Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages

Reddy Amala ¹, Sundaresan Sujatha ¹ *

Cited by CrossRef: 10

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2- Padmanabhan D, Manimekalai R, Senthil-Nathan S, Suganthi M, Palanisamy S. Biosynthesis, therapeutic characteristics, origin and strategies to improve the yield of vasicine in plants. Vegetos. 2025; [Crossref]

3- Wenger N, Qiao L, Nicola T, Nizami Z, Xu X, Willis K, Ambalavanan N, Gaggar A, Lal C. Efficacy of a Probiotic and Herbal Supplement in Models of Lung Inflammation. Microorganisms. 2022;10(11):2136 [Crossref]

4- Wenger N, Qiao L, Nicola T, Nizami Z, Martin I, Halloran B, Tanaka K, Evans M, Xu X, Dinan T, Kakilla C, DunnGalvin G, Ambalavanan N, Willis K, Gaggar A, Lal C. Clinical trial of a probiotic and herbal supplement for lung health. Front Nutr. 2023;10 [Crossref]

5- Eapen A, Pillai A, Roy S. Unveiling the Potential, Biological Properties and Application of Adhatoda vasica: A Review. Curr Food Sci Tech Rep. 2024;3(1) [Crossref]

6- Ghanta P, Doble M, Ramaiah B. Alkaloids of Adhatoda vasica Nees. as potential inhibitors of cyclooxygenases – an in-silico study. Journal of Biomolecular Structure and Dynamics. 2022;40(16):7245 [Crossref]

7- Afrin S, Islam M, Kondaveeti S, Batra H, Azmee R, Azmee M, Jakir F, Jamali M, Al-Aouadi R, Wei C, Syrmos N, Mahedi R, Shohag A. A Narrative Review on Morphological Description, Ethnomedicinal Usage, Phytochemical Constituents and Pharmacological Activities: Microcos paniculata. RJPT. 2025;:1419 [Crossref]

8- Dhane R, Shinde R. Herbal Remedies in Post-COVID Trauma: A Systematic Review. Biosci, Biotech Res Asia. 2022;19(4):875 [Crossref]

9- Khandelwal P, Wadhwani B, Rao R, Mali D, Vyas P, Kumar T, Nair R. Exploring the pharmacological and chemical aspects of pyrrolo-quinazoline derivatives in Adhatoda vasica. Heliyon. 2024;10(4):e25727 [Crossref]

10- Bhaskar D, Tahira H. The Potential Pharmacological Mechanism of Medicinal Herbs for the Treatment of Cough and Cold via Network Pharmacology, Molecular Docking and Simulation. EJMED. 2025;7(6):13 [Crossref]

11- Subramanian M, Selvaraj K, Jagannathan R, Rajendran S, Rajendran D, Madapusi B. Potential Uses of Adhatoda Vasica in Orthodontics. 2023;15(Suppl 1):S40 [Crossref]

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