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Bioimpacts. 2019;9(4): 239-249. doi: 10.15171/bi.2019.29
PMID: 31799160        PMCID: PMC6879709

Original Research

In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Gnetum ula Brongn

Preetham Jinadatta 1 * , Sharath Rajshekarappa 2, Kiran Sundera Raja Rao 1, Sujan Ganapathy Pasura Subbaiah 3, Sudhesh Shastri 4

Cited by CrossRef: 11

1- Al‐Shuhaib M, Al‐Shuhaib J. Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments. Chemistry & Biodiversity. 2025;22(1) [Crossref]
2- Sahoo S, Rath D, Kar D, Pattanaik S. Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells. Journal of Ethnopharmacology. 2023;304:116076 [Crossref]
3- D R, AG T, S S, M K, Kumar Sharma G, CL M, Kumar D. Quercetin Nanoparticles as a Promising Intervention against Ethion‐Induced Hepatic Damage in Wistar Albino Rats.. ChemistrySelect. 2024;9(23) [Crossref]
4- Fraga H, Moraes P, Vieira L, Guerra M. Somatic Embryogenesis in Conifers: One Clade to Rule Them All?. Plants. 2023;12(14):2648 [Crossref]
5- Huong N, Hop N, Duy D, Son N. The genus Gnetum: Traditional use, phytochemistry, nutritional value, biosynthesis, synthesis, pharmacology, toxicology, synthetic advance, and pharmacokinetics. Fitoterapia. 2025;182:106461 [Crossref]
6- Bagchi A, Raha A, Das C, Dash P, Pradhan D, Rai V, Rajwar T, Halder J, Das D, Manoharadas S, Kar B, Ghosh G, Rath G. Hepatoprotective efficacy of Argemone mexicana L. root in paracetamol-induced hepatotoxicity in a rat model. Journal of Ethnopharmacology. 2025;341:119329 [Crossref]
7- Iqbal N, Zubair H, Almutairi M, Abbas M, Akhtar M, Aleya L, Kamel M, Saleem A, Jabeen Q, Noreen S, Baig M, Abdel-Daim M. Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2–NFκB pathways. Biomedicine & Pharmacotherapy. 2022;156:113840 [Crossref]
8- Pundalik S, Hanumappa K, Giresha A, Urs D, Rajashekarappa S, Muniyappa N, Jamballi G M, Kuaramkote Shivanna D, S Meti R, Anekere Dasappa Setty S, Thippegowda P, Krishnappa D. Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice. JIR. 2022;Volume 15:6905 [Crossref]
9- Ranjith D, Telang A, Subhadra S, Kamothi D, Madhu C, Kumar D. Chitosan-TPP encapsulated quercetin nanoparticles: amplified protection mechanisms unveiled against Ethion-induced developmental toxicity through comprehensive in-vivo and in-silico elucidation. 2024;13(3) [Crossref]
10- Vinaykumar N, Mahmood R, Krishna V, Ravishankara B, Shastri S. Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract. Clin Phytosci. 2020;6(1) [Crossref]
11- Navarro‐Orcajada S, Conesa I, Matencio A, García‐Carmona F, López‐Nicolás J. Molecular encapsulation and bioactivity of gnetol, a resveratrol analogue, for use in foods. J Sci Food Agric. 2022;102(10):4296 [Crossref]
12- Rao Rao Shimoga Janakirama A, Mathad Shivayogi S, Kolkar Satyanarayana J, Chapeyil Kumaran R. Characterization of isolated compounds from Morus spp. and their biological activity as anticancer molecules. Bioimpacts. 2020;11(3):187 [Crossref]
13- Giresha A, Urs D, Pundalik S, Meti R, Pramod S, Supreetha B, Somegowda M, Dharmappa K, El-Shehawi A, Albogami S, Elseehy M, Alaklabi A, Elansary H, Mehder A, Mahmoud E. Sinapicacid Inhibits Group IIA Secretory Phospholipase A2 and Its Inflammatory Response in Mice. Antioxidants. 2022;11(7):1251 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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