1. Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats

Arezoo Gohari Mahmoudabad , Fatemeh Gheybi, Mohsen Mehrabi* , Alireza Masoudi, Zeinab Mobasher, Hamid Vahedi, Anneh Mohammad Gharravi, Fatemeh Sadat Bitaraf, Seyed Mahdi Rezayat Sorkhabadi

Bioimpacts. 2023;13(4): 301-311. doi: 10.34172/bi.2023.24128

PMCID: PMC10460772 PMID: 37645028 Scopus ID: 85168161377

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Phytosome silymarin nanoparticles effectively improved ethanol-induced liver damage in models of rats with alcoholic liver disease (ALD) and showed higher beneficial effects and less toxicity compared to the bulky form of phytosome silymarin nanoparticles.

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