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Bioimpacts. 2017;7(3): 177-192.
doi: 10.15171/bi.2017.21
PMID: 29159145
PMCID: PMC5684509
Scopus ID: 85032022388
  Abstract View: 2493
  PDF Download: 1789
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Original Research

pH responsive cross-linked polymeric matrices based on natural polymers: effect of process variables on swelling characterization and drug delivery properties

Fahad Naeem 1, Samiullah Khan 2*, Aamir Jalil 1, Nazar Muhammad Ranjha 1, Amina Riaz 1, Malik Salman Haider 1, Shoaib Sarwar 1, Fareha Saher 1, Samrin Afzal 1

1 Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800 Pakistan
2 Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur 63100, Punjab, Pakistan
*Corresponding Author: Email: sami_pharmacist99@hotmail.com

Abstract

Introduction: The current work was aimed to design and synthesize novel crosslinked pH-sensitive gelatin/pectin (Ge/Pec) hydrogels using different polymeric ratios and to explore the effect of polymers and degree of crosslinking on dynamic, equilibrium swelling and in vitro release behavior of the model drug (Mannitol).
Methods: The Ge/Pec based hydrogels were prepared using glutaraldehyde as the crosslinker. Various structural parameters that affect their release behavior were determined, including swelling study, porosity, sol-gel analysis, average molecular weight between crosslinks (Mc), volume fraction of polymer (V2,s), solvent interaction parameter (χ) and diffusion coefficient. The synthesized hydrogels were subjected to various characterization tools like Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and DSC differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).
Results: The hydrogels show highest water uptake and release at lower pH values. The FTIR spectra showed an interaction between Ge and Pec, and the drug-loaded samples also showed the drug-related peaks, indicating proper loading of the drug. DSC and TGA studies confirmed the thermal stability of hydrogel samples, while SEM showed the porous nature of hydrogels. The drug release followed non-Fickian diffusion or anomalous mechanism.
Conclusion: Aforementioned characterizations reveal the successful formation of copolymer hydrogels. The pH-sensitive swelling ability and drug release behavior suggest that the rate of polymer chain relaxation and drug diffusion from these hydrogels are comparable which also predicts their possible use for site-specific drug delivery.
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Submitted: 19 Feb 2017
Revision: 15 Jul 2017
Accepted: 16 Jul 2017
ePublished: 16 Aug 2017
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