Logo-bi
Bioimpacts. 2024;14(6): 30136.
doi: 10.34172/bi.2024.30136
  Abstract View: 582
  PDF Download: 472

Review

A comprehensive review on alpha-lipoic acid delivery by nanoparticles

Navid Mosallaei 1 ORCID logo, Amirhossein Malaekeh-Nikouei 2 ORCID logo, Setayesh Sarraf Shirazi 2, Javad Behmadi 2, Bizhan Malaekeh-Nikouei 1,3* ORCID logo

1 Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, ‎Mashhad, Iran
2 Student research committee, School of Pharmacy, Mashhad University of Medical Sciences, ‎Mashhad, Iran
3 Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of ‎Medical Sciences, Mashhad, Iran
*Corresponding Author: Bizhan Malaekeh-Nikouei, , Email: malaekehb@mums.ac.ir

Abstract

Alpha-lipoic acid (ALA) has garnered significant attention for its potential therapeutic benefits across a wide spectrum of health conditions. Despite its remarkable antioxidant properties, ALA is hindered by challenges such as low bioavailability, short half-life, and unpleasant odor. To overcome these limitations and enhance ALA's therapeutic efficacy, various nanoparticulate drug delivery systems have been explored. This comprehensive review evaluates the application of different nanoparticulate carriers, including lipid-based nanoparticles (solid lipid nanoparticles, niosomes, liposomes, nanostructured lipid carriers (NLCs), and micelles), nanoemulsions, polymeric nanoparticles (nanocapsules, PEGylated nanoparticles, and polycaprolactone nanoparticles), films, nanofibers, and gold nanoparticles, for ALA delivery. Each nanoparticulate system offers unique advantages, such as improved stability, sustained release, enhanced bioavailability, and targeted delivery. For example, ALA-loaded SLNs demonstrated benefits for skin care products and skin rejuvenation. ALA encapsulated in niosomes showed potential for treating cerebral ischemia, a condition largely linked to stroke. ALA-loaded cationic nanoemulsions showed promise for ophthalmic applications, reducing vascular injuries, and corneal disorders. Coating liposomes with chitosan further enhanced stability and performance, promoting drug absorption through the skin. This review provides a comprehensive overview of the advancements in nanoparticulate delivery systems for ALA, highlighting their potential to overcome the limitations of ALA administration and significantly enhance its therapeutic effectiveness. These innovative approaches hold promise for the development of improved ALA-based treatments across a broad spectrum of health conditions.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 582

Your browser does not support the canvas element.


PDF Download: 472

Your browser does not support the canvas element.

Submitted: 30 Sep 2023
Revision: 02 Dec 2023
Accepted: 03 Dec 2023
ePublished: 26 Feb 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)