1. In vitro study of the anticancer activity of various doxorubicin-containing dispersions

Tatiana Matvienko, Viktoriya Sokolova, Svitlana Prylutska, Yuliia Harahuts, Nataliya Kutsevol, Viktor Kostjukov, Maxim Evstigneev* , Yuriy Prylutskyy*, Matthias Epple, Uwe Ritter

Bioimpacts. 2019;9(1): 57-63. doi: 10.15171/bi.2019.07

PMCID: PMC6378100 PMID: 30788260 Scopus ID: 85060451771

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It was found that the Dextran-PNIPAM+Dox nanofluid in contrast to Dox alone showed higher toxicity towards HeLa cells, whereas the SWCNT+Dox and GO+Dox nanofluids protected cells from Dox.

Original Research

2. Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin

Ashkan Hassankhani Rad , Farshid Asiaee , Sevda Jafari , Ali Shayanfar , Afsaneh Lavasanifar , Ommoleila Molavi*

Bioimpacts. 2020;10(2): 87-95. doi: 10.34172/bi.2020.11

PMCID: PMC7186544 PMID: 32363152 Scopus ID: 85086435091

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Silibinin is a natural and non-toxic compound which has some beneficial effects in cancer treatment. But, poor water solubility of silibinin limits its clinical application. Here, encapsulation of silibinin in the PEG-PCL based micelles increased water solubility of silibinin and enhanced its functional delivery to melanoma cancer cells.

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As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences.
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