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Bioimpacts. 2023;13(1): 63-72. doi: 10.34172/bi.2022.23904
PMID: 36816999        PMCID: PMC9923811

Original Research

Injectable thermosensitive chitosan/gelatin hydrogel for dental pulp stem cells proliferation and differentiation

Mohammad Samiei 1,2 ORCID, Elaheh Dalir Abdollahinia 1 ORCID, Nazanin Amiryaghoubi 1 ORCID, Marziyeh Fathi 1 * ORCID, Jaleh Barar 1,3 ORCID, Yadollah Omidi 4 * ORCID

Cited by CrossRef: 10

1- Amiryaghoubi N, Fathi M, Barar J, Omidian H, Omidi Y. Advanced nanoscale drug delivery systems for bone cancer therapy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2023;1869(6):166739 [Crossref]
2- Guo X, Li J, Wu Y, Xu L. Recent advancements in hydrogels as novel tissue engineering scaffolds for dental pulp regeneration. International Journal of Biological Macromolecules. 2024;264:130708 [Crossref]
3- Sonwane S, Bonde S, Bonde C, Chandarana C. Advances in gelatin-based scaffolds for tissue engineering applications: A review. Journal of Drug Delivery Science and Technology. 2025;107:106789 [Crossref]
4- Gao Y, Zhao Y, Wang T. Preparation and Characterization of Chitosan/Hydroxypropyl Methylcellulose Temperature-Sensitive Hydrogel Containing Inorganic Salts for Forest Fire Suppression. Gels. 2024;10(6):390 [Crossref]
5- Rafiee A, Mozafari N, Fekri N, Memarpour M, Azadi A. Preparation and characterization of a nanohydroxyapatite and sodium fluoride loaded chitosan-based in situ forming gel for enamel biomineralization. Heliyon. 2024;10(2):e24217 [Crossref]
6- Garshasbi H, Salehi S, Naghib S, Ghorbanzadeh S, Zhang W. Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems. Front Bioeng Biotechnol. 2023;10 [Crossref]
7- Amiryaghoubi N, Fathi M, Safary A, Javadzadeh Y, Omidi Y. In situ forming alginate/gelatin hydrogel scaffold through Schiff base reaction embedded with curcumin-loaded chitosan microspheres for bone tissue regeneration. International Journal of Biological Macromolecules. 2024;256:128335 [Crossref]
8- Ghandforoushan P, Alehosseini M, Golafshan N, Castilho M, Dolatshahi-Pirouz A, Hanaee J, Davaran S, Orive G. Injectable hydrogels for cartilage and bone tissue regeneration: A review. International Journal of Biological Macromolecules. 2023;246:125674 [Crossref]
9- Amiryaghoubi N, Abdollahiyan P, Fathi M, Erfan-Niya H. Injectable chitosan copolymer/gold nanoparticles/gelatin hybrid hydrogels for delivery of doxorubicin for breast cancer treatment. Polym Bull. 2024;81(15):14199 [Crossref]
10- Moghanian A, Asadi P, Akbari M, Mohammad Aliha M, Kizilkurtlu A, Akpek A, Safaee S. New trends in 3D and 4D printed dental and orthopedic Implants: Methods, applications and future directions. Bioprinting. 2025;48:e00406 [Crossref]
11- Pan H, Qu Y, Wang F, Zhao S, Chen G. Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration. Colloid and Interface Science Communications. 2025;66:100828 [Crossref]
12- Paul M, Pramanik S, Sahoo R, Dey Y, Nayak A. Dental delivery systems of antimicrobial drugs using chitosan, alginate, dextran, cellulose and other polysaccharides: A review. International Journal of Biological Macromolecules. 2023;247:125808 [Crossref]
13- Samiei M, Harmsen M, Abdolahinia E, Barar J, Petridis X. Scaffold-Free Strategies in Dental Pulp/Dentine Tissue Engineering: Current Status and Implications for Regenerative Biological Processes. Bioengineering. 2025;12(2):198 [Crossref]
14- Liu H, Shen Y. Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives. Int Endodontic J. 2025;58(5):674 [Crossref]
15- Wei Y, Zheng L, Xie X, Yang X, Liao J. Recent advances in stimuli responsive hydrogels for oral disease treatment. Materials & Design. 2024;240:112817 [Crossref]
16- Cota Quintero J, Ramos-Payán R, Romero-Quintana J, Ayala-Ham A, Bermúdez M, Aguilar-Medina E. Hydrogel-Based Scaffolds: Advancing Bone Regeneration Through Tissue Engineering. Gels. 2025;11(3):175 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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