BioImpacts. 2021;11(1): 45-52.
doi: 10.34172/bi.2021.06
PMID: 33469507
PMCID: PMC7803922
Scopus ID: 85099173455
  Abstract View: 319
  PDF Download: 218

Original Research

PLGA/TiO2 nanocomposite scaffolds for biomedical applications: fabrication, photocatalytic, and antibacterial properties

Seyedeh Sogol Pelaseyed 1 ORCID logo, Hamid Reza Madaah Hosseini 1* ORCID logo, Zeinab Nokhbedehghan 2,3, Ali Samadikuchaksaraei 2,3,4

1 Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
2 Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Cellular and Molecular Research Center, Tehran, Iran
4 Department of Tissue Engineering and Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran


Introduction: Porous 3D scaffolds synthesized using biocompatible and biodegradable materials could provide suitable microenvironment and mechanical support for optimal cell growth and function. The effect of the scaffold porosity on the mechanical properties, as well as the TiO2 nanoparticles addition on the bioactivity, antimicrobial, photocatalytic, and cytotoxicity properties of scaffolds were investigated.
Methods: In the present study, porous scaffolds consisting poly (lactide-co-glycolide) (PLGA) containing TiO2 nanoparticles were fabricated via air-liquid foaming technique, which is a novel method and has more advantages due to not using additives for nucleation compared to former ways.
Results: Adjustment of the foaming process parameters was demonstrated to allow for textural control of the resulting scaffolds and their pore size tuning in the range of 200–600 μm. Mechanical properties of the scaffolds, in particular, their compressive strength, revealed an inverse relationship with the pore size, and varied in the range of 0.97–0.75 MPa. The scaffold with the pore size 270 μm, compressive strength 0.97 MPa, and porosity level 90%, was chosen as the optimum case for the bone tissue engineering (BTE) application. Furthermore, 99% antibacterial effect of the PLGA/10 wt.% TiO2 nanocomposite scaffolds against the strain was achieved using Escherichia coli. Besides, no negative effect of the new method was observed on the bioactivity behavior and apatite forming ability of scaffolds in the simulated body fluid (SBF). This nanocomposite also displayed a good cytocompatibility when assayed with MG 63 cells. Lastly, the nanocomposite scaffolds revealed the capability to degrade methylene blue (MB) dye by nearly 90% under the UV irradiation for 3 hours.
Conclusion: Based on the results, nanocomposite new scaffolds are proposed as a promising candidate for the BTE applications as a replacement for the previous ones.
Keywords: Scaffold, PLGA, Biocompatibility, Antibacterial, Photocatalytic properties
First Name
Last Name
Email Address
Security code

Abstract View: 305

Your browser does not support the canvas element.

PDF Download: 218

Your browser does not support the canvas element.

Submitted: 04 Dec 2019
Revision: 07 Mar 2020
Accepted: 16 Mar 2020
ePublished: 27 May 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)