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Bioimpacts. 2017;7(3): 167-175. doi: 10.15171/bi.2017.20
PMID: 29159144        PMCID: PMC5684508

Original Research

Thermoresponsive graphene oxide – starch micro/nanohydrogel composite as biocompatible drug delivery system

Mina Sattari 1, Marziyeh Fathi 1, Mansour Daei 2, Hamid Erfan-Niya 2 * , Jaleh Barar 1 ORCID, Ali Akbar Entezami 3

Cited by CrossRef: 21


1- Jain S, Jain A, Jain R, Chauhan N. Potential of natural polymeric materials in pharmaceutics. Pharmacological Research - Natural Products. 2024;2:100014 [Crossref]
2- Yu M, Ji N, Wang Y, Dai L, Xiong L, Sun Q. Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components. Comp Rev Food Sci Food Safe. 2021;20(1):1075 [Crossref]
3- Rahimi S, Chen Y, Zareian M, Pandit S, Mijakovic I. Cellular and subcellular interactions of graphene-based materials with cancerous and non-cancerous cells. Advanced Drug Delivery Reviews. 2022;189:114467 [Crossref]
4- Khakpour E, Salehi S, Naghib S, Ghorbanzadeh S, Zhang W. Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules. Front Bioeng Biotechnol. 2023;11 [Crossref]
5- Kondo S, Nishimura T, Nishina Y, Sano K. Countercation Engineering of Graphene-Oxide Nanosheets for Imparting a Thermoresponsive Ability. ACS Appl Mater Interfaces. 2023;15(31):37837 [Crossref]
6- Dewangan R, Asthana A, Singh A, Carabineiro S. Synthesis, characterization and antibacterial activity of a graphene oxide based NiO and starch composite material. Journal of Dispersion Science and Technology. 2022;43(4):559 [Crossref]
7- Işıklan N, Hussien N, Türk M. Synthesis and drug delivery performance of gelatin-decorated magnetic graphene oxide nanoplatform. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021;616:126256 [Crossref]
8- Fathi M, Alami-Milani M, Geranmayeh M, Barar J, Erfan-Niya H, Omidi Y. Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer. International Journal of Biological Macromolecules. 2019;128:957 [Crossref]
9- Davoodi‐Monfared P, Akbari‐Birgani S, Mohammadi S, Kazemi F, Nikfarjam N, Nikbakht M, Mousavi S. Synthesis, characterization, and in vitro evaluation of the starch‐based α‐amylase responsive hydrogels. Journal Cellular Physiology. 2021;236(5):4066 [Crossref]
10- Sarvari R, Naghili B, Agbolaghi S, Abbaspoor S, Bannazadeh Baghi H, Poortahmasebi V, Sadrmohammadi M, Hosseini M. Organic/polymeric antibiofilm coatings for surface modification of medical devices. International Journal of Polymeric Materials and Polymeric Biomaterials. 2023;72(11):867 [Crossref]
11- Diaz-Baca J, Fatehi P. Temperature responsive crosslinked starch-kraft lignin macromolecule. Carbohydrate Polymers. 2023;313:120846 [Crossref]
12- Levenez B, Gil-Cortes T, Rodríguez-Fuentes N, Jiménez J, Herrera-Kao W, Loría-Bastarrachea M, May-Pat A, Guerrero-Bermea C, Uribe-Calderón J, Cervantes-Uc J. Silanized graphene oxide as a reinforcing agent for acrylic bone cements: physicochemical, mechanical and biological characterization. Journal of Biomaterials Science, Polymer Edition. 2021;32(13):1736 [Crossref]
13- Onder A, Kıvanç M, Durmuş S, Ilgin P, Ozay H, Ozay O. Adsorption of Malachite Green from Aqueous Solution Using Hydroxyethyl Starch Hydrogel Improved by Graphene Oxide. J Polym Environ. 2022;30(7):2928 [Crossref]
14- Drozd N, Kuleshova S, Torlopov M, Udoratina E. Hemorrhagic Activity of Cationic Starch Conjugates with Sterically Hindered Phenol after Intravenous Administration to Guinea Pigs. Bull Exp Biol Med. 2023;176(2):227 [Crossref]
15- Samiei M, Fathi M, Barar J, Fathi N, Amiryaghoubi N, Omidi Y. Bioactive hydrogel-based scaffolds for the regeneration of dental pulp tissue. Journal of Drug Delivery Science and Technology. 2021;64:102600 [Crossref]
16- Stengelin E, Thiele J, Seiffert S. Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing. Advanced Science. 2022;9(10) [Crossref]
17- Hashemzadeh N, Dolatkhah M, Aghanejad A, Barzegar-Jalali M, Omidi Y, Adibkia K, Barar J. Folate Receptor-Mediated Delivery of 1-MDT-Loaded Mesoporous Silica Magnetic Nanoparticles to Target Breast Cancer Cells. Nanomedicine (Lond). 2021;16(24):2137 [Crossref]
18- Jiang C, Qi Z, Jia H, Huang Y, Wang Y, Zhang W, Wu Z, Yang H, Liu J. ATP-Responsive Low-Molecular-Weight Polyethylenimine-Based Supramolecular Assembly via Host–Guest Interaction for Gene Delivery. Biomacromolecules. 2019;20(1):478 [Crossref]
19- Motamedi E, Motesharezedeh B, Shirinfekr A, Samar S. Synthesis and swelling behavior of environmentally friendly starch-based superabsorbent hydrogels reinforced with natural char nano/micro particles. Journal of Environmental Chemical Engineering. 2020;8(1):103583 [Crossref]
20- Eivazzadeh-Keihan R, Radinekiyan F, Madanchi H, Aliabadi H, Maleki A. Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties. Carbohydrate Polymers. 2020;248:116802 [Crossref]


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge