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Bioimpacts. 2023;13(1): 51-61. doi: 10.34172/bi.2022.23698
PMID: 36816998        PMCID: PMC9923812

Original Research

Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy

Sevda Jafari 1,2 ORCID, Saba Heydarian 1,2, Raymond Lai 3, Elnaz Mehdizadeh Aghdam 2, Ommoleila Molavi 1,2 * ORCID

Cited by CrossRef: 3

1- Malla R, Kumari S, Ganji S, Srilatha M, Nellipudi H, Nagaraju G. Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2024;1879(5):189154 [Crossref]
2- Khan M, Rehman M, Arshad M, Karthikeyan S, Alokail M, Kheraif A, Alamri A, AlAjmi M. Exploring conformational changes in β-lactoglobulin (β-LG) induced by silibinin: A comprehensive analysis of polyphenol-protein interaction. Journal of Molecular Structure. 2025;1322:140260 [Crossref]
3- Moon Y, Cho H, Kim K. Nano-Delivery of Immunogenic Cell Death Inducers and Immune Checkpoint Blockade Agents: Single-Nanostructure Strategies for Enhancing Immunotherapy. Pharmaceutics. 2024;16(6):795 [Crossref]
4- Montazersaheb S, Farahzadi R, Fathi E, Alizadeh M, Abdolalizadeh Amir S, Khodaei Ardakan A, Jafari S. Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways. Heliyon. 2024;10(5):e26959 [Crossref]
5- Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. 2023;11(6):1709 [Crossref]
6- Zhang L, Zhang D, Shi J, Huang M, Yu J, Chen X, Wei X, Zou L, Lu J. Immunogenic cell death inducers for cancer therapy: An emerging focus on natural products. Phytomedicine. 2024;132:155828 [Crossref]
7- Jafari S, Ardakan A, Aghdam E, Mesbahi A, Montazersaheb S, Molavi O. Induction of immunogenic cell death and enhancement of the radiation-induced immunogenicity by chrysin in melanoma cancer cells. Sci Rep. 2024;14(1) [Crossref]
8- Amiri M, Molavi O, Sabetkam S, Jafari S, Montazersaheb S. Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds. Cancer Cell Int. 2023;23(1) [Crossref]
9- Oliyapour Y, Dabiri S, Molavi O, Hejazi M, Davaran S, Jafari S, Montazersaheb S. Chrysin and chrysin-loaded nanocarriers induced immunogenic cell death on B16 melanoma cells. Med Oncol. 2023;40(10) [Crossref]
10- Wang R, Huang X, Chen X, Zhang Y. Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer. ACS Biomater Sci Eng. 2024;10(6):3568 [Crossref]
11- Yang L, Han T, Liu R, Shi S, Luan S, Meng S. Plant-derived natural compounds: A new frontier in inducing immunogenic cell death for cancer treatment. Biomedicine & Pharmacotherapy. 2024;177:117099 [Crossref]
12- Zhang G, Wang L, Zhao L, Yang F, Lu C, Yan J, Zhang S, Wang H, Li Y. Silibinin Induces Both Apoptosis and Necroptosis with Potential Anti-tumor Efficacy in Lung Cancer. ACAMC. 2024;24(18):1327 [Crossref]
13- Montazersaheb S, Eftekhari A, Shafaroodi A, Tavakoli S, Jafari S, Baran A, Baran M, Jafari S, Ahmadian E. Green-synthesized silver nanoparticles from peel extract of pumpkin as a potent radiosensitizer against triple-negative breast cancer (TNBC). Cancer Nano. 2024;15(1) [Crossref]
14- Demir M, Altinoz E, Koca O, Elbe H, Onal M, Bicer Y, Karayakali M. Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats. Tissue and Cell. 2023;84:102182 [Crossref]

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
Publication fee: Free of charge