2025, Vol 15

Editor-in-Chief

Prof. Khosro Adibkia

Editorial

1. Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates

Mostafa Akbarzadeh Khiavi , Azam Safary , Mohammad Hossein Somi*

Bioimpacts. 2019;9(3): 123-127. doi: 10.15171/bi.2019.16

PMCID: PMC6726747 PMID: 31508327 Scopus ID: 85071152476

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Colorectal cancer (CRC) as a malignancy shows high mortality rate worldwide because of metastasis and drug resistance. Targeted multimodal nanosystems (NSs) can be developed and used against CRC with much better clinical outcomes.

Original Research

2. PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells

Mostafa Akbarzadeh Khiavi , Azam Safary , Jaleh Barar , Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi* , Yadollah Omidi*

Bioimpacts. 2020;10(1): 27-36. doi: 10.15171/bi.2020.04

PMCID: PMC6977588 PMID: 31988854 Scopus ID: 85078959970

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The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.

Original Research

3. Impact of RAS/RAF mutations on clinical and prognostic outcomes in metastatic colorectal cancer

Roya Dolatkhah , Saeed Dastgiri , Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi*

BioImpacts. 2021;11(1): 5-14. doi: 10.34172/bi.2021.02

PMCID: PMC7803924 PMID: 33469503 Scopus ID: 85099264583

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It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.

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As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences.
Acceptance rate (2024): 20%
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