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Bioimpacts. 2016;6(3): 125-133. doi: 10.15171/bi.2016.19
PMID: 27853676        PMCID: PMC5108985

Original Research

Interactions of cephalexin with bovine serum albumin: displacement reaction and molecular docking

Hamed Hamishehkar 1, Soheila Hosseini 2, Abdolhossein Naseri 3, Azam Safarnejad 2, Farzaneh Rasoulzadeh 1 *

Cited by CrossRef: 28

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2- Jalili R, Irani-nezhad M, Khataee A, Joo S. A ratiometric fluorescent probe based on carbon dots and gold nanocluster encapsulated metal–organic framework for detection of cephalexin residues in milk. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021;262:120089 [Crossref]
3- Maleki S, Arabzadeh A, Nejati K, Fathi F. Exploring The Interactions of a Natural Gamma-Oryzanol with Human Serum Albumin: Surface Plasmon Resonance, Fluorescence, and Molecular Modeling Studies. Drug Res (Stuttg). 2021;71(09):520 [Crossref]
4- Monirinasab H, Zakariazadeh M, Kohestani H, Kouhestani M, Fathi F. Study of β-lactam-based drug interaction with albumin protein using optical, sensing, and docking methods. J Biol Phys. 2022;48(2):177 [Crossref]
5- Liu K, Zhang Y, Zhang W, Liu L, Yu Z. A Study on the Interactions of Proteinase K with Myricetin and Myricitrin by Multi-Spectroscopy and Molecular Modeling. IJMS. 2023;24(6):5317 [Crossref]
6- Shaghaghi M, Rashtbari S, Vejdani S, Dehghan G, Jouyban A, Yekta R. Exploring the interactions of a Tb(III)–quercetin complex with serum albumins (HSA and BSA): spectroscopic and molecular docking studies. Luminescence. 2020;35(4):512 [Crossref]
7- Chisana N, Banharak S, Panpanit L, Chanaboon S, Tipkanjanaraykha K. Study of medication use and effects of medication among hospitalized older Buddhist monks: An embedded mixed‐method study. Journal of Advanced Nursing. 2023;79(9):3609 [Crossref]
8- Chaudhary T, Chaudhary M, Joshi B, de Santana M, Ayala A. Spectroscopic (FT-IR, Raman) analysis and computational study on conformational geometry, AIM and biological activity of cephalexin from DFT and molecular docking approach. Journal of Molecular Structure. 2021;1240:130594 [Crossref]
9- Sakthikumar K, Isamura B, Krause R. An Integrated Analysis of Mechanistic Insights into Biomolecular Interactions and Molecular Dynamics of Bio-Inspired Cu(II) and Zn(II) Complexes towards DNA/BSA/SARS-CoV-2 3CLpro by Molecular Docking-Based Virtual Screening and FRET Detection. Biomolecules. 2022;12(12):1883 [Crossref]
10- Ramachandran T, Vinod S, Murugan Sreedevi S, Gunasekaran S, Perumal T, Chinnadurai R, Rajendran K. Molecular docking studies on the binding interaction and stability of ovalbumin with an intramolecular charge transfer dye 4-dicyanomethylene-2,6-dimethyl-4H-pyran in the presence of an antibiotic: Tetracycline. Journal of the Indian Chemical Society. 2022;99(10):100681 [Crossref]
11- Patar M, Jalan A, Moyon N. A Fluorescence and Molecular Docking Study on the Interaction of 4′-Hydroxychalcone with Bovine Serum Albumin and Human Serum Albumin. Asian J Chem. 2022;34(7):1711 [Crossref]
12- Sakthikumar K, Krause R, Isamura B, Rizzarelli E. Comprehensive Assessment of Biomolecular Interactions of Morpholine‐Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′‐Bipyridine as Potential Anticancer and SARS‐CoV‐2 Agents: A Synergistic Experimental and Structure‐Based Virtual Screening. Bioinorganic Chemistry and Applications. 2022;2022(1) [Crossref]
13- Tissopi R, Rupreo V, Chaudhuri S, Bhattacharyya J. On surface binding of serum albumin by harmane: An in vitro spectroscopic and theoretical analysis. Journal of Molecular Liquids. 2024;409:125311 [Crossref]
14- Khatun S, Khatun R, Qais F. In-vitro binding analysis of bovine serum albumin with sulindac/chlorpromazine: Spectroscopic, calorimetric and computational approaches. Journal of Molecular Liquids. 2020;299:112124 [Crossref]
15- Trusova V, Tarabara U, Zhytniakivska O, Vus K, Gorbenko G. Probing the interactions of novel europium coordination complexes with serum albumin. Luminescence. 2021;36(3):795 [Crossref]
16- Thorve M, Kishore N. Binding and displacement study of gentamicin, 5-fluorouracil, oxytetracycline and rolitetracycline with (BSA: Drug2) complex using spectroscopic and calorimetric techniques: Biophysical approach. International Journal of Biological Macromolecules. 2024;276:133677 [Crossref]
17- Ahmed M, Molla M, Saha M, Shahriar I, Rahman M, Halim M, Rub M, Hoque M, Asiri A. Aggregation behavior of cetyldimethylethylammonium bromide under the influence of bovine serum albumin in aqueous/electrolyte solutions at various temperatures and compositions: conductivity and molecular dynamics study. RSC Adv. 2019;9(12):6556 [Crossref]
18- Jana G, Nayim S, Sahoo N, Das S, Aktara M, Patra A, Islam M, Hossain M. Deciphering the positional impact of chlorine in a new series of berberine analogues towards the superb-selective “turn-on” hydrophobic signaling of bovine serum albumin at physiological pH. New J Chem. 2020;44(5):1761 [Crossref]
19- Sakthikumar K, Krause R, Isamura B, Raja J, Athimoolam S. Spectro-electrochemical, fluorometric and biothermodynamic evaluation of pharmacologically active morpholine scaffold single crystal ligand and its metal(II) complexes: A comparative study on in-vitro and in-silico screening towards DNA/BSA/SARS-CoV-19. Journal of Inorganic Biochemistry. 2022;236:111953 [Crossref]
20- Hansda C, Maiti P, Singha T, Pal M, Hussain S, Paul S, Paul P. Photophysical study of the interaction between ZnO nanoparticles and globular protein bovine serum albumin in solution and in a layer-by-layer self-assembled film. Journal of Physics and Chemistry of Solids. 2018;121:110 [Crossref]
21- Gu J, Liu L, Zheng S, Yang G, He Q, Huang X, Guo C. Investigation of the binding interactions between 17α-ethinylestradiol with bovine serum albumin by multispectroscopy. Journal of Environmental Science and Health, Part A. 2020;55(9):1131 [Crossref]
22- Pandit S, Bapli A, Gautam R, Jana R, Seth D. Spectroscopic investigation of a red emitting dye in the companionship of serum albumins and cucurbit[7]uril. Journal of Molecular Liquids. 2021;332:115885 [Crossref]
23- Nayim S, Chandra Jana G, Aktara M, Khatun M, Das S, Islam M, Jha P, Hossain M. Berberine derivatives as heteroatom induced hydrophobic sensor: An analytical approach for the selective and sensitive fluorometric detection and discrimination of serum albumins. Analytica Chimica Acta. 2019;1065:124 [Crossref]
24- Sakthikumar K, Kabuyaya Isamura B, Krause R. Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes – combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CLPro. RSC Med Chem. 2023;14(9):1667 [Crossref]
25- Banu A, Naqvi S, Qashqoosh M, Manea Y. Multispectroscopic and computational study of interaction of the bovine serum albumin with atropine and atropine-loaded chitosan nanoparticles (synthesized and characterized). Journal of Biomolecular Structure and Dynamics. 2023;41(20):11137 [Crossref]
26- Garcia P, Coronel Arrechea C, Velo A, Riva J, Yudi L, Argüello G. Interaction of polypyridyl Cr(III) complexes with bovine serum albumin. Eur Biophys J. 2020;49(2):125 [Crossref]
27- Arsalan A, Qadeer K, Ali S, Ahmed S, Khan R, Sheraz M, Hassan S, Ahmad I. The effect of albumin in photostabilization of riboflavin: A kinetic study. Journal of Photochemistry and Photobiology A: Chemistry. 2020;394:112456 [Crossref]
28- Khatun S, Khatun R. Probing of the binding profile of anti-hypertensive drug, captopril with bovine serum albumin: A detailed calorimetric, spectroscopic and molecular docking studies. The Journal of Chemical Thermodynamics. 2018;126:43 [Crossref]
29- Shahabadi N, Hashempour S, Taherpour A, Mohsenzadeh F. Synthesis, characterization, HSA interaction, and antibacterial activity of a new water-soluble Pt(II) complex containing the drug cephalexin. Journal of Coordination Chemistry. 2018;71(22):3708 [Crossref]
30- Ma Y, Sheng J, Yan F, Wei W, Li L, Liu L, Sun J. Potential binding of cryptotanshinone with hemoglobin and antimetastatic effects against breast cancer cells through alleviating the expression of MMP-2/-9. Arabian Journal of Chemistry. 2023;16(10):105071 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge