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Bioimpacts. 2019;9(2): 79-88. doi: 10.15171/bi.2019.11
PMID: 31334039        PMCID: PMC6637216

Original Research

Therapeutic potency of substituted chromones as Alzheimer’s drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation

Prayasee Baruah 1, Mostofa Ataur Rohman 1, Semen O. Yesylevskyy 2, Sivaprasad Mitra 1 * ORCID

Cited by CrossRef: 9

1- Baruah P, Paul D, Doshi J, Mitra S. Elevated Fibrinogen Level Reduces Therapeutic Efficiency of AD Drugs: Biophysical Insights into the Interaction of FDA-Approved Cholinesterase Inhibitors with Human Fibrinogen. J Phys Chem B. 2022;126(1):30 [Crossref]
2- Benny A, Radhakrishnan E. Advances in the site-selective C-5, C-3 and C-2 functionalization of chromones via sp2 C–H activation. RSC Adv. 2022;12(6):3343 [Crossref]
3- Zhao Q, Cheng J, Bian X, Wang C, Xu Y, Ding H, Ren H, Zhang Y, Xu M, Shan C, Qian D, Duan J, Yan H, Huang X. Pharmacokinetics-Derived Absorbed Components Responsible for Guizhi-Fuling Capsule Target PI3K/Akt-Erk to Exert Anti-Dysmenorrhea Effect. SSRN Journal. 2022; [Crossref]
4- Baruah P, Yesylevskyy S, Aguan K, Mitra S. Modulation of enzyme activity at nano-bio interface: A case study with acetylcholinesterase and citrate synthase adsorbed on colloidal metal nanoparticles. Journal of Molecular Liquids. 2021;325:115201 [Crossref]
5- Xia H, Sun Q, Gan N, Ai P, Li H, Li Y. Unveiling the binding details and esterase-like activity effect of methyl yellow on human serum albumin: spectroscopic and simulation study. RSC Adv. 2023;13(12):8281 [Crossref]
6- Rohman M, Baruah P, Bhattacharjee D, Myrboh B, Mitra S. Fluorescence solvatochromism and modulated anticholinergic activity of novel coumarin compounds sequestered in human serum albumin nanocavities. New J Chem. 2019;43(47):18713 [Crossref]
7- Zhao Q, Cheng J, Bian X, Wang C, Xu Y, Ding H, Ren H, Zhang Y, Xu M, Shan C, Yan H, Duan J, Qian D, Huang X. Pharmacokinetics-derived absorbed components responsible for Guizhi-Fuling capsule target PI3K/Akt-Erk to exert an anti-dysmenorrhea effect. Journal of Ethnopharmacology. 2022;297:115525 [Crossref]
8- Benny A, Arikkatt S, Vazhappilly C, Kannadasan S, Thomas R, Leelabaiamma M, Radhakrishnan E, Shanmugam P. Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity. MRMC. 2022;22(7):1030 [Crossref]
9- Ahmed E, Serry A, Aly H, Fouad G, Abdelhafez O. Design, synthesis and molecular docking studies of tailored coumarin and chromone derivatives for use as anti-Alzheimer agents. Journal of Molecular Structure. 2025;1323:140732 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge