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Editorial
Young M. Kwon* ORCID
BioImpacts. 2021;11(2): 85-86. doi: 10.34172/bi.2021.15
PMCID: PMC8022233     PMID: 33842278    
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Young M. Kwon received his Ph.D. from University of Utah (USA) and his postdoctoral training at University of Michigan (USA). He is currently an Associate Professor of Pharmaceutical Sciences at Nova Southeastern University College of Pharmacy (USA). Dr. Kwon’s research interests include targeted delivery and controlled release of biological molecules.
Original Research
Amin Khodaei ORCID, Mohammad-Reza Feizi-Derakhshi* ORCID, Behzad Mozaffari-Tazehkand ORCID
BioImpacts. 2021;11(2): 87-99. doi: 10.34172/bi.2021.16
PMCID: PMC8022238     PMID: 33842279    
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In this research, cancer data are analyzed in the form of DNA in terms of nucleotide sequences. A hybrid machine learning and statistical approach was used for classification of genomic sequences.
Original Research
Faegheh Golabi ORCID, Elnaz Mehdizadeh Aghdam ORCID, Mousa Shamsi* ORCID, Mohammad Hossein Sedaaghi ORCID, Abolfazl Barzegar ORCID, Mohammad Saeid Hejazi* ORCID
BioImpacts. 2021;11(2): 101-109. doi: 10.34172/bi.2021.17
PMCID: PMC8022236     PMID: 33842280    
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Block Location-Based Feature Extraction strategy (BLBFE) method was recently introduced as an alignment-free algorithm to classify riboswitches. Employing BLBFE method accompanied by KNN or decision tree classifiers results in better performance in the classification of riboswitches.
Original Research
Elaheh Dalir Abdolahinia, Behzad Jafari, Sepideh Parvizpour, Jaleh Barar ORCID, Samad Nadri*, Yadollah Omidi* ORCID
BioImpacts. 2021;11(2): 111-117. doi: 10.34172/bi.2021.18
PMCID: PMC8022235     PMID: 33842281    
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Based on in vitro and in silico findings, MC is suggested as an important ECMmimicking entity that can support the semi-solid medium and promote the formation of the uniform spheroid in the 3D culture.
Original Research
G Divyashri* ORCID, T P Krishna Murthy, Subramaniam Sundareshan, Pavan Kamath, Manikanta Murahari*, G R Saraswathy, Bindu Sadanandan
BioImpacts. 2021;11(2): 119-127. doi: 10.34172/bi.2021.19
PMCID: PMC8022237     PMID: 33842282    
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Novel inhibitors from Mango ginger were identified against five drug targets of H. pylori. In silico potential of Mango ginger compound, gentisic acid with the drug target, shikimate kinase was evaluated. Results were found promising without any limitations.
Original Research
Parisa Ebrahimisadr* ORCID, Zahra Bakhshandeh, Hamidreza Majidiani
BioImpacts. 2021;11(2): 129-133. doi: 10.34172/bi.2021.20
PMCID: PMC8022230     PMID: 33842283    
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One of the major complications in thalassemia patients is alloimmunization, The best way to manage alloimmunized patients is to identify the type of alloantibodies with antibody screening and identification tests and blood transfusion of the negative antigen.
Original Research
Mohammad A Rafi* ORCID, Paola Luzi, David A Wenger ORCID
BioImpacts. 2021;11(2): 135-146. doi: 10.34172/bi.2021.21
PMCID: PMC8022232     PMID: 33842284    
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Our results demonstrate that, it may be possible to treat human KD patients with high dose AAVrh10 without blood stem cell transplantation which would eliminate the side effects of HSCT.
Original Research
Hazwani Mohd Yusof ORCID, Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, A Rahman A Jamal, Musalmah Mazlan* ORCID
BioImpacts. 2021;11(2): 147-156. doi: 10.34172/bi.2021.22
PMCID: PMC8022234     PMID: 33842285    
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This study highlights the differential metabolite profiling in CRC cell lines corresponding to different stages.
Original Research
Seyed Mehdi Kamali Shahri ORCID, Christian Contarino, Francesco Chifari, Morteza Mahmoudi*, Simon Gelman* ORCID
BioImpacts. 2021;11(2): 157-164. doi: 10.34172/bi.2021.13
PMCID: PMC8022231     PMID: 33842286    
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The behavior of vasculature was mathematically examined in conditions of eliminated cardiac function. Results show vein responses slower than artery in simulated cardiac arrest due to different intrinsic characteristics. Additionally, the stretch-recoil capability of the vein found important in blood displacement.