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Editorial
Morteza Mahmoudi* ORCID, Sherry Moss
Bioimpacts. 2020;10(2): 63-64. doi: 10.34172/bi.2020.08
PMCID: PMC7186547     PMID: 32363149     Scopus ID: 85088405956    
Dr. Morteza Mahmoudi is an Assistant Professor of Radiology and Precision Health Program at Michigan State University (MSU). His specific research interest is in nanomedicine and regenerative medicine for the development of new nano-based platforms for prevention/treatment of life-threatening conditions.

Original Research
Hadi Maleki-Kakelar ORCID, Jaber Dehghani, Abolfazl Barzegari, Jaleh Barar ORCID, Masoud Shirmohamadi, Javid Sadeghi, Yadollah Omidi* ORCID
Bioimpacts. 2020;10(2): 65-72. doi: 10.34172/bi.2020.09
PMCID: PMC7186545     PMID: 32363150     Scopus ID: 85088607061    
Based on in vitro experiments, the anti-cancer effect of the locally isolated L. plantarum was validated through some signaling pathways, including PTEN, Bax, TLR4, and AKT genes.

Original Research
Maryam Sadat Khoramgah ORCID, Javad Ranjbari, Hojjat-Allah Abbaszadeh, Fatemeh Sadat Tabatabaei Mirakabad, Shadie Hatami, Simzar Hosseinzadeh* ORCID, Hossein Ghanbarian* ORCID
Bioimpacts. 2020;10(2): 73-85. doi: 10.34172/bi.2020.10
PMCID: PMC7186540     PMID: 32363151     Scopus ID: 85083393226    
Nanofibrous scaffold made from PTFE, PVA and GO nanoparticles could be a candidate for bone tissue engineering due to appropriate activity for commitment and differentiation of hADSCs to bone tissue cells.

Original Research
Ashkan Hassankhani Rad ORCID, Farshid Asiaee ORCID, Sevda Jafari ORCID, Ali Shayanfar ORCID, Afsaneh Lavasanifar ORCID, Ommoleila Molavi* ORCID
Bioimpacts. 2020;10(2): 87-95. doi: 10.34172/bi.2020.11
PMCID: PMC7186544     PMID: 32363152     Scopus ID: 85086435091    
Silibinin is a natural and non-toxic compound which has some beneficial effects in cancer treatment. But, poor water solubility of silibinin limits its clinical application. Here, encapsulation of silibinin in the PEG-PCL based micelles increased water solubility of silibinin and enhanced its functional delivery to melanoma cancer cells.

Original Research
Reza Ferdousi ORCID, Ali Akbar Jamali ORCID, Reza Safdari* ORCID
Bioimpacts. 2020;10(2): 97-104. doi: 10.34172/bi.2020.12
PMCID: PMC7186546     PMID: 32363153     Scopus ID: 85090696578    
The Market Basket Analysis (MBA) was used to identify bio-elements involved in the occurrence of drug-drug interactions (DDIs), which resulted in the identification of over 200,000 potential DDIs. The MBA can be used in the prediction of nonlinear biological issues.

Original Research
Mohammad A. Rafi ORCID, Paola Luzi, David A. Wenger* ORCID
Bioimpacts. 2020;10(2): 105-115. doi: 10.34172/bi.2020.13
PMCID: PMC7186542     PMID: 32363154     Scopus ID: 85090729388    
Krabbe disease (KD) is an autosomal recessive lysosomal disorder that imposes defective myelination in the peripheral and central nervous systems. Twitcher combining bone marrow transplantation with AAVrh10-mGALC can have a great extension of life in the murine model of KD.

Original Research
Fatemeh Rahimi-Sherbaf ORCID, Samad Nadri ORCID, Ali Rahmani, Atousa Dabiri Oskoei* ORCID
Bioimpacts. 2020;10(2): 117-122. doi: 10.34172/bi.2020.14
PMCID: PMC7186541     PMID: 32363155     Scopus ID: 85090604351    
Stem cells has shown different behavior and differentiation pattern due to its microenvironment. The neural differentiation of PMSCs were affected by its substrate. 3D hybrid nanoscaffold has different impact on neural differentiation of PMSCs

Original Research
Bhavya Somalapura Gangadharappa, Sharath Rajashekarappa* ORCID, Gajanan Sathe
Bioimpacts. 2020;10(2): 123-135. doi: 10.34172/bi.2020.15
PMCID: PMC7186543     PMID: 32363156     Scopus ID: 85090708773    
Proteomic analysis of S. marcescens (ATCC 13880) was performed using mass spectrometry-based proteomics approach and identified 2541 unique protein groups. The identified proteins were analysed for their protein-protein interactions, Gene Ontology, and pathway analysis.