Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders

Khalil Ansarin; Maryam Khoubnasabjafari; Abolghasem Jouyban

doi:10.15171/bi.2015.20

Bioimpacts. 2015;5(3): 123-127.
doi: 10.15171/bi.2015.20

PMID: 26457249
PMCID: PMC4597159
Scopus ID: 84944393625

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Perspective

Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders

Khalil Ansarin ¹, Maryam Khoubnasabjafari ¹, Abolghasem Jouyban ²^*

¹ Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
² Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

*Corresponding Author: Email: ajouyban@hotmail.com

Abstract

Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress needs to be re-evaluated by experts.

Keywords: Thiobarbitoric acid reactive substances, Oxidative stress, Biomarker

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