1. miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI

Mohammad Hasan Soheilifar , Majid Pornour , Massoud Saidijam, Rezvan Najafi, Farid Azizi Jalilian, Hoda Keshmiri Neghab, Razieh Amini*

BioImpacts. 2022;12(4): 349-358. doi: 10.34172/bi.2021.23571

PMCID: PMC9376166 PMID: 35975203 Scopus ID: 85130482955

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MiR-1290 through suppression of THBS1 and DKK3 could activate PI3K/AKT pathway. Moreover, DKK3 and SCAI inhibition might induce wnt/β-catenin signaling pathway. Hence, regulatory interplay between miR-1290 and its targets may promote oncogenesis and angiogenesis in CRC through PI3K/AKT and Wnt/ β-catenin signaling pathways activation.

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