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BioImpacts. 2021;11(1): 65-84. doi: 10.34172/bi.2021.11
PMID: 33469510        PMCID: PMC7803919

Original Research

A domain-based vaccine construct against SARS-CoV-2, the causative agent of COVID-19 pandemic: development of self-amplifying mRNA and peptide vaccines

Mohammad Mostafa Pourseif 1 ORCID, Sepideh Parvizpour 1, Behzad Jafari 2,1, Jaber Dehghani 1 ORCID, Behrouz Naghili 3, Yadollah Omidi 4 * ORCID

Cited by CrossRef: 29

1- Althurwi H, Alharthy K, Albaqami F, Altharawi A, Javed M, Muhseen Z, Tahir ul Qamar M. mRNA-Based Vaccine Designing against Epstein-Barr Virus to Induce an Immune Response Using Immunoinformatic and Molecular Modelling Approaches. IJERPH. 2022;19(20):13054 [Crossref]
2- Albaqami F, Altharawi A, Althurwi H, Alharthy K, Qasim M, Muhseen Z, Tahir ul Qamar M, Hassan S. Computational Modeling and Evaluation of Potential mRNA and Peptide‐Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever. BioMed Research International. 2023;2023(1) [Crossref]
3- Masoudi-Sobhanzadeh Y, Salemi A, Pourseif M, Jafari B, Omidi Y, Masoudi-Nejad A. Structure-based drug repurposing against COVID-19 and emerging infectious diseases: methods, resources and discoveries. 2021;22(6) [Crossref]
4- Aljindan R, Al-Subaie A, Al-Ohali A, Kumar D T, Doss C G, Kamaraj B. Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach. Computers in Biology and Medicine. 2021;135:104654 [Crossref]
5- Tahir ul Qamar M, Ahmad S, Fatima I, Ahmad F, Shahid F, Naz A, Abbasi S, Khan A, Mirza M, Ashfaq U, Chen L. Designing multi-epitope vaccine against Staphylococcus aureus by employing subtractive proteomics, reverse vaccinology and immuno-informatics approaches. Computers in Biology and Medicine. 2021;132:104389 [Crossref]
6- Dobhal S, Chauhan K, Kumar S, Shikha S, Jogi M, Kumar D, Kumar A, Jaiswal V, Kumar P. In silico Identification of MHC Displayed Tumor Associated Peptides in Ovarian Cancer for Multi-Epitope Vaccine Construct. EMIDDT. 2024;24(12):1401 [Crossref]
7- Dehghani J, Movafeghi A, Mathieu-Rivet E, Mati-Baouche N, Calbo S, Lerouge P, Bardor M. Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants. Marine Drugs. 2022;20(11):657 [Crossref]
8- Wadapurkar R, Singh S, Singh A. Leveraging the immunoinformatics approach for designing the SARS-CoV-2 omicron-specific antigenic cassette of mRNA vaccine. Vaccine. 2024;42(7):1630 [Crossref]
9- Speth R. An opinion on the impacts of COVID-19 worldwide. Bioimpacts. 2022;12(3):293 [Crossref]
10- Pourseif M, Masoudi-Sobhanzadeh Y, Azari E, Parvizpour S, Barar J, Ansari R, Omidi Y. Self-amplifying mRNA vaccines: Mode of action, design, development and optimization. Drug Discovery Today. 2022;27(11):103341 [Crossref]
11- Ahmadi M. Would the interference phenomenon be applied as an alternative option for prophylaxis against COVID-19?. Bioimpacts. 2020;11(3):169 [Crossref]
12- Moradi M, Golmohammadi R, Najafi A, Moosazadeh Moghaddam M, Fasihi-Ramandi M, Mirnejad R. A contemporary review on the important role of in silico approaches for managing different aspects of COVID-19 crisis. Informatics in Medicine Unlocked. 2022;28:100862 [Crossref]
13- Silva-Pilipich N, Beloki U, Salaberry L, Smerdou C. Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19. Vaccines. 2024;12(3):318 [Crossref]
14- Maison D, Ching L, Cleveland S, Tseng A, Nakano E, Shikuma C, Nerurkar V. Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccines. Commun Biol. 2022;5(1) [Crossref]
15- Warwicker J. A model for pH coupling of the SARS-CoV-2 spike protein open/closed equilibrium. 2021;22(2):1499 [Crossref]
16- Zahmatkesh A, Salmasi E, Gholizadeh R. Interaction of toll-like receptors and ACE-2 with different variants of SARS-CoV-2: A computational analysis. Bioimpacts. 2024;14(4):30150 [Crossref]
17- Salod Z, Mahomed O. Mapping Potential Vaccine Candidates Predicted by VaxiJen for Different Viral Pathogens between 2017–2021—A Scoping Review. Vaccines. 2022;10(11):1785 [Crossref]
18- Zou M, Lei C, Huang D, Liu L, Han Y. Application of plant-derived products as adjuvants for immune activation and vaccine development. Vaccine. 2024;42(25):126115 [Crossref]
19- EL Khatabi K, Aanouz I, Alaqarbeh M, Ajana M, Lakhlifi T, Bouachrine M. Molecular docking, molecular dynamics simulation, and ADMET analysis of levamisole derivatives against the SARS-CoV-2 main protease (MPro). Bioimpacts. 2021;12(2):107 [Crossref]
20- Khan T, Khan A, Ansari J, Najmi M, Wei D, Muhammad K, Waheed Y. Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology Approach. Molecules. 2022;27(7):2375 [Crossref]
21- Maglioco A, Agüero F, Valacco M, Valdez A, Paulino M, Fuchs A. Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts. Front Cell Infect Microbiol. 2022;12 [Crossref]
22- Wei W, Wang L, Zhou P, Jiang B, Liu H, Feng L, Ge R, Tang F, Li R. Bioinformatic prediction and identification of immunogenic epitopes of the antigenic 14-3-3 protein of Echinococcus multilocularis. Acta Tropica. 2021;220:105955 [Crossref]
23- Hafezi Ahmadi M, Mamizadeh M, Siamian D, Touyeh M, Shams M, Rashidi Y. Immunoinformatic Analysis of Leishmania Major gp46 Protein and Potential Targets for Vaccination against Leishmaniasis. RAIAD. 2024;18(2):129 [Crossref]
24- Basmenj E, Arastonejad M, Mamizadeh M, Alem M, KhalatbariLimaki M, Ghiabi S, Khamesipour A, Majidiani H, Shams M, Irannejad H. Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis. Sci Rep. 2023;13(1) [Crossref]
25- Thelen J, Leite W, Urban V, O’Neill H, Grishaev A, Curtis J, Krueger S, Castellanos M. Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles. ACS Nano. 2024;18(2):1464 [Crossref]
26- Chehelgerdi M, Chehelgerdi M. The use of RNA-based treatments in the field of cancer immunotherapy. Mol Cancer. 2023;22(1) [Crossref]
27- Majidiani H, Pourseif M, Kordi B, Sadeghi M, Najafi A. TgVax452, an epitope-based candidate vaccine targeting Toxoplasma gondii tachyzoite-specific SAG1-related sequence (SRS) proteins: immunoinformatics, structural simulations and experimental evidence-based approaches. BMC Infect Dis. 2024;24(1) [Crossref]
28- Mohammadzadeh R, Soleimanpour S, Pishdadian A, Farsiani H. Designing and development of epitope-based vaccines againstHelicobacter pylori. Critical Reviews in Microbiology. 2022;48(4):489 [Crossref]
29- Kordi B, Basmenj E, Majidiani H, Basati G, Sargazi D, Nazari N, Shams M, Shivahare R. In Silico Characterization of an Important Metacyclogenesis Marker in Leishmania donovani, HASPB1, as a Potential Vaccine Candidate. BioMed Research International. 2023;2023(1) [Crossref]
30- Wang D, Liu Y, Zhao W. The Adjuvant Effects on Vaccine and the Immunomodulatory Mechanisms of Polysaccharides From Traditional Chinese Medicine. Front Mol Biosci. 2021;8 [Crossref]
31- Pourseif M, Moghaddam G, Nematollahi A, Khordadmehr M, Naghili B, Dehghani J, Omidi Y. Vaccination with rEGVac elicits immunoprotection against different stages of Echinococcus granulosus life cycle: A pilot study. Acta Tropica. 2021;218:105883 [Crossref]
32- Masoudi-Sobhanzadeh Y, Esmaeili H, Masoudi-Nejad A. A fuzzy logic-based computational method for the repurposing of drugs against COVID-19. Bioimpacts. 2022;12(4):315 [Crossref]
33- Dehghani A, Mamizadeh M, Karimi A, Hosseini S, Siamian D, Shams M, Ghiabi S, Basati G, Abaszadeh A. Multi-epitope vaccine design against leishmaniasis using IFN-γ inducing epitopes from immunodominant gp46 and gp63 proteins. Journal of Genetic Engineering and Biotechnology. 2024;22(1):100355 [Crossref]
34- Deo S, Desai K, Patare A, Wadapurkar R, Rade S, Mahudkar S, Sathe M, Srivastava S, Prasanna P, Singh A. Evaluation of self-amplifying mRNA platform for protein expression and genetic stability: Implication for mRNA therapies. Biochemical and Biophysical Research Communications. 2023;680:108 [Crossref]
35- Han Y, Jia Z, Shi J, Wang W, He K. The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis. Bioimpacts. 2021;12(2):139 [Crossref]
36- Masoudi-Sobhanzadeh Y, Jafari B, Parvizpour S, Pourseif M, Omidi Y. A novel multi-objective metaheuristic algorithm for protein-peptide docking and benchmarking on the LEADS-PEP dataset. Computers in Biology and Medicine. 2021;138:104896 [Crossref]
37- Lotfi F, Akbarzadeh-Khiavi M, Lotfi Z, Rahbarnia L, Safary A, Zarredar H, Baghbanzadeh A, Naghili B, Baradaran B. Micronutrient therapy and effective immune response: a promising approach for management of COVID-19. Infection. 2021;49(6):1133 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge