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Original Research

1. Enhancing radiosensitivity of TE1, TE8, and TE 11 esophageal squamous carcinoma cell lines by Hdm2-siRNA targeted gene therapy in vitro
Jalil Pirayesh Islamian*, Mohsen Mohammadi, Behzad Baradaran, Alireza Farajollahi, Seyed Mahmoud Reza Aghamiri, Mohammad Asghari Jafarabadi, Haadi Karami, Amir Monfaredan, Dariuosh Shanehbandi
Bioimpacts. 2016;6(2): 93-98. doi: 10.15171/bi.2016.13
PMCID: PMC4981254     PMID: 27525226     Scopus ID: 84983516628    
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Original Research

2. Impact of RAS/RAF mutations on clinical and prognostic outcomes in metastatic colorectal cancer

Roya Dolatkhah ORCID, Saeed Dastgiri ORCID, Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi* ORCID
BioImpacts. 2021;11(1): 5-14. doi: 10.34172/bi.2021.02
PMCID: PMC7803924     PMID: 33469503     Scopus ID: 85099264583    
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It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.
Original Research

3. miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI

Mohammad Hasan Soheilifar ORCID, Majid Pornour ORCID, Massoud Saidijam, Rezvan Najafi, Farid Azizi Jalilian, Hoda Keshmiri Neghab, Razieh Amini* ORCID
BioImpacts. 2022;12(4): 349-358. doi: 10.34172/bi.2021.23571
PMCID: PMC9376166     PMID: 35975203     Scopus ID: 85130482955    
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MiR-1290 through suppression of THBS1 and DKK3 could activate PI3K/AKT pathway. Moreover, DKK3 and SCAI inhibition might induce wnt/β-catenin signaling pathway. Hence, regulatory interplay between miR-1290 and its targets may promote oncogenesis and angiogenesis in CRC through PI3K/AKT and Wnt/ β-catenin signaling pathways activation.

As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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