1. Melatonin increases 5-flurouracil-mediated apoptosis of colorectal cancer cells through enhancing oxidative stress and downregulating survivin and XIAP

Ainaz Mihanfar, Bahman Yousefi, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Maryam Majidinia*

BioImpacts. 2021;11(4): 253-261. doi: 10.34172/bi.2021.36

PMCID: PMC8494259 PMID: 34631487 Scopus ID: 85113774001

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Treatment of SW-480 cancer cell lines with a combination of 5-FU and melatonin results in the increment in the sensitivity of cancer cells to 5-FU through downregulation of XIAP and survivin, as well as modulation of oxidative stress.

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