Aditya Singh
1* 
, Shubhrat Maheshwari
2, Anvi Patel
3, Bhupendra G. Prajapati
4,5* , Ankush Mehta
6, Kiran Dudhat
71 Department of Pharmaceutics, Parul Institute of Pharmacy & Research, Parul University, Waghodia, Vadodara – 391760, Gujarat, India
2 Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, 211007, India
3 Faculty of Pharmacy, Ganpat University, Mehsana, 304012, Gujarat, India
4 Department of Pharmaceutics, Parul Institute of Pharmacy, Faculty of Pharmacy, Parul University, Waghodia, Vadodara, 391760, Gujarat, India
5 Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India
6 School of Engineering and Technology, K. R. Mangalam University, Gurugram, 122103, Haryana, India
7 School of Pharmacy, RK University, Kasturbadham, Rajkot, Gujarat, 360020, India
Abstract
Nanoparticles have emerged as a promising strategy in dental implantology to enhance implant integration and therapeutic functionality. Nanostructured surface modifications enable precise control over implant topography and chemistry, leading to increased surface area, improved protein adsorption, and enhanced cellular adhesion, key factors for successful osseointegration. Various nanoparticle systems, including titanium dioxide (TiO₂), hydroxyapatite, and bioactive glass, have been extensively explored for surface modification and functional enhancement of dental implants. In addition to structural benefits, nanoparticles facilitate localized and controlled drug delivery, reducing infection risk, minimizing systemic side effects, and accelerating tissue healing. Despite these advancements, challenges such as long-term stability, biocompatibility, optimization of drug release kinetics, and potential toxicity remain critical barriers to clinical translation. Therefore, further research is required to ensure safe and effective application of nanoparticle-based dental implants in clinical practice.