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Bioimpacts. 2019;9(2): 79-88. doi: 10.15171/bi.2019.11
PMID: 31334039        PMCID: PMC6637216

Original Research

Therapeutic potency of substituted chromones as Alzheimer’s drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation

Prayasee Baruah 1, Mostofa Ataur Rohman 1, Semen O. Yesylevskyy 2, Sivaprasad Mitra 1 * ORCID

Cited by CrossRef: 9

1- Baruah P, Paul D, Doshi J, Mitra S. Elevated Fibrinogen Level Reduces Therapeutic Efficiency of AD Drugs: Biophysical Insights into the Interaction of FDA-Approved Cholinesterase Inhibitors with Human Fibrinogen. J Phys Chem B. 2022;126(1):30 [Crossref]
2- Benny A, Radhakrishnan E. Advances in the site-selective C-5, C-3 and C-2 functionalization of chromones via sp2 C–H activation. RSC Adv. 2022;12(6):3343 [Crossref]
3- Zhao Q, Cheng J, Bian X, Wang C, Xu Y, Ding H, Ren H, Zhang Y, Xu M, Shan C, Qian D, Duan J, Yan H, Huang X. Pharmacokinetics-Derived Absorbed Components Responsible for Guizhi-Fuling Capsule Target PI3K/Akt-Erk to Exert Anti-Dysmenorrhea Effect. SSRN Journal. 2022; [Crossref]
4- Shah A, Dar M, Adnan M, Varma T, Agarwal D, Garg P, Mir R, Meena R, Masoodi M. Integration of phytochemical profiling and computational approaches to evaluate the neuroprotective potential of Nardostachys jatamansi in Alzheimer's disease. Biotechnology Reports. 2025;45:e00881 [Crossref]
5- Baruah P, Yesylevskyy S, Aguan K, Mitra S. Modulation of enzyme activity at nano-bio interface: A case study with acetylcholinesterase and citrate synthase adsorbed on colloidal metal nanoparticles. Journal of Molecular Liquids. 2021;325:115201 [Crossref]
6- Xia H, Sun Q, Gan N, Ai P, Li H, Li Y. Unveiling the binding details and esterase-like activity effect of methyl yellow on human serum albumin: spectroscopic and simulation study. RSC Adv. 2023;13(12):8281 [Crossref]
7- Rohman M, Baruah P, Bhattacharjee D, Myrboh B, Mitra S. Fluorescence solvatochromism and modulated anticholinergic activity of novel coumarin compounds sequestered in human serum albumin nanocavities. New J Chem. 2019;43(47):18713 [Crossref]
8- Zhao Q, Cheng J, Bian X, Wang C, Xu Y, Ding H, Ren H, Zhang Y, Xu M, Shan C, Yan H, Duan J, Qian D, Huang X. Pharmacokinetics-derived absorbed components responsible for Guizhi-Fuling capsule target PI3K/Akt-Erk to exert an anti-dysmenorrhea effect. Journal of Ethnopharmacology. 2022;297:115525 [Crossref]
9- Benny A, Arikkatt S, Vazhappilly C, Kannadasan S, Thomas R, Leelabaiamma M, Radhakrishnan E, Shanmugam P. Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity. MRMC. 2022;22(7):1030 [Crossref]
10- Ahmed E, Serry A, Aly H, Fouad G, Abdelhafez O. Design, synthesis and molecular docking studies of tailored coumarin and chromone derivatives for use as anti-Alzheimer agents. Journal of Molecular Structure. 2025;1323:140732 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge