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Bioimpacts. 2019;9(2): 105-113. doi: 10.15171/bi.2019.14
PMID: 31334042        PMCID: PMC6637214

Original Research

Determination of valproic acid and 3-heptanone in plasma using air-assisted liquid-liquid microextraction with the assistance of vortex: Application in the real samples

Behruz Feriduni 1, Mohammad Barzegar 2, Shahram Sadeghvand 3, Shadi Shiva 4, Maryam Khoubnasabjafari 5 ORCID, Abolghasem Jouyban 1,6 * ORCID

Cited by CrossRef: 8

1- Sommerfeld-Klatta K, Zielińska-Psuja B, Karaźniewcz-Łada M, Główka F. New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs). Molecules. 2020;25(21):5083 [Crossref]
2- Pourshamsi T, Amri F, Abniki M. A comprehensive review on application of the syringe in liquid- and solid-phase microextraction methods. J IRAN CHEM SOC. 2021;18(2):245 [Crossref]
3- de Oliveira J, dos Santos B, Sebben V, de Oliveira T, Arbo M. Fast determination of valproic acid in plasma samples from poisoning cases using HybridSPE-precipitation and LC-MS/MS. Legal Medicine. 2025;76:102662 [Crossref]
4- Fang Z, Zhang H, Guo J, Guo J. Overview of therapeutic drug monitoring and clinical practice. Talanta. 2024;266:124996 [Crossref]
5- Özen M, Ahmed H, Soylak M. Advances in sample preparation techniques combined with analytical methods for the determination of antiepileptic drugs (AEDs). TrAC Trends in Analytical Chemistry. 2025;191:118340 [Crossref]
6- Mohammadi P, Masrournia M, Es'haghi Z, Pordel M. Determination of four antiepileptic drugs with solvent assisted dispersive solid phase microextraction – Gas chromatography–mass spectrometry in human urine samples. Microchemical Journal. 2020;159:105542 [Crossref]
7- Azooz E, Al-Wani H, Gburi M, Al-Muhanna E. Recent modified air-assisted liquid–liquid microextraction applications for medicines and organic compounds in various samples: A review. 2022;20(1):525 [Crossref]
8- Naseri N, Kharrazi S, Abdi K, Alizadeh R. Fabrication of an SPME fiber based on ZnO@GA nanorods coated onto fused silica as a highly efficient absorbent for the analysis of cancer VOCs in water and urine. Analytica Chimica Acta. 2021;1183:338983 [Crossref]
9- Farajzadeh M, Mohebbi A, Pazhohan A, Nemati M, Afshar Mogaddam M. Air–assisted liquid–liquid microextraction; principles and applications with analytical instruments. TrAC Trends in Analytical Chemistry. 2020;122:115734 [Crossref]
10- Lipska K, Gumieniczek A, Pietraś R, Filip A. HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia. Molecules. 2021;26(10):2903 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate (2024): 20% 
Publication fee: Free of charge

Indexing/Abstracting Info
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