1. Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages

Reddy Amala, Sundaresan Sujatha*

BioImpacts. 2021;11(1): 15-22. doi: 10.34172/bi.2021.03

PMCID: PMC7803918 PMID: 33469504 Scopus ID: 85099218046

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LPS stimulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by binding toTLR-4. iNOS produced enormous nitric oxide (NO) that stimulated COX-2 activity and prostaglandin E2 which further induced the production of pro-inflammatory cytokines leading to inflammation. ALK-F of A. vasica could attenuate iNOS and COX-2 gene expression reducing NO production.

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2. Artesunate reduces sepsis-mediated acute lung injury in a SIRT1-dependent manner

Zhaohui Liu* , Yanli Meng, Yu Miao, Lili Yu, Qiannan Yu

Bioimpacts. 2023;13(3): 219-228. doi: 10.34172/bi.2023.23585

PMCID: PMC10329753 PMID: 37431481 Scopus ID: 85171351230

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Our findings could suggest the use of AS for treating lung disorders through a mechanism involving SIRT1 expression.

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