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Bioimpacts. 2015;5(4): 159-164. doi: 10.15171/bi.2015.31
PMID: 26929918        PMCID: PMC4769784

Editorial

Hydrogels for ocular drug delivery and tissue engineering

Marzieh Fathi 1, Jaleh Barar 1 ORCID, Ayuob Aghanejad 1, Yadollah Omidi 1 * ORCID

Cited by CrossRef: 55

1- Janga K, Tatke A, Dudhipala N, Balguri S, Ibrahim M, Maria D, Jablonski M, Majumdar S. Gellan Gum BasedSol-to-GelTransforming System of Natamycin Transfersomes Improves Topical Ocular Delivery. J Pharmacol Exp Ther. 2019;370(3):814 [Crossref]
2- Samiei M, Fathi M, Barar J, Fathi N, Amiryaghoubi N, Omidi Y. Bioactive hydrogel-based scaffolds for the regeneration of dental pulp tissue. Journal of Drug Delivery Science and Technology. 2021;64:102600 [Crossref]
3- Fathi M, Alami-Milani M, Geranmayeh M, Barar J, Erfan-Niya H, Omidi Y. Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer. International Journal of Biological Macromolecules. 2019;128:957 [Crossref]
4- Mostafa M, Al Fatease A, Alany R, Abdelkader H. Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases. Pharmaceutics. 2023;15(6):1746 [Crossref]
5- Mavlyanova R, Yang R, Tao T, Aquib M, Kesse S, Maviah M, Boakye‐Yiadom K, Farooq M, Wang B. Injectable hydrogels for targeted delivering of therapeutic molecules for tissue engineering and disease treatment. Polymers for Advanced Techs. 2020;31(2):192 [Crossref]
6- Lynch C, Kondiah P, Choonara Y, du Toit L, Ally N, Pillay V. Hydrogel Biomaterials for Application in Ocular Drug Delivery. Front Bioeng Biotechnol. 2020;8 [Crossref]
7- Babanejad N, Mfoafo K, Thumma A, Omidi Y, Omidian H. Advances in cryostructures and their applications in biomedical and pharmaceutical products. Polym Bull. 2023;80(12):12491 [Crossref]
8- Amiryaghoubi N, Noroozi Pesyan N, Fathi M, Omidi Y. Injectable thermosensitive hybrid hydrogel containing graphene oxide and chitosan as dental pulp stem cells scaffold for bone tissue engineering. International Journal of Biological Macromolecules. 2020;162:1338 [Crossref]
9- Yang S, Liu Z, Pan Y, Guan J, Yang P, Asel M. A Review of Research Progress on the Performance of Intelligent Polymer Gel. Molecules. 2023;28(10):4246 [Crossref]
10- Das B, Chattopadhyay D, Rana D. The gamut of perspectives, challenges, and recent trends for in situ hydrogels: a smart ophthalmic drug delivery vehicle. Biomater Sci. 2020;8(17):4665 [Crossref]
11- Al-Kinani A, Zidan G, Elsaid N, Seyfoddin A, Alani A, Alany R. Ophthalmic gels: Past, present and future. Advanced Drug Delivery Reviews. 2018;126:113 [Crossref]
12- Pakzad Y, Fathi M, Omidi Y, Mozafari M, Zamanian A. Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma. International Journal of Biological Macromolecules. 2020;159:117 [Crossref]
13- Younas F, Zaman M, Aman W, Farooq U, Raja M, Amjad M. Thiolated Polymeric Hydrogels for Biomedical Applications: A Review. CPD. 2023;29(40):3172 [Crossref]
14- Dhull A, Yu C, Wilmoth A, Chen M, Sharma A, Yiu S. Dendrimers in Corneal Drug Delivery: Recent Developments and Translational Opportunities. Pharmaceutics. 2023;15(6):1591 [Crossref]
15- Wang K, Han Z. Injectable hydrogels for ophthalmic applications. Journal of Controlled Release. 2017;268:212 [Crossref]
16- Raeisi A, Farjadian F. Commercial hydrogel product for drug delivery based on route of administration. Front Chem. 2024;12 [Crossref]
17- Liu H, Kijanka P, Urban M. Fluid surface tension evaluation using capillary wave measurement with optical coherence tomography. 2020;10(5) [Crossref]
18- Prasathkumar M, Dhrisya C, Lin F, Sadhasivam S. The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering. Adv Materials Technologies. 2023;8(15) [Crossref]
19- Torres-Luna C, Fan X, Domszy R, Hu N, Wang N, Yang A. Hydrogel-based ocular drug delivery systems for hydrophobic drugs. European Journal of Pharmaceutical Sciences. 2020;154:105503 [Crossref]
20- Barzegari A, Omidi Y, Ostadrahimi A, Gueguen V, Meddahi-Pellé A, Nouri M, Pavon-Djavid G. The role of Piezo proteins and cellular mechanosensing in tuning the fate of transplanted stem cells. Cell Tissue Res. 2020;381(1):1 [Crossref]
21- Alioghli Ziaei A, Erfan-Niya H, Fathi M, Amiryaghoubi N. In situ forming alginate/gelatin hybrid hydrogels containing doxorubicin loaded chitosan/AuNPs nanogels for the local therapy of breast cancer. International Journal of Biological Macromolecules. 2023;246:125640 [Crossref]
22- Mehta P, Sharma M, Devi M. Hydrogels: An overview of its classifications, properties, and applications. Journal of the Mechanical Behavior of Biomedical Materials. 2023;147:106145 [Crossref]
23- Tsung T, Tsai Y, Lee H, Chen Y, Lu D. Biodegradable Polymer-Based Drug-Delivery Systems for Ocular Diseases. IJMS. 2023;24(16):12976 [Crossref]
24- Pourjabbar B, Biazar E, Heidari Keshel S, Ahani-Nahayati M, Baradaran-Rafii A, Roozafzoon R, Alemzadeh-Ansari M. Bio-polymeric hydrogels for regeneration of corneal epithelial tissue*. International Journal of Polymeric Materials and Polymeric Biomaterials. 2022;71(11):797 [Crossref]
25- Poon S, Wong W, Bu Y, Lo A, Jhanji V, Chan Y, Shih K. A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface. 2020;46(6):329 [Crossref]
26- Rahmanian N, Eskandani M, Barar J, Omidi Y. Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines. Journal of Drug Targeting. 2017;25(3):202 [Crossref]
27- Regu V, Swain R, Subudhi B. Drug Delivery for Ocular Allergy: Current Formulation Design Strategies and Future Perspectives. CPD. 2023;29(33):2626 [Crossref]
28- Agban Y, Thakur S, Mugisho O, Rupenthal I. Depot formulations to sustain periocular drug delivery to the posterior eye segment. Drug Discovery Today. 2019;24(8):1458 [Crossref]
29- Mfoafo K, Kwon Y, Omidi Y, Omidian H. Contemporary applications of thermogelling PEO-PPO-PEO triblock copolymers. Journal of Drug Delivery Science and Technology. 2022;70:103182 [Crossref]
30- Anwary M, Kumar P, du Toit L, Choonara Y, Pillay V. Polymeric, injectable, intravitreal hydrogel devices for posterior segment applications and interventions. Artificial Cells, Nanomedicine, and Biotechnology. 2018;46(sup2):1074 [Crossref]
31- Ghanavi M, Khoshandam A, Aslzad S, Fathi M, Barzegari A, Dalir Abdolahinia E, Adibkia K, Barar J, Omidi Y. Injectable thermosensitive PEG-g-chitosan hydrogel for ocular delivery of vancomycin and prednisolone. Journal of Drug Delivery Science and Technology. 2023;83:104385 [Crossref]
32- Sharma A, Sharma P, Roy S. Elastin-inspired supramolecular hydrogels: a multifaceted extracellular matrix protein in biomedical engineering. Soft Matter. 2021;17(12):3266 [Crossref]
33- Osorno L, Maldonado D, Whitener R, Brandley A, Yiantsos A, Medina J, Byrne M. Amphiphilic PLGA‐PEG‐PLGA triblock copolymer nanogels varying in gelation temperature and modulus for the extended and controlled release of hyaluronic acid. J of Applied Polymer Sci. 2020;137(25) [Crossref]
34- Boddu S, Acharya D, Hala V, Jani H, Pande S, Patel C, Shahwan M, Jwala R, Ranch K. An Update on Strategies to Deliver Protein and Peptide Drugs to the Eye. ACS Omega. 2023;8(39):35470 [Crossref]
35- Nguyen D, Dowling J, Ryan R, McLoughlin P, Fitzhenry L. Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards. Contact Lens and Anterior Eye. 2021;44(6):101487 [Crossref]
36- Rana D, Salave S, Rawat G, Benival D. Recent Trends in Drug Delivery and Emerging Biomedical Applications of Gelatin for Ophthalmic Indications. Macromol Res. 2022;30(10):687 [Crossref]
37- Kumar N, Ghosh B, Kumar A, Koley R, Dhara S, Chattopadhyay S. Multilayered “SMART” hydrogel systems for on-site drug delivery applications. Journal of Drug Delivery Science and Technology. 2023;80:104111 [Crossref]
38- Ong N, Sim B, Chang J, Wong J, Loh X, Goh R. Recent advances in thermogels for the management of diabetic ocular complications. RSC Appl Polym. 2023;1(2):204 [Crossref]
39- Waite D, Wang Y, Jones D, Stitt A, Raj Singh T. Posterior drug delivery via periocular route: challenges and opportunities. Therapeutic Delivery. 2017;8(8):685 [Crossref]
40- Barar J, Aghanejad A, Fathi M, Omidi Y. Advanced drug delivery and targeting technologies for the ocular diseases. Bioimpacts. 2016;6(1):49 [Crossref]
41- Sahandi Zangabad P, Karimi M, Mehdizadeh F, Malekzad H, Ghasemi A, Bahrami S, Zare H, Moghoofei M, Hekmatmanesh A, Hamblin M. Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. Nanoscale. 2017;9(4):1356 [Crossref]
42- Pimple P, Sawant A, Nair S, Sawarkar S. Current Insights into Targeting Strategies for the Effective Therapy of Diseases of the Posterior Eye Segment . Crit Rev Ther Drug Carrier Syst. 2024;41(2):1 [Crossref]
43- Lin K, Wang A, Nguyen A, Iyer J, Tran S. Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives. Biomedicines. 2021;9(9):1203 [Crossref]
44- Safary A, Akbarzadeh Khiavi M, Mousavi R, Barar J, Rafi M. Enzyme replacement therapies: what is the best option?. Bioimpacts. 2018;8(3):153 [Crossref]
45- Ye J, Fu S, Zhou S, Li M, Li K, Sun W, Zhai Y. Advances in hydrogels based on dynamic covalent bonding and prospects for its biomedical application. European Polymer Journal. 2020;139:110024 [Crossref]
46- Cheng Y, Fung M, Chen Y, Chiu Y. Development of mucoadhesive methacrylic anhydride-modified hydroxypropyl methylcellulose hydrogels for topical ocular drug delivery. Journal of Drug Delivery Science and Technology. 2024;93:105450 [Crossref]
47- Rahimzadeh G, Saeedi M, Nokhodchi A, Moosazadeh M, Ghasemi M, Rostamkalaei S, Mortazavi P, Eghbali M, Pourbakhshian R, Rezai M, Nemati Hevelaee E. Evaluation of in-situ gel-forming eye drop containing bacteriophage against Pseudomonas aeruginosa keratoconjunctivitis in vivo . Bioimpacts. 2020;11(4):281 [Crossref]
48- Sattari M, Fathi M, Daei M, Erfan-Niya H, Barar J, Entezami A. Thermoresponsive graphene oxide – starch micro/nanohydrogel composite as biocompatible drug delivery system. Bioimpacts. 2017;7(3):167 [Crossref]
49- Bisht R, Nirmal S, Agrawal R, Jain G, Nirmal J. Injectablein-situgel depot system for targeted delivery of biologics to the retina. Journal of Drug Targeting. 2021;29(1):46 [Crossref]
50- Maharjan P, Cho K, Maharjan A, Shin M, Moon C, Min K. Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations. J Pharm Investig. 2019;49(2):215 [Crossref]
51- N R. Nano-formulations for Ophthalmic Treatments. Arch Pharm Pharm Sci. 2017;1(1):028 [Crossref]
52- Gorantla S, Waghule T, Rapalli V, Singh P, Dubey S, Saha R, Singhvi G. Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery. DDF. 2020;13(4):291 [Crossref]
53- Kim H, Woo S. Ocular Drug Delivery to the Retina: Current Innovations and Future Perspectives. Pharmaceutics. 2021;13(1):108 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge