelles overcome drug‐resistance by enhancing lysosomal membrane permeability and inducing apoptosis. J Biomedical Materials Res. 2021;109(1):18 [Crossref]
24- Kiani M, ul Hassan M, Hussain S, Kiani Z, Ibrahim I, Shahnaz G, Rahdar A, Díez-Pascual A. Cholesterol decorated thiolated stereocomplexed nanomicelles for improved anti-mycobacterial potential via efflux pump and mycothione reductase inhibition. Journal of Molecular Liquids. 2022;367:120378 [Crossref]
25- Le-Deygen I, Skuredina A, Bui V, Tran M, Pham T. Smart Delivery Systems of Sorafenib Based on Biopolymers and Supramolecular Assemblies. Russ J Bioorg Chem. 2025;51(3):1011 [Crossref]
26- Eusébio D, Paul M, Biswas S, Cui Z, Costa D, Sousa Â. Mannosylated polyethylenimine-cholesterol-based nanoparticles for targeted delivery of minicircle DNA vaccine against COVID-19 to antigen-presenting cells. International Journal of Pharmaceutics. 2024;654:123959 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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