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Bioimpacts. 2015;5(2): 103-111. doi: 10.15171/bi.2015.10
PMID: 26191505        PMCID: PMC4492185

Review

Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery

Samira Jafari 1,2, Solmaz Maleki Dizaj 1,2, Khosro Adibkia 3 *

Cited by CrossRef: 52

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9- Li Z, Wang X, Teng D, Mao R, Hao Y, Yang N, Chen H, Wang X, Wang J. Improved antibacterial activity of a marine peptide-N2 against intracellular Salmonella typhimurium by conjugating with cell-penetrating peptides-bLFcin 6 /Tat 11. European Journal of Medicinal Chemistry. 2018;145:263 [Crossref]
10- Singh T, Murthy A, Yang H, Im J. Versatility of cell-penetrating peptides for intracellular delivery of siRNA. Drug Delivery. 2018;25(1):1996 [Crossref]
11- Habault J, Poyet J. Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies. Molecules. 2019;24(5):927 [Crossref]
12- Li Z, Teng D, Mao R, Wang X, Hao Y, Wang X, Wang J. Improved Antibacterial Activity of the Marine Peptide N6 against Intracellular Salmonella Typhimurium by Conjugating with the Cell-Penetrating Peptide Tat11 via a Cleavable Linker. J Med Chem. 2018;61(17):7991 [Crossref]
13- Jafari S, Ahmadian E, Fard J, Yari Khosroushahi A. Biomacromolecule based nanoscaffolds for cell therapy. Journal of Drug Delivery Science and Technology. 2017;37:61 [Crossref]
14- Perillo E, Hervé-Aubert K, Allard-Vannier E, Falanga A, Galdiero S, Chourpa I. Synthesis and in vitro evaluation of fluorescent and magnetic nanoparticles functionalized with a cell penetrating peptide for cancer theranosis. Journal of Colloid and Interface Science. 2017;499:209 [Crossref]
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16- Wang W, Arias D, Deserno M, Ren X, Taylor R. Emerging applications at the interface of DNA nanotechnology and cellular membranes: Perspectives from biology, engineering, and physics. 2020;4(4) [Crossref]
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18- Yadav S, Singh P. Advancement and application of novel cell-penetrating peptide in cancer management. 3 Biotech. 2023;13(7) [Crossref]
19- Khan J, Alexander A, Alexander A, Saraf S, Saraf S. Exploring the role of polymeric conjugates toward anti-cancer drug delivery: Current trends and future projections. International Journal of Pharmaceutics. 2018;548(1):500 [Crossref]
20- Norouzi P, Mirmohammadi M, Houshdar Tehrani M. Anticancer peptides mechanisms, simple and complex. Chemico-Biological Interactions. 2022;368:110194 [Crossref]
21- Lichtenstein M, Zabit S, Hauser N, Farouz S, Melloul O, Hirbawi J, Lorberboum-Galski H. TAT for Enzyme/Protein Delivery to Restore or Destroy Cell Activity in Human Diseases. Life. 2021;11(9):924 [Crossref]
22- Wu Y, Yao X, Chen Y, Li Y, Tian W, Stoltz J, Magdalou J, Bensoussan D. Advance of DNA and CCPs-based nanocarriers in drug delivery systems. BME. 2017;28(s1):S255 [Crossref]
23- Gui L, Zhang X, Qiao Z, Wang H. Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery. ChemNanoMat. 2020;6(8):1138 [Crossref]
24- Martino M, Mouahid A, Sergent M, Desgrouas C, Badens C, Badens E. Supercritical millifluidic process for siRNA encapsulation in nanoliposomes for potential Progeria treatment (ex-vivo assays). Journal of Drug Delivery Science and Technology. 2023;87:104804 [Crossref]
25- Jafari S, Maleki-Dizaji N, Barar J, Barzegar-Jalali M, Rameshrad M, Adibkia K. Methylprednisolone acetate-loaded hydroxyapatite nanoparticles as a potential drug delivery system for treatment of rheumatoid arthritis: In vitro and in vivo evaluations. European Journal of Pharmaceutical Sciences. 2016;91:225 [Crossref]
26- Sajid M, Moazzam M, Stueber R, Park S, Cho Y, Malik N, Tiwari R. Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool. Peptides. 2021;141:170542 [Crossref]
27- Taha A, AL-Jawad S, AL-Barram L. Improvement of Cancer Therapy by TAT Peptide Conjugated Gold Nanoparticles. J Clust Sci. 2019;30(2):403 [Crossref]
28- Rusiecka I, Gągało I, Kocić I. Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs. Tissue Barriers. 2022;10(1) [Crossref]
29- Thapa R, Sullivan M. Gene delivery by peptide-assisted transport. Current Opinion in Biomedical Engineering. 2018;7:71 [Crossref]
30- Rostami B, Irani S, Bolhassani A, Cohan R. M918: A Novel Cell Penetrating Peptide for Effective Delivery of HIV-1 Nef and Hsp20-Nef Proteins into Eukaryotic Cell Lines. CHR. 2019;16(4):280 [Crossref]
31- Li M, Shi K, Tang X, Wei J, Cun X, Chen X, Yu Q, Zhang Z, He Q. pH-sensitive folic acid and dNP2 peptide dual-modified liposome for enhanced targeted chemotherapy of glioma. European Journal of Pharmaceutical Sciences. 2018;124:240 [Crossref]
32- Davoodi S, Bolhassani A, Namazi F. In vivo delivery of a multiepitope peptide and Nef protein using novel cell-penetrating peptides for development of HIV-1 vaccine candidate. Biotechnol Lett. 2021;43(3):547 [Crossref]
33- Asrorov A, Wang H, Zhang M, Wang Y, He Y, Sharipov M, Yili A, Huang Y. Cell penetrating peptides: Highlighting points in cancer therapy. Drug Development Research. 2023;84(6):1037 [Crossref]
34- Xing L, Zheng Y, Yu Y, Wu R, Liu X, Zhou R, Huang Y. Complying with the physiological functions of Golgi apparatus for secretory exocytosis facilitated oral absorption of protein drugs. J Mater Chem B. 2021;9(6):1707 [Crossref]
35- Klinsky O, Wetten P, Zanni-Ruiz E, Pavarotti M, Berberian M, Michaut M. The light chain of tetanus toxin bound to arginine-rich cell-penetrating peptide inhibits cortical reaction in mouse oocytes. Front Cell Dev Biol. 2023;11 [Crossref]
36- Tu K, Zhao L, Gu J, Yan P, Wang F, Cao Y. The function of activatable cell-penetrating peptides in human intrahepatic bile duct epithelial cells. J Bioenerg Biomembr. 2016;48(6):599 [Crossref]
37- Kardani K, Milani A, H. Shabani S, Bolhassani A. Cell penetrating peptides: the potent multi-cargo intracellular carriers. Expert Opinion on Drug Delivery. 2019;16(11):1227 [Crossref]
38- Bolhassani A, Jafarzade B, Mardani G. In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides. Peptides. 2017;87:50 [Crossref]
39- Kang R, Jang J, Huh E, Kang S, Ahn D, Kang J, Sailor M, Yeo S, Oh M, Kim D, Kim H. A brain tumor-homing tetra-peptide delivers a nano-therapeutic for more effective treatment of a mouse model of glioblastoma. Nanoscale Horiz. 2020;5(8):1213 [Crossref]
40- Streck S, Clulow A, Nielsen H, Rades T, Boyd B, McDowell A. The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering. Journal of Colloid and Interface Science. 2019;555:438 [Crossref]
41- Park S, Sajid M, Parang K, Tiwari R. Cyclic Cell-Penetrating Peptides as Efficient Intracellular Drug Delivery Tools. Mol Pharmaceutics. 2019;16(9):3727 [Crossref]
42- Kharga K, Jha S, Vishwakarma T, Kumar L. Current developments and prospects of the antibiotic delivery systems. Critical Reviews in Microbiology. 2024;:1 [Crossref]
43- Jafari S, Derakhshankhah H, Alaei L, Fattahi A, Varnamkhasti B, Saboury A. Mesoporous silica nanoparticles for therapeutic/diagnostic applications. Biomedicine & Pharmacotherapy. 2019;109:1100 [Crossref]
44- Moulahoum H, Ghorbanizamani F, Bayir E, Timur S, Zihnioglu F. A polyplex human saliva peptide histatin 5-grafted methoxy PEG-b-polycaprolactone polymersome for intelligent stimuli-oriented doxorubicin delivery. Journal of Drug Delivery Science and Technology. 2022;67:102958 [Crossref]
45- Abu-Dief A, Alsehli M, Al-Enizi A, Nafady A. Recent Advances in Mesoporous Silica Nanoparticles for Targeted Drug Delivery Applications. CDD. 2022;19(4):436 [Crossref]
46- Garay H, Espinosa L, Perera Y, Sánchez A, Diago D, Perea S, Besada V, Reyes O, González L. Characterization of low‐abundance species in the active pharmaceutical ingredient of CIGB‐300: A clinical‐grade anticancer synthetic peptide. Journal of Peptide Science. 2018;24(6) [Crossref]
47- Streck S, Bohr S, Birch D, Rades T, Hatzakis N, McDowell A, Mørck Nielsen H. Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking. ACS Appl Bio Mater. 2021;4(4):3155 [Crossref]
48- GUO Z, PENG H, KANG J, SUN D. Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications. 2016;4(5):528 [Crossref]
49- Jafari S, Maleki-Dizaji N, Barar J, Barzegar-Jalali M, Rameshrad M, Adibkia K. Physicochemical characterization and in vivo evaluation of triamcinolone acetonide-loaded hydroxyapatite nanocomposites for treatment of rheumatoid arthritis. Colloids and Surfaces B: Biointerfaces. 2016;140:223 [Crossref]
50- Nie C, Zou Y, Liao S, Gao Q, Li Q. Peptides as carriers of active ingredients: A review. Current Research in Food Science. 2023;7:100592 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
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