1. Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin

Ashkan Hassankhani Rad , Farshid Asiaee , Sevda Jafari , Ali Shayanfar , Afsaneh Lavasanifar , Ommoleila Molavi*

Bioimpacts. 2020;10(2): 87-95. doi: 10.34172/bi.2020.11

PMCID: PMC7186544 PMID: 32363152 Scopus ID: 85086435091

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Silibinin is a natural and non-toxic compound which has some beneficial effects in cancer treatment. But, poor water solubility of silibinin limits its clinical application. Here, encapsulation of silibinin in the PEG-PCL based micelles increased water solubility of silibinin and enhanced its functional delivery to melanoma cancer cells.

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