BioImpacts. 2021;11(2): 85-86.
doi: 10.34172/bi.2021.15
PMID: 33842278
PMCID: PMC8022233
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Targeted delivery of thrombolytic enzymes

Young M. Kwon 1* ORCID logo

1 Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Nova Southeastern University 3200 S. University Dr. Fort Lauderdale, FL 33328


Although thrombolytic agents have been used for several decades in the treatment of thromboembolic conditions, there is an unmet need for the development of safer thrombolytic agents. The development of new molecules themselves may not be sufficient. This has sparked a growing interest in the design of novel nanoscale drug carrier systems for the delivery of thrombolytic enzymes in an effort to address its fatal side effects. There are numerous proof-of-concept reports on such nanoscale systems that seek to capitalize on the pathophysiologic signatures of thrombosis as well as external biochemical/physical triggers. Although there may be a long road ahead before we have such new nanoscale therapeutics on the bedside, hopes remain high.
Keywords: Thrombolytics, Targeted delivery, tPA, Nanocarriers
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Submitted: 25 Aug 2020
Accepted: 06 Sep 2020
ePublished: 29 Oct 2020
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