Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period

Nadezhda V. Maksimova ¹ , Anna V. Michenko ², Olga A. Krasilnikova ³ , Ilya D. Klabukov ³ * , Igor Yu. Gadaev ⁴ , Michael E. Krasheninnikov ⁵ , Pavel A. Belkov ⁶, Aleksey V. Lyundup ⁵

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1- Brownell D, Chabaud S, Bolduc S. Tissue Engineering in Gynecology. IJMS. 2022;23(20):12319 [Crossref]

2- Guo Y, Song Y, Xiong S, Wang T, Liu W, Yu Z, Ma X. Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion. IJMS. 2022;23(17):9622 [Crossref]

3- Anjiki K, Matsumoto T, Kuroda Y, Fujita M, Hayashi S, Nakano N, Tsubosaka M, Kamenaga T, Takashima Y, Kikuchi K, Ikuta K, Onoi Y, Tachibana S, Suda Y, Wada K, Matsushita T, Kuroda R. Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis. Stem Cell Rev and Rep. 2023;19(7):2407 [Crossref]

4- Trivanovic D, Volkmann N, Stoeckl M, Tertel T, Rudert M, Giebel B, Herrmann M. Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming. Stem Cell Rev and Rep. 2023;19(3):713 [Crossref]

5- Krasilnikova O, Baranovskii D, Lyundup A, Shegay P, Kaprin A, Klabukov I. Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action. Stem Cell Rev and Rep. 2022;18(6):1974 [Crossref]

6- Klabukov I, Yatsenko E, Baranovskii D. The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing: ignoring the possibility of adverse events and side effects could compromise study results. Arch Dermatol Res. 2023;316(1) [Crossref]

7- Alfaro S, Acuña V, Ceriani R, Cavieres M, Weinstein-Oppenheimer C, Campos-Estrada C. Involvement of Inflammation and Its Resolution in Disease and Therapeutics. IJMS. 2022;23(18):10719 [Crossref]

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