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Original Research
Mohammad A. Rafi ORCID, Paola Luzi, David A. Wenger* ORCID
Bioimpacts. 2020;10(2): 105-115. doi: 10.34172/bi.2020.13
PMCID: PMC7186542     PMID: 32363154     Scopus ID: 85090729388    
Krabbe disease (KD) is an autosomal recessive lysosomal disorder that imposes defective myelination in the peripheral and central nervous systems. Twitcher combining bone marrow transplantation with AAVrh10-mGALC can have a great extension of life in the murine model of KD.
Original Research
Mohammad A Rafi* ORCID, Paola Luzi, David A Wenger ORCID
BioImpacts. 2021;11(2): 135-146. doi: 10.34172/bi.2021.21
PMCID: PMC8022232     PMID: 33842284     Scopus ID: 85106877684    
Our results demonstrate that, it may be possible to treat human KD patients with high dose AAVrh10 without blood stem cell transplantation which would eliminate the side effects of HSCT.


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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