1. CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis

Zhengmin Liang , Miaoxuan Li, Jiamin Ni, Tariq Hussain, Jiao Yao, Yinjuan Song, Yiduo Liu, Haoran Wang, Xiangmei Zhou*

BioImpacts. 2022;12(5): 395-404. doi: 10.34172/bi.2022.23645

PMCID: PMC9596879 PMID: 36381632 Scopus ID: 85140257880

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CFP10-NPs significantly enhanced the secretion of TNF-α and IL-1β in J774A.1 macrophages. Mucosal immunization with CFP10-NPs significantly increased the levels of TNF-α, IL-1β, IgA and CFP10-specific IFN-γ, and decreased bacterial load in lungs and spleen of M. bovis-infected mice.

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