Yadollah Omidi  , Abass Alavi*
Mohammad Rafi (Persian: محمد رفیع ) obtained his PhD from University of Montpellier, France, in 1970. Investigating lysosomal storage diseases, he focused on gene therapy of neurodegenerative disorders using globoid cell leukodystrophy (Krabbe disease) animal models. With successful AAVrh10-mediated therapy in animal models, his research is moving towards human clinical trials.
|
Roya Dolatkhah , Saeed Dastgiri , Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi*
It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.
|
Reddy Amala, Sundaresan Sujatha*
LPS stimulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by binding toTLR-4. iNOS produced enormous nitric oxide (NO) that stimulated COX-2 activity and prostaglandin E2 which further induced the production of pro-inflammatory cytokines leading to inflammation. ALK-F of A. vasica could attenuate iNOS and COX-2 gene expression reducing NO production.
|
Malkiet Kaur , Manju Nagpal* , Manjinder Singh , Thakur Gurjeet Singh, Geeta Aggarwal , Gitika Arora Dhingra
Cinnamon essential oil (CEO) is a volatile oil, obtained from Cinnamomum zeylanicum has become one of the most important natural oil due to its antimicrobial activity. CEO suffers from various limitations such as instability and skin irritation.
|
Nurul Azmir Amir Hashim , Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, Nurul Syakima Ab Mutalib, Ismail Sagap, A. Rahman A. Jamal, Musalmah Mazlan*
Global Serum from metabolomics on colorectal cancer (CRC) identified 11 differential metabolites which able to identify a new set of sample with 80% of accuracy. Pathway analysis shows purine, catecholamine and amino acid metabolism were altered in CRC patients.
|
Seyedeh Sogol Pelaseyed , Hamid Reza Madaah Hosseini* , Zeinab Nokhbedehghan, Ali Samadikuchaksaraei
Highly porous scaffolds consisting of poly (lactide-co-glycolide) containing TiO2 nanoparticles were fabricated via air-liquid foaming technique, which is a novel method and has more advantages by using no additives for nucleation compared to former ways.
|
Farzaneh Barati , Ezat Asgarani* , Sara Gharavi, Mohammad Reza Soudi
Overexpression of phbC, the critical gene in PHB biosynthesis pathway, in R. eutropha PTCC 1615 had considerable effect on PHB accumulation.
|
Muhammad H. Sultan , Wael A. Mahdi, Young M. Kwon*
Pluronic F127 limits tissue enzymes to act on protamine on NPH insulin microcrystals to prevent acceleration of insulin release and help control blood glucose in STZ-induced diabetic rats uponsubcutaneous administration.
|
Original Research
COVID-19
Mohammad Mostafa Pourseif , Sepideh Parvizpour, Behzad Jafari, Jaber Dehghani , Behrouz Naghili, Yadollah Omidi*
Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.
|