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Bioimpacts. 2019;9(2): 105-113. doi: 10.15171/bi.2019.14
PMID: 31334042        PMCID: PMC6637214

Original Research

Determination of valproic acid and 3-heptanone in plasma using air-assisted liquid-liquid microextraction with the assistance of vortex: Application in the real samples

Behruz Feriduni 1, Mohammad Barzegar 2, Shahram Sadeghvand 3, Shadi Shiva 4, Maryam Khoubnasabjafari 5 ORCID, Abolghasem Jouyban 1,6 * ORCID

Cited by CrossRef: 11

1- Isaiah S, Loots D, van Furth A, Solomons R, van Elsland S, van der Kuip M, Mason S. Exploratory investigation of urinary alkanes and other volatile organic compounds in paediatric patients with tuberculous meningitis. Metabolomics. 2025;21(5) [Crossref]
2- Sommerfeld-Klatta K, Zielińska-Psuja B, Karaźniewcz-Łada M, Główka F. New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs). Molecules. 2020;25(21):5083 [Crossref]
3- Pourshamsi T, Amri F, Abniki M. A comprehensive review on application of the syringe in liquid- and solid-phase microextraction methods. J IRAN CHEM SOC. 2021;18(2):245 [Crossref]
4- de Oliveira J, dos Santos B, Sebben V, de Oliveira T, Arbo M. Fast determination of valproic acid in plasma samples from poisoning cases using HybridSPE-precipitation and LC-MS/MS. Legal Medicine. 2025;76:102662 [Crossref]
5- Fang Z, Zhang H, Guo J, Guo J. Overview of therapeutic drug monitoring and clinical practice. Talanta. 2024;266:124996 [Crossref]
6- Özen M, Ahmed H, Soylak M. Advances in sample preparation techniques combined with analytical methods for the determination of antiepileptic drugs (AEDs). TrAC Trends in Analytical Chemistry. 2025;191:118340 [Crossref]
7- Mohammadi P, Masrournia M, Es'haghi Z, Pordel M. Determination of four antiepileptic drugs with solvent assisted dispersive solid phase microextraction – Gas chromatography–mass spectrometry in human urine samples. Microchemical Journal. 2020;159:105542 [Crossref]
8- Azooz E, Al-Wani H, Gburi M, Al-Muhanna E. Recent modified air-assisted liquid–liquid microextraction applications for medicines and organic compounds in various samples: A review. 2022;20(1):525 [Crossref]
9- Naseri N, Kharrazi S, Abdi K, Alizadeh R. Fabrication of an SPME fiber based on ZnO@GA nanorods coated onto fused silica as a highly efficient absorbent for the analysis of cancer VOCs in water and urine. Analytica Chimica Acta. 2021;1183:338983 [Crossref]
10- Farajzadeh M, Mohebbi A, Pazhohan A, Nemati M, Afshar Mogaddam M. Air–assisted liquid–liquid microextraction; principles and applications with analytical instruments. TrAC Trends in Analytical Chemistry. 2020;122:115734 [Crossref]
11- Lipska K, Gumieniczek A, Pietraś R, Filip A. HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia. Molecules. 2021;26(10):2903 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

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