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Bioimpacts. 2024;14(6): 30136. doi: 10.34172/bi.2024.30136
PMID: 39493899        PMCID: PMC11530970

Review

A comprehensive review on alpha-lipoic acid delivery by nanoparticles

Navid Mosallaei 1 ORCID, Amirhossein Malaekeh-Nikouei 2 ORCID, Setayesh Sarraf Shirazi 2, Javad Behmadi 2, Bizhan Malaekeh-Nikouei 1,3 * ORCID

Cited by CrossRef: 8

1- Ta P, Bernat‐Just L, Alambiaga‐Caravaca A, Rodilla V, López‐Castellano A, Bosch‐Morell F. Optimization and Validation of a High‐Performance Liquid Chromatography (HPLC‐UV) Method for Quantification of α‐Lipoic Acid in Cyclodextrins Complex for Ocular Delivery. Biomedical Chromatography. 2025;39(7) [Crossref]
2- Sarhan A, Haririan I, Akrami M, Saadatnia F, GE Z. Enhanced anticancer efficacy of α-lipoic acid-loaded TPGS micelles: Synthesis, characterization, and evaluation in a 4T1 breast cancer model. Bioimpacts. 2026;16:31242 [Crossref]
3- Li M, Li Z, Fan Y. Omega-3 fatty acids: multi-target mechanisms and therapeutic applications in neurodevelopmental disorders and epilepsy. Front Nutr. 2025;12 [Crossref]
4- Ścisłowska-Czarnecka A, Matuła A, Stodolak-Zych E, Lizak A, Homa J, Stenka B, Chadzinska M, Bac A. Modulation of resting macrophage activity via low-level laser therapy (LLLT) and α-lipoic acid: an in vitro study using a PCL-based biomaterial. Sci Rep. 2026;16(1) [Crossref]
5- Guan Y, Liu J, Yang J, Chen S, Yao W, Gong S, Xiao C, Li M, Luo G, Hei Z. Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q10 delivery attenuate hepatic ischemia-reperfusion injury via ROS scavenging and ferroptosis inhibition. J Mater Chem B. 2025;13(33):10159 [Crossref]
6- Dadhich A, Sharma Y, Verma A, Nema R, Sharma M. Bacoside-A from Bacopa monnieri (L.) Wettst.: Molecular targets, preclinical insights, and therapeutic potential in type 2 diabetes mellitus and neurodegeneration. Biomedicine & Pharmacotherapy. 2025;191:118466 [Crossref]
7- Mateo Orobia A, Benítez del Castillo J, Calonge M, Baudouin C, Labetoulle M. A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease. Acta Ophthalmologica. 2025;103(6) [Crossref]
8- Serhiyenko V, Chemerys O, Holovach S, Serhiyenko A. Post-traumatic stress disorder, diabetes mellitus, and alpha-lipoic acid. Mìžnarodnij endokrinologìčnij žurnal. 2025;21(1):82 [Crossref]
9- Galla R, Ferrari S, Mulè S, Nebuloni M, Calvi M, Botta M, Uberti F. Enhancing Nutraceutical Efficacy: The Role of M.A.T.R.I.S. Technology in Modulating Intestinal Release of Lipoic Acid and L-Carnitine. IJMS. 2025;26(10):4866 [Crossref]
10- Dutra‐Portes S, Alves C, Matos B, Gratieri T, Cunha‐Filho M, Lima E, Gelfuso G. Chromatographic Method Validation for Simultaneous Determination of Bergenin and Alpha‐Lipoic Acid in Skin Penetration Studies. Biomedical Chromatography. 2026;40(8) [Crossref]
11- Saliev T, Singh P. From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications. Cells. 2024;13(24):2052 [Crossref]

Poster

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 19% 
Publication fee: Free of charge

Indexing/Abstracting Info
PubMed; PubMed Central; Scopus; Science Citation Index Expanded; Google Scholar;   SJR; Essential Science Indicators; Embase; EBSCOhost; CAS: DOAJ: SHERPA/RoMEO
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Follower of ICMJE
Permission: Creative Commons