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Bioimpacts. 2023;13(1): 63-72. doi: 10.34172/bi.2022.23904
PMID: 36816999        PMCID: PMC9923811

Original Research

Injectable thermosensitive chitosan/gelatin hydrogel for dental pulp stem cells proliferation and differentiation

Mohammad Samiei 1,2 ORCID, Elaheh Dalir Abdollahinia 1 ORCID, Nazanin Amiryaghoubi 1 ORCID, Marziyeh Fathi 1 * ORCID, Jaleh Barar 1,3 ORCID, Yadollah Omidi 4 * ORCID

Cited by CrossRef: 10

1- Amiryaghoubi N, Fathi M, Barar J, Omidian H, Omidi Y. Advanced nanoscale drug delivery systems for bone cancer therapy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2023;1869(6):166739 [Crossref]
2- Guo X, Li J, Wu Y, Xu L. Recent advancements in hydrogels as novel tissue engineering scaffolds for dental pulp regeneration. International Journal of Biological Macromolecules. 2024;264:130708 [Crossref]
3- Sonwane S, Bonde S, Bonde C, Chandarana C. Advances in gelatin-based scaffolds for tissue engineering applications: A review. Journal of Drug Delivery Science and Technology. 2025;107:106789 [Crossref]
4- Gao Y, Zhao Y, Wang T. Preparation and Characterization of Chitosan/Hydroxypropyl Methylcellulose Temperature-Sensitive Hydrogel Containing Inorganic Salts for Forest Fire Suppression. Gels. 2024;10(6):390 [Crossref]
5- Rafiee A, Mozafari N, Fekri N, Memarpour M, Azadi A. Preparation and characterization of a nanohydroxyapatite and sodium fluoride loaded chitosan-based in situ forming gel for enamel biomineralization. Heliyon. 2024;10(2):e24217 [Crossref]
6- Garshasbi H, Salehi S, Naghib S, Ghorbanzadeh S, Zhang W. Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems. Front Bioeng Biotechnol. 2023;10 [Crossref]
7- Mabied A, Tiama T, El-Sayed A, Ibrahim M. Structural characterizations, DFT, and docking of novel chitosan/PVA/germanium oxide as a potent antimicrobial agent. International Journal of Biological Macromolecules. 2025;:146577 [Crossref]
8- Amiryaghoubi N, Fathi M, Safary A, Javadzadeh Y, Omidi Y. In situ forming alginate/gelatin hydrogel scaffold through Schiff base reaction embedded with curcumin-loaded chitosan microspheres for bone tissue regeneration. International Journal of Biological Macromolecules. 2024;256:128335 [Crossref]
9- Lestari W, Irfanita N, Haris M, Lin G, Jaswir I, Darnis D, Ruziantee N, Mazlan N, Idrus E, Amir L, Fadhlina A, Sheikh H, Arzmi M. Advancements and applications of gelatin-based scaffolds in dental engineering: a narrative review. Odontology. 2025; [Crossref]
10- Ghandforoushan P, Alehosseini M, Golafshan N, Castilho M, Dolatshahi-Pirouz A, Hanaee J, Davaran S, Orive G. Injectable hydrogels for cartilage and bone tissue regeneration: A review. International Journal of Biological Macromolecules. 2023;246:125674 [Crossref]
11- Hussain M, Shahzad K, Ali A, Haseeb M, Hussain S. Development of a novel smart bio-composite hydrogel based on dextran, citric acid, and glucoxylan for pH-dependent drug delivery and stimuli-responsive swelling and release. Polymers and Polymer Composites. 2025;33 [Crossref]
12- Amiryaghoubi N, Abdollahiyan P, Fathi M, Erfan-Niya H. Injectable chitosan copolymer/gold nanoparticles/gelatin hybrid hydrogels for delivery of doxorubicin for breast cancer treatment. Polym Bull. 2024;81(15):14199 [Crossref]
13- Moghanian A, Asadi P, Akbari M, Mohammad Aliha M, Kizilkurtlu A, Akpek A, Safaee S. New trends in 3D and 4D printed dental and orthopedic Implants: Methods, applications and future directions. Bioprinting. 2025;48:e00406 [Crossref]
14- Pan H, Qu Y, Wang F, Zhao S, Chen G. Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration. Colloid and Interface Science Communications. 2025;66:100828 [Crossref]
15- Paul M, Pramanik S, Sahoo R, Dey Y, Nayak A. Dental delivery systems of antimicrobial drugs using chitosan, alginate, dextran, cellulose and other polysaccharides: A review. International Journal of Biological Macromolecules. 2023;247:125808 [Crossref]
16- Samiei M, Harmsen M, Abdolahinia E, Barar J, Petridis X. Scaffold-Free Strategies in Dental Pulp/Dentine Tissue Engineering: Current Status and Implications for Regenerative Biological Processes. Bioengineering. 2025;12(2):198 [Crossref]
17- Liu H, Shen Y. Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives. Int Endodontic J. 2025;58(5):674 [Crossref]
18- Wei Y, Zheng L, Xie X, Yang X, Liao J. Recent advances in stimuli responsive hydrogels for oral disease treatment. Materials & Design. 2024;240:112817 [Crossref]
19- Cota Quintero J, Ramos-Payán R, Romero-Quintana J, Ayala-Ham A, Bermúdez M, Aguilar-Medina E. Hydrogel-Based Scaffolds: Advancing Bone Regeneration Through Tissue Engineering. Gels. 2025;11(3):175 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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