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Bioimpacts. 2018;8(4): 305-320. doi: 10.15171/bi.2018.33
PMID: 30397585        PMCID: PMC6209825

Review

Recent advances in improving oral drug bioavailability by cocrystals

Shahram Emami 1,2, Mohammadreza Siahi-Shadbad 3, Khosro Adibkia 4 ORCID, Mohammad Barzegar-Jalali 5 *

Cited by CrossRef: 92

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17- Allu S, An J, Park B, Kim W. Solubility Enhancement of the Nonsteroidal Anti-inflammatory Drug of Pelubiprofen Salts. Crystal Growth & Design. 2023;23(10):7231 [Crossref]
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19- Mendis N, Lakerveld R. An In Vitro Model for Cocrystal Dissolution with Simultaneous Surface and Bulk Precipitation. Mol Pharmaceutics. 2023;20(11):5486 [Crossref]
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29- Huang S, Dong R, Xu G, Liu J, Gao X, Yu S, Qie P, Gou G, Hu M, Wang Y, Peng J, Guang B, Xu Y, Yang T. Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats. ACS Omega. 2020;5(9):4595 [Crossref]
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31- Ye T, Tang D, Tao C, Chen X, Wang X, Xie Y. Absorption enhancement of peach kernel oil on hydroxysafflor yellow A in safflower extracts and its mechanisms. Food Chemistry. 2024;458:140218 [Crossref]
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34- Gołdyn M, Larowska D, Bartoszak-Adamska E. Novel Purine Alkaloid Cocrystals with Trimesic and Hemimellitic Acids as Coformers: Synthetic Approach and Supramolecular Analysis. Crystal Growth & Design. 2021;21(1):396 [Crossref]
35- Eesam S, Bhandaru J, Naliganti C, Bobbala R, Akkinepally R. Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide. Futur J Pharm Sci. 2020;6(1) [Crossref]
36- Meng Y, Tan F, Yao J, Cui Y, Feng Y, Li Z, Wang Y, Yang Y, Gong W, Yang M, Kong X, Gao C. Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs. International Journal of Pharmaceutics: X. 2022;4:100119 [Crossref]
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39- A, I, N, S. Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients. AJPS. 2023;23(2):180 [Crossref]
40- Nugrahani I, Fisandra F, Horikawa A, Uekusa H. New Sodium Mefenamate – Nicotinamide Multicomponent Crystal Development to Modulate Solubility and Dissolution: Preparation, Structural, and Performance Study. Journal of Pharmaceutical Sciences. 2021;110(9):3246 [Crossref]
41- Pantwalawalkar J, Kale N, Nangare S, Patil S, Pawar S, Jadhav N. Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates. Journal of Drug Delivery Science and Technology. 2025;104:106572 [Crossref]
42- Soumya K, More N, Choppadandi M, Aishwarya D, Singh G, Kapusetti G. A comprehensive review on carbon quantum dots as an effective photosensitizer and drug delivery system for cancer treatment. Biomedical Technology. 2023;4:11 [Crossref]
43- Emami S, Shayanfar A. Deep eutectic solvents for pharmaceutical formulation and drug delivery applications. Pharmaceutical Development and Technology. 2020;25(7):779 [Crossref]
44- Wang L, Yan Y, Zhang X, Zhou X. Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study. International Journal of Pharmaceutics. 2022;613:121394 [Crossref]
45- Lin B, Liu Y, Wang M, Wang Y, Du S, Gong J, Wu S. Intermolecular Interactions and Solubility Behavior of Multicomponent Crystal Forms of Orotic Acid: Prediction and Experiments. Crystal Growth & Design. 2021;21(3):1473 [Crossref]
46- Rana M, Garai A, Nangia A. Cocrystals and Salts of Milrinone with Fluoro Coformers: Improving Drug Dissolution and Diffusion and Calculating Normalized Diffusion for Pharmaceutical Cocrystals. Crystal Growth & Design. 2023;23(9):6461 [Crossref]
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51- Jiang X, Yu K, Nam D, Oh J. A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects. Pharmaceuticals. 2024;17(4):522 [Crossref]
52- Batool R, Mudassir J, Khan M, Zafar S, Rana S, Abbas N, Hussain A, Arshad M, Muhammad S. Fabrication and Characterization of Celecoxib-Loaded Chitosan/Guar Gum-Based Hydrogel Beads. Pharmaceuticals. 2023;16(4):554 [Crossref]
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55- Elshahat A, Hasan A, Elghamry H, Balata G. Formulation and optimization of olanzapine-carboxylic acid cocrystals orodispersible tablets: In-vitro/ In-vivo study. Journal of Drug Delivery Science and Technology. 2024;100:106093 [Crossref]
56- Nugrahani I, Tjengal B, Gusdinar T, Horikawa A, Uekusa H. A Comprehensive Study of a New 1.75 Hydrate of Ciprofloxacin Salicylate: SCXRD Structure Determination, Solid Characterization, Water Stability, Solubility, and Dissolution Study. Crystals. 2020;10(5):349 [Crossref]
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58- Parkes A, Ziaee A, O'Reilly E. Evaluating experimental, knowledge-based and computational cocrystal screening methods to advance drug-drug cocrystal fixed-dose combination development. European Journal of Pharmaceutical Sciences. 2024;203:106931 [Crossref]
59- Chhatbar M, Borkhataria C, Patel O, Raichura K, Pethani T, Parmar G, Mori D, Manek R. Enhancing the solubility and bioavailability of itraconazole through pharmaceutical cocrystallization: A promising strategy for drug formulation. Journal of Pharmaceutical Sciences. 2025;114(6):103770 [Crossref]
60- Zhang Q, Chan D, Ho K. Efficacy and Safety of Fixed-Dose Combinations for Pain in Older Adults. Drugs Aging. 2024;41(11):873 [Crossref]
61- Yu Y, Bu F, Meng S, Yan C, Wu Z, Li Y. The first marine dual-drug cocrystal of cytarabine with 5-fluorouracil having synergistic antitumor effects shows superior biopharmaceutical peculiarities by oral administration. International Journal of Pharmaceutics. 2022;629:122386 [Crossref]
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70- Przybyłek M, Jeliński T, Słabuszewska J, Ziółkowska D, Mroczyńska K, Cysewski P. Application of Multivariate Adaptive Regression Splines (MARSplines) Methodology for Screening of Dicarboxylic Acid Cocrystal Using 1D and 2D Molecular Descriptors. Crystal Growth & Design. 2019;19(7):3876 [Crossref]
71- Latif S, Ijaz Q, Hameed M, Shoaib Q, Fatima K, Hussain A, Arshad M, Abbas N. Improvement of Physico-mechanical and pharmacokinetic attributes of naproxen by cocrystallization with l-alanine. Journal of Drug Delivery Science and Technology. 2021;61:102236 [Crossref]
72- Palamidi A, Kapourani A, Christodoulou E, Klonos P, Kontogiannopoulos K, Kyritsis A, Bikiaris D, Barmpalexis P. Low Molecular Weight Oligomers of Poly(alkylene succinate) Polyesters as Plasticizers in Poly(vinyl alcohol) Based Pharmaceutical Applications. Polymers. 2021;13(1):146 [Crossref]
73- Samie A, Alavian H. A Perspective on the Permeability of Cocrystals/Organic Salts of Oral Drugs. Mol Pharmaceutics. 2024;21(10):4860 [Crossref]
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