1. Enhanced control of bioactivity of tissue plasminogen activator (tPA) through domain-directed enzymatic oxidation of terminal galactose

Wael A. Mahdi , Mohammad S. Absar, Suna Choi, Victor C. Yang, Young M. Kwon*

BioImpacts. 2022;12(6): 479-486. doi: 10.34172/bi.2022.23477

PMCID: PMC9809136 PMID: 36644546 Scopus ID: 85143309781

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The tPA was successfully modified via enzymatic oxidation by GO, resulting in enhanced control of its activity in the prodrug construct. This approach can be applied to other therapeutic glycoproteins.

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