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Bioimpacts. 2015;5(3): 123-127.
doi: 10.15171/bi.2015.20
PMID: 26457249
PMCID: PMC4597159
Scopus ID: 84944393625
WOSID: 000371255800003
  Abstract View: 1241
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Perspective

Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders

Khalil Ansarin 1, Maryam Khoubnasabjafari 1, Abolghasem Jouyban 2 *

1 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress needs to be re-evaluated by experts.
Keywords: Thiobarbitoric acid reactive substances, Oxidative stress, Biomarker
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Submitted: 11 Jun 2015
ePublished: 23 Aug 2017
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