1. Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers

Fatemeh Khonsari , Mostafa Heydari , Rassoul Dinarvand , Mohammad Sharifzadeh , Fatemeh Atyabi*

Bioimpacts. 2022;12(1): 21-32. doi: 10.34172/bi.2021.23389

PMCID: PMC8783081 PMID: 35087713 Scopus ID: 85127207881

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Nanostructured-Lipid-Carriers (NLCs) for brain delivery of rapamycin were designed by modification of optimized cationic-NLCs (C-NLC) with different approaches. The targeted transferrin decorated NLCs(Tf-NLCs) in comparison to untargeted bare-NLCs (B-NLCs) showed higher cellular uptake and appropriate targeted accumulation in the brain.

Original Article

2. Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells

Yuri Yu. Shchegolev , Danila V. Sorokin, Alexander M. Scherbakov* , Olga E. Andreeva , Diana I. Salnikova , Ekaterina I. Mikhaevich , Margarita V. Gudkova , Mikhail A. Krasil’nikov

Bioimpacts. 2023;13(4): 313-321. doi: 10.34172/bi.2023.27490

PMCID: PMC10460766 PMID: 37645026 Scopus ID: 85168127787

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Prolonged cell treatment with mTOR inhibitor rapamycin leads to the development of resistance. Exosomes of resistant cells induce the resistance to rapamycin in the parent MCF-7cells. Exosome-induced resistance reproduces the changes revealed in the rapamycin-resistant cells, including the activation of ERK/AP-1.

Original Article

3. Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)

Fateme Arjmand , Samaneh Shojaei, Mitra Khalili, Hossein Dinmohammadi, Behzad Poopak, Samira Mohammadi-Yeganeh* , Yousef Mortazavi*

Bioimpacts. 2024;14(4): 28870. doi: 10.34172/bi.2023.28870

PMCID: PMC11298021 PMID: 39104620

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As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences.
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