Zeinab Karimi  , Sahar Janfeshan, Elias Kargar Abarghouei, Seyedeh-Sara Hashemi*
Renal functional and structural disturbance induced by renal bilateral ischemia/reperfusion. However, administration of bone marrow stem cell (1.5×106 cells, i.p., per rat) improved renal function and appearance. Protective effect of BMSCs related to modulation of mRNA expression of TLR2 and TLR4.
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Mohammad A. Rafi , Paola Luzi, David A. Wenger*
Krabbe disease (KD) is an autosomal recessive lysosomal disorder that imposes defective myelination in the peripheral and central nervous systems. Twitcher combining bone marrow transplantation with AAVrh10-mGALC can have a great extension of life in the murine model of KD.
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Sepideh Sheshpari , Mahnaz Shahnazi, Shahin Ahmadian, Mohammad Nouri, Mehran Mesgari Abbasi, Rahim Beheshti, Reza Rahbarghazi, Ali Honaramooz, Mahdi Mahdipour*
The administration of c-Kit+ cells can modulate angiogenesis and pathological changes, leading to the rejuvenation of ovarian function of a rat model of premature menopause.
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Mohammad A Rafi* , Paola Luzi, David A Wenger
Our results demonstrate that, it may be possible to treat human KD patients with high dose AAVrh10 without blood stem cell transplantation which would eliminate the side effects of HSCT.
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Mohammad A. Rafi*
Cutting viral dose in half or using BM cells from heterozygote mice in a combination of BMT and gene therapy treatments result in a similar reduction in lifespan of the treated mice.
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Nahideh Nazdikbin Yamchi , Farhad Amjadi, Rahim Beheshti, Mehdi Hassanpour, Reza Shirazi, Amin Tamadon , Reza Rahbarghazi , Mahdi Mahdipour*
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