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Bioimpacts. 2020;10(2): 87-95. doi: 10.34172/bi.2020.11
PMID: 32363152        PMCID: PMC7186544

Original Research

Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin

Ashkan Hassankhani Rad 1,2 ORCID, Farshid Asiaee 1,2 ORCID, Sevda Jafari 2,3 ORCID, Ali Shayanfar 2 ORCID, Afsaneh Lavasanifar 4 ORCID, Ommoleila Molavi 3,5,2 * ORCID

Cited by CrossRef: 11

1- Chatterjee D, Bhattacharya S, Kumari L, Datta A. Aptamers: ushering in new hopes in targeted glioblastoma therapy. Journal of Drug Targeting. 2024;32(9):1005 [Crossref]
2- Bhattacharjee S, Brayden D. Addressing the challenges to increase the efficiency of translating nanomedicine formulations to patients. Expert Opinion on Drug Discovery. 2021;16(3):235 [Crossref]
3- Saadat M, Jafari S, Mahmoudian M, Sarfraz M, Khaleseh F, Zakeri-Milani P, Shahbazi-Mojarrad J, Valizadeh H. Choline Based Surfactants Promote Cellular Uptake of Solid Lipid Nanoparticles into Lung and Breast Cancer Cells. CNANO. 2025;21(4):702 [Crossref]
4- Wu W, Wang L, Wang S. Amorphous silibinin nanoparticles loaded into porous starch to enhance remarkably its solubility and bioavailability in vivo. Colloids and Surfaces B: Biointerfaces. 2021;198:111474 [Crossref]
5- Veselov V, Nosyrev A, Jicsinszky L, Alyautdin R, Cravotto G. Targeted Delivery Methods for Anticancer Drugs. Cancers. 2022;14(3):622 [Crossref]
6- Gileva A, Kulikova D, Kukovyakina E, Yagolovich A, Kushnerev K, Kuskov A, Markvicheva E. Cytotoxicity of curcumin-loaded nanoparticles based on amphiphilic poly-N-vinylpyrrolidone derivatives in 2D and 3D in vitro models of human ovarian adenocarcinoma. Russian Journal of Oncology. 2024;29(3):171 [Crossref]
7- Jafari S, Heydarian S, Lai R, Mehdizadeh Aghdam E, Molavi O. Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy. Bioimpacts. 2023;13(1):51 [Crossref]
8- Saraei M, Sarvari R, Fakhri E, Fariyan S. Antibacterial polymeric micelles based on kojic acid/acrylic acid/chitosan. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024;73(2):131 [Crossref]
9- Khazei K, Mohajeri N, Bonabi E, Turk Z, Zarghami N. New Insights Toward Nanostructured Drug Delivery of Plant-Derived Polyphenol Compounds: Cancer Treatment and Gene Expression Profiles. CCDT. 2021;21(8):689 [Crossref]
10- Dabbaghi A, Ramazani A, Farshchi N, Rezaei A, Bodaghi A, Rezayati S. Synthesis, physical and mechanical properties of amphiphilic hydrogels based on polycaprolactone and polyethylene glycol for bioapplications: A review. Journal of Industrial and Engineering Chemistry. 2021;101:307 [Crossref]
11- Ansari M, Kulkarni Y, Singh K. Advanced Technologies of Drug Delivery to the Posterior Eye Segment Targeting Angiogenesis and Ocular Cancer. Crit Rev Ther Drug Carrier Syst. 2024;41(1):85 [Crossref]
12- Amiri M, Jafari S, Lavasanifar A, Molavi O, Montazersaheb S. Nano-delivery of Silibinin Potentiate the Induction of Immunogenic Cell Death (ICD) in Melanoma Cells. CPB. 2025;26(3):392 [Crossref]
13- Behl A, Solanki S, Paswan S, Datta T, Saini A, Saini R, Parmar V, Thakur V, Malhotra S, Chhillar A. Biodegradable PEG-PCL Nanoparticles for Co-delivery of MUC1 Inhibitor and Doxorubicin for the Confinement of Triple-Negative Breast Cancer. J Polym Environ. 2023;31(3):999 [Crossref]
14- Samuel H, Okibe G, Ilumunter M, David U, Omeche E, Mahmud F. Applications of Nanotechnology in Drug Delivery Systems. Baghdad J Biochem Appl Biol Sci. 2024;5(3):162 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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