1. Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers

Fatemeh Khonsari , Mostafa Heydari , Rassoul Dinarvand , Mohammad Sharifzadeh , Fatemeh Atyabi*

Bioimpacts. 2022;12(1): 21-32. doi: 10.34172/bi.2021.23389

PMCID: PMC8783081 PMID: 35087713 Scopus ID: 85127207881

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Nanostructured-Lipid-Carriers (NLCs) for brain delivery of rapamycin were designed by modification of optimized cationic-NLCs (C-NLC) with different approaches. The targeted transferrin decorated NLCs(Tf-NLCs) in comparison to untargeted bare-NLCs (B-NLCs) showed higher cellular uptake and appropriate targeted accumulation in the brain.

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